A5029919323- Environmental Toxicology and Ecotoxicology
- Pesticide Exposure and Toxicity
- Zebrafish Biomedical Research Applications
- Pesticide and Herbicide Environmental Studies
- Cholinesterase and Neurodegenerative Diseases
- Animal testing and alternatives
- Toxic Organic Pollutants Impact
- Insect and Pesticide Research
- Neurotransmitter Receptor Influence on Behavior
- Fish Ecology and Management Studies
- ATP Synthase and ATPases Research
- Parasite Biology and Host Interactions
- Antioxidant Activity and Oxidative Stress
- Antimicrobial agents and applications
- Photochromic and Fluorescence Chemistry
- Effects and risks of endocrine disrupting chemicals
- Aluminum toxicity and tolerance in plants and animals
- Climate Change and Health Impacts
- Hydrocarbon exploration and reservoir analysis
- DNA Repair Mechanisms
- Metal Extraction and Bioleaching
- Heavy Metal Exposure and Toxicity
- Reproductive Physiology in Livestock
- Physiological and biochemical adaptations
- Plant Surface Properties and Treatments
Environmental Protection Agency
2008-2024
Research Triangle Park Foundation
1999-2024
Royal London Hospital
1944
Medical Research Council
1944
Organophosphate flame retardants (OPFRs) are common replacements for the phased-out polybrominated diphenyl ethers (PBDEs) and have been detected at high concentrations in environmental samples. OPFRs structurally similar to organophosphate pesticides may adversely affect developing nervous system. This study evaluated overt toxicity, uptake, neurobehavioral effects of tris (1,3-dichloro-2-propyl) phosphate (TDCPP), (2-chloroethyl) (TCEP), (1-chloro-2-propyl) (TCPP), (2,3-dibromopropyl)...
This study aimed to model long-term subtoxic human exposure an organophosphorus pesticide, chlorpyrifos, and examine the influence of that on response intermittent high-dose acute challenges. Adult Long-Evans male rats were maintained at 350 g body weight by limited access a chlorpyrifos-containing diet produce intake 0, 1, or 5 mg/kg/day chlorpyrifos. During year-long exposure, half in each dose group received bi-monthly challenges (spikes) other vehicle. Rats periodically tested using...
Journal Article Reproductive Steroids in the Bovine. I. Relationships during Late Gestation Get access D. L. Hunter, Hunter 4Purdue University, Lafayette, Indiana Search for other works by this author on: Oxford Academic PubMed Google Scholar R. E. Erb, Erb Randel, Randel H. A. Garverick, Garverick C. J. Callahan, Callahan B. Harrington of Animal Science, Volume 30, Issue 1, January 1970, Pages 47–59, https://doi.org/10.2527/jas1970.30147x Published: 01 1970
This communication records the toxic effects caused by tri-ortho-cresyl phosphate in three men employed its manufacture. Tricresyl is used recovery of phenol residues from gas plant effluents and also as a plasticizer plastics industry. A substance to render plastic material more pliable, alteration amount added, such characteristics flexibility, hardness, water resistance inflammability can be varied between wide limits. In this industry it being increasing quantities, for example, much 50...
Cognitive and motor impairment often follow acute poisoning with an organophosphorous (OP) pesticide. However, the persistence of these effects conditions necessary for their appearance are not clear: two specific concerns whether symptomatic is persistent effects, inhibition cholinesterase (ChE) activity a protective metric OP exposure. This study examined chronic dietary repeated high-level exposure to pesticide chlorpyrifos (diethyl 3,5,6-trichloro-2-pyridyl phosphorothionate, CPF) on...
With the abundance of chemicals in environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays. This study evaluated developmental toxicity behavioral effects 61 zebrafish (Danio rerio) larvae using Light/Dark assay. Larvae (n = 16–24 per concentration) were exposed to each (0.0001–120 μM) during development locomotor activity was assessed. Approximately half 30) did not show any gross (i.e., mortality, dysmorphology...
The use of larval zebrafish developmental testing and assessment, specifically locomotor activity, has been recognized as a higher throughput strategy to identify developmentally toxic neurotoxic chemicals. There are, however, no standardized protocols for this type assay, which could result in confounding variables being overlooked. Two chemicals commonly employed during early-life stage assays, methylene blue (antifungal agent) dimethyl sulfoxide (DMSO, used vehicle) have reported affect...
Very little is known about the effects of chronic exposure to relatively low levels anticholinesterase insecticides or how compare those higher, intermittent exposure. To that end, adult male rats were fed an insecticide, chlorpyrifos (CPF), for 1 year at three dietary exposure: 0, 1, 5 mg/kg/day (0+oil, 1+oil, and 5+oil). In addition, half each these groups also received a bolus dosage CPF in corn oil ("spiked" animals; 60 mg/kg initially 45 thereafter) every 2 months (0+CPF, 1+CPF, 5+CPF)....
Combustion of mixed materials during open air burning refuse or structural fires in the wildland urban interface produces emissions that worsen quality, contaminate rivers and streams, cause poor health outcomes including developmental effects. The zebrafish, a freshwater fish, is useful model for quickly screening toxicological effects agents such species elicits biological responses are often analogous predictive mammals. purpose this study was to compare toxicity smoke derived from 5...
Exposure to fine particulate matter (PM) air pollution causes adverse cardiopulmonary outcomes. Yet, the limited capacity readily identify contributing PM sources and associated constituents in any given ambient shed impedes risk assessment efforts. The health effects of have been attributed part its elicit irritant responses. A variety chemicals trigger behavior responses zebrafish that can be easily measured. purposes this study were examine utility locomotor toxicity chemical fractions...
The cholinesterases (acetylcholinesterase and butyrylcholinesterase)In this chapter, cholinesterase will be used to refer both enzymes together (i.e., total cholinesterase), whereas acetylcholinesterase or butyrylcholinesterase when referring the specific esterase.