A5101912094- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Tracheal and airway disorders
- Congenital Diaphragmatic Hernia Studies
- Cardiac Valve Diseases and Treatments
- Aortic Disease and Treatment Approaches
- Mechanical Circulatory Support Devices
- Coronary Artery Anomalies
- Vascular anomalies and interventions
- Biofuel production and bioconversion
- Cardiac Arrest and Resuscitation
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Issues in Pregnancy
- Retinoids in leukemia and cellular processes
- Cardiovascular Effects of Exercise
- Sepsis Diagnosis and Treatment
- Augmented Reality Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Anatomy and Medical Technology
- Acute Myeloid Leukemia Research
- Renal and Vascular Pathologies
- Pluripotent Stem Cells Research
- Infective Endocarditis Diagnosis and Management
- Trauma Management and Diagnosis
- Surgical Simulation and Training
Pusan National University Yangsan Hospital
2016-2025
Weatherford College
2021
Pusan National University
2011-2015
Macrogen (South Korea)
2004-2014
Keimyung University
2014
Ajou University
2010
Seoul National University
2010
Phillips Academy
2009
Michigan State University
2009
RIKEN BioResource Research Center
2001-2003
Greenhouse gas release from land use change (the so-called "carbon debt") has been identified as a potentially significant contributor to the environmental profile of biofuels. The time required for biofuels overcome this carbon debt due and begin providing cumulative greenhouse benefits is referred "payback period" estimated be 100-1000 years depending on specific ecosystem involved in event. Two mechanisms exist: "direct" change, which occurs part supply chain biofuel production facility,...
We report the complete genome sequence of Zymomonas mobilis ZM4 (ATCC31821), an ethanologenic microorganism interest for production fuel ethanol. The consists 2,056,416 base pairs forming a circular chromosome with 1,998 open reading frames (ORFs) and three ribosomal RNA transcription units. lacks recognizable genes 6-phosphofructokinase, essential enzyme in Embden-Meyerhof-Parnas pathway, two enzymes tricarboxylic acid cycle, 2-oxoglutarate dehydrogenase complex malate dehydrogenase, so...
Abstract Reprogramming of somatic cells to induced pluripotent stem involves a dynamic rearrangement the epigenetic landscape. To characterize this epigenomic roadmap, we have performed MethylC-seq, ChIP-seq (H3K4/K27/K36me3) and RNA-Seq on samples taken at several time points during murine secondary reprogramming as part Project Grandiose. We find that DNA methylation gain occurs gradually, while loss is achieved only ESC-like state. Binding sites activated factors exhibit focal...
Bioethanol has been recognized as a potential alternative energy source. Among various ethanol-producing microbes, Zymomonas mobilis acquired special attention due to its higher ethanol yield and tolerance. However, cellular metabolism in Z. remains unclear, hindering practical application for bioethanol production. To elucidate such physiological characteristics, we reconstructed validated genome-scale metabolic network (iZM363) of ATCC31821 (ZM4) based on annotated genome biochemical...
This study was undertaken to assess the early and long-term results of total repair tetralogy Fallot (TOF) identify risk factors associated with late right ventricular (RV) dilatation.The medical records 326 patients (male:female = 192:134) who underwent TOF at Pusan National Dong-A University Hospitals between July 1991 May 2011 were retrospectively reviewed. Median age weight time operation 13.0 months 8.7 kg, respectively. Right end-diastolic dimensions left obtained during follow-up...
Doxorubicin (DOXO) is widely used to treat solid tumors. However, its clinical use limited by side effects including serious cardiotoxicity due cardiomyocyte damage. Resident cardiac progenitor cells (hCPCs) act as key regulators of homeostasis in myocardial cells. little known about the function hCPCs DOXO-induced cardiotoxicity. In this study, we found that DOXO-mediated hCPC toxicity closely related calcium-related autophagy signaling and was significantly attenuated blocking mTOR human...
The mammalian target of rapamycin (mTOR) signaling pathway efficiently regulates the energy state cells and maintains tissue homeostasis. Dysregulation mTOR has been implicated in several human diseases. Rapamycin is a specific inhibitor pharmacological inhibition with promote cardiac cell generation from differentiation mouse embryonic stem cells. These studies strongly implicate role sustained activity differentiating functions cells; however, they do not directly address required effect...
