A5059174521- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Immune cells in cancer
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Immune Cell Function and Interaction
- Kruppel-like factors research
- Radiomics and Machine Learning in Medical Imaging
- CAR-T cell therapy research
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer-related gene regulation
- Cell Adhesion Molecules Research
- Bone Metabolism and Diseases
- Chemokine receptors and signaling
- Monoclonal and Polyclonal Antibodies Research
Fujian Medical University
2008-2025
Fudan University Shanghai Cancer Center
2021-2025
Fujian Provincial Cancer Hospital
2019-2025
Fudan University
1999-2024
Imperial College London
2023
Center for High Pressure Science & Technology Advanced Research
2021
First Affiliated Hospital of Fujian Medical University
2017-2020
Fuzhou University
2020
City Of Hope National Medical Center
2014
Glioma groups, including lower-grade glioma (LGG) and glioblastoma multiforme (GBM), are the most common primary brain tumor. Malignant gliomas, especially glioblastomas, associated with a dismal prognosis. Hypoxia is driver of malignant phenotype in groups; it triggers cascade immunosuppressive processes cellular responses (tumor progression, anti-apoptosis, resistance to chemoradiotherapy), which result disease progression poor However, approaches determine extent hypoxia tumor...
Abstract The recently described role of RNA methylation in regulating immune cell infiltration into tumors has attracted interest, given its potential impact on immunotherapy response. YTHDF1 is a versatile and powerful m6A reader, but the understanding evasion limited. Here, we reveal that tumor-intrinsic drives checkpoint inhibitor (ICI) resistance. Additionally, deficiency converts cold responsive hot tumors, which improves ICI efficacy. Mechanistically, inhibits translation lysosomal...
Rationale: Accumulating evidence supports the importance of radiation therapy in induction antitumor immunity. Small extracellular vesicles (sEVs) play essential roles tumor antigen loading and delivery. However, role sEVs radiation-induced immunity remains unclear. It is therefore important to determine regulatory mechanisms Methods: Tumor cells were irradiated (8 Gy), purified via ultracentrifugation. Primary experimental lung metastasis models established mice evaluate triggered by...
Abstract Tribbles pseudokinase 3 (TRIB3) has been identified recently as a novel oncogene in several cancers. Still, further extensive research is imperative to elucidate its function and the molecular mechanisms underlying involvement progression of head neck squamous cell carcinoma (HNSCC). In our study, we found that TRIB3 silencing significantly promoted death by inducing ferroptosis. The interaction with Transcription Factor 4 (TCF4) β-catenin created heterotrimeric complex, which...
Tumor-treating fields (TTFields) therapy and radiotherapy may have synergistic anti-glioma effect based on preclinical studies. The combination of chemoradiation (CRT) with TTFields has noticeably attracted clinicians' attention. This study aimed to provide insights into the clinical outcomes patients newly diagnosed glioblastoma who received either concurrent CRT or adjuvant following CRT. findings were a cohort treated at Huashan Hospital (Shanghai, China). retrospective analyzed ndGBM...
Background: Lung