A5028231173- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Photodynamic Therapy Research Studies
- Colorectal and Anal Carcinomas
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Phytochemicals and Antioxidant Activities
- Diet and metabolism studies
- Bone health and treatments
- Colorectal Cancer Surgical Treatments
- Nuclear Physics and Applications
- Mathematical Biology Tumor Growth
- HER2/EGFR in Cancer Research
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Edible Oils Quality and Analysis
- Boron Compounds in Chemistry
- Effects of Radiation Exposure
- Cancer, Lipids, and Metabolism
- Cancer Cells and Metastasis
- Metastasis and carcinoma case studies
- Nanoplatforms for cancer theranostics
- Photoacoustic and Ultrasonic Imaging
- Histone Deacetylase Inhibitors Research
University of Florence
2010-2024
Boron neutron capture therapy (BNCT) is an anticancer based on the incorporation of 10B in tumors, followed by irradiation. Recently, synthesis and delivery new boronated compounds have been recognized as some main challenges BNCT application. Here, we report use liposomes carriers for active compounds. Two carborane derivatives, i.e., o-closocarboranyl β-lactoside (LCOB) 1-methyl-o-closocarboranyl-2-hexylthioporphyrazine (H2PzCOB), were loaded into bearing different surface charges. The...
We have found that the anti-apoptotic Bcl-2 family protein, Bcl-w, was frequently expressed in colorectal adenocarcinomas, with 69/75 showing positive staining anti-Bcl-w IgG. Adenomas demonstrated a much lower frequency of Bcl-w expression (only 1 17), as did adenocarcinomas from other epithelial tissues such breast (0/8), stomach (1112) and cervix (0/12). status could be related to histopathological classification tumours, TNM stage III tumours significantly higher levels than better...
Neuroblastoma (NB) is the most common extra-cranial solid tumour in infants. Unfortunately, children present with advanced disease and have a poor prognosis. There vitro evidence that peroxisome proliferator-activated receptor γ (PPARγ) might be target for pharmacological intervention NB. We previously demonstrated PPARγ agonist rosiglitazone (RGZ) exerts strong anti-tumoural effects human NB cell line, SK-N-AS. The aim of this study was to evaluate whether RGZ maintains its against SK-N-AS...
The prognosis of colorectal cancer depends on the stage disease. However, even within same there may be different outcomes in terms recurrence and survival. Therefore, it is clear that as well pathological stage, novel biomarkers are capable improving risk stratification therapeutic decision‑making required. present study aimed to evaluate potential roles two previously proposed tumour status: B‑cell lymphoma 2 (Bcl‑2) β‑catenin. A total 412 patients undergoing surgery for primary were...
Aim: The objective of this study was to investigate the possible synergy between doxycycline and photodynamic therapy against Helicobacter pylori evaluate side effects on adenocarcinoma gastric cells with without protoporphyrin IX. Materials & methods: Three H. strains (ATCC 700392, 43504 49503) were grown solid medium either with, or without, at subinhibitory concentrations, irradiated for 10, 20 30 minutes a 400 nm-peaked light source. phototoxicity tests AGS evaluated by MTT assay....
1. The comparative study of the effect bradykinin (BK) in young and old IMR-90 human fibroblasts shows that cells are characterized by a reduced increase 1,2-diacylglycerol (1,2-DAG) generation upon stimulation after short-term treatment significant higher long-term agonist treatment. BK-induced activation phospholipase D (PLD), major enzyme involved sustained 1,2-DAG generation, was 2.5-fold cells, strongly suggesting it is potentiated formation. increased PLD BK specific, since parallel...
Pâté is a by-product of olive oil production which represents an abundant source phenolic compounds and can be used for food formulation, reducing its environmental impact promoting circular economy. In this context, the effects hydroalcoholic extract pâté were evaluated first time in AGS human cell line commonly as model gastric mucosa. was obtained from Tuscan olives; total content 16.6 mg/g dried extract, with verbascoside secoiridoid derivatives most phenols. The did not alter viability,...
The effects of the phenolic compounds extra virgin olive oil (EVOO) on AGS cells have never been studied so far, which is aim this study. profiles main components in EVOOs, mainly secoiridoid derived from transformation oleuropein during milling process, were evaluated and compared. Oils different origins aiming at verifying whether chemical differences composition dry extracts played a role metabolism maintaining cellular redox state cells. following key enzymes some metabolic pathways...
Head and neck squamous cell carcinomas (HNSCC) are a diverse group of tumors with high morbidity mortality that have remained mostly unchanged over the past decades. The epidermal growth factor receptor (EGFR) is often overexpressed activated in these strongly contributes to their pathogenesis. Still, EGFR-targeted therapies such as monoclonal antibodies kinase inhibitors demonstrated only limited improvements clinical outcome this disease. Here, we take advantage extraordinary affinity EGF...
Helicobacter pylori gastric infections are among the most diffused worldwide, suffering from a rising rate of antibiotic resistance. In this context, some authors have previously designed an ingestible device in form luminous capsule to perform antibacterial photodynamic inactivation stomach. study, light-emitting capsules were tested verify safety use prior clinical efficacy studies. First, laboratory tests measured temperature while function and verified its chemical resistance conditions...
Abstract Here is presented a setup made of combination an injection valve, hand‐made chromatographic microcolumn and electrochemical detector for the simultaneous separation Hg 2+ Ag + ions in water. The microcolumns were packed with exchanger resin used ions, whereas screen‐printed carbon electrode (SPCE) was amperometric detector. performances SPCE towards firstly studied FIA setup. efficiency ion then evaluated. reproducibility, stability, regeneration obtained also discussed.
Spartium junceum L. is a typical species of Mediterranean shrubland areas, also grown in gardens and parks as an ornamental. In recent years Europe, S. has been recurrently found to be infected by different subspecies genotypes the quarantine regulated bacterium Xylella fastidiosa (Xf). This work presents for first time anatomy plants that we found, means genetic immunochemistry analysis, naturally Xf subsp. multiplex ST87 (XfmST87) Monte Argentario (Grosseto, Tuscany, Italy), new outbreak...
In the framework of increasing phenomenon antibiotic-resistant infections, those caused by Helicobacter pylori (Hp) have a particular significance, being worldwide diffused and associated with severe pathologies, among which gastric cancer. To overcome antibiotic-resistance, we propose use photodynamic therapy (PDT), based upon cytotoxic species production following bacteria illumination visible light. case Hp infection, this is due to presence endogenous light absorbers (porphyrins)....