Background Currently, no ideal prosthesis is available for right ventricular outflow tract (RVOT) reconstruction in neonates and young infants. Therefore, we developed a 10-mm handmade monocusp expanded polytetrafluoroethylene (ePTFE) valved conduit report our experience. Methods A retrospective clinical review was conducted on 11 consecutive patients who underwent RVOT with ePTFE since May 2018. Six definitive Rastelli operation, five palliative ventricle-to-pulmonary artery formation. The...
A fusion between the promyelocytic leukemia (PML) protein and retinoic acid receptor-α (RARα) results in transforming of acute leukemia, PML-RARα. PML has growth-suppressive properties is localized within distinct nuclear structures referred to as bodies. participates numerous cellular functions, including transcriptional activation, apoptosis, repression, whereas PML-RARα blocks these functions. However, role played by leukemogenesis remains unclear. Here we report that required for...
Cardiac progenitor cells (CPCs) are resident stem present in a small portion of ischemic hearts and function repairing the damaged heart tissue. Intense oxidative stress impairs cell metabolism thereby decreasing viability. Protecting CPCs from undergoing cellular apoptosis during is crucial optimizing CPC-based therapy. Histochrome (sodium salt echinochrome A-a common sea urchin pigment) an antioxidant drug that has been clinically used as pharmacologic agent for ischemia/reperfusion injury...
Ski is a transcriptional co-repressor and involved in the negative regulation of tumor growth factor-β (TGF-β) signaling. To understand more fully role TGF-β signaling, we searched for novel Ski-interacting proteins. The identified C184M protein consists 189 amino acids contains leucine-rich region. An association between involving region C-terminal coiled-coil motif was confirmed by glutathione S-transferase pull-down immunoprecipitation assays. located cytosol, signals are co-localized...
We investigated the effect of balloon pulmonary valvuloplasty (BPV) as a palliative procedure for patients with tetralogy Fallot (TOF).This was retrospective single-center study conducted between 2008 and 2014. classified into three groups according to palliation: treatment BPV (group I), Blalock-Taussig shunt II), infundibulectomy III). The growth valve (PV) annulus need transannular patching (TAP) during total correction were compared groups.Forty-eight enrolled: 31, 10, 7 in I, II, III,...
Abstract rck/p54 is a DEAD‐box RNA helicase protein with ATP‐dependent RNA‐unwinding activity. Its ortholog required for sexual reproduction in yeast and oocyte survival sperm fertility Caenorhabditis elegans . In the current study, we investigated expression of mouse gametogenesis early embryogenesis. Western blot analysis revealed that was highly expressed both ovary testis. ovary, maturing oocytes strongly their cytoplasm. contrast, testis, spermatogonia primary spermatocytes cytoplasm,...
We report the results of a bicuspid expanded polytetrafluoroethylene (ePTFE) valved conduit used for right ventricular outflow tract reconstruction (RVOTR).Between November 2005 and February 2009, 12 conduits were RVOTR. The mean age weight patients 43.5 ± 46.4 months 13.4 8.6 kg. main diagnosis was tetralogy Fallot with pulmonary atresia in eight patients. most common size 18 mm. follow-up 88.0 35.9 months.There no operative late mortalities. At discharge, peak systolic pressure gradient...
The surgical management of transposition complex with aortic arch obstruction remains technically demanding due to anatomic complexity. Even in the recent era, there are centers that address this anomaly a staged strategy. This report presents our experiences one-stage repair complexes obstructions more than last 10 years. Since 2003, 19 patients great arteries (TGA, 2 patients) or double outlet right ventricle (DORV, 17 and have undergone their anomalies. mean age was 6.7 ± 2.3 days, body...
Abstract In this study, we sought predictors of mortality in children with acute myocarditis and incomplete recovery the survivor group. We classified our patients into three groups according to their outcomes at last follow-up: full was as group I, II, death III. total, 55 were enrolled study: 33 11 The initial left ventricular fractional shortening – significantly lower III (p=0.001), end-diastolic dimension z score higher II compared I (p=0.000). A multivariate analysis showed that (odds...
We adopted an operative technique of pulmonary valve (PV) annular enlargement with repair in tetralogy Fallot (TOF) correction to reduce postoperative regurgitation (PR) 16 years ago. Here, we have evaluated the long-term results. Between April 2000 and August 2005, 43 patients (26 men) stenosis underwent PV repair. The median age body weight at time surgery were 14 months 10.2 kg, respectively. There was no mortality. Mean PR grade discharge 0.93 ± 0.40 (none or trivial 10 patients, mild 27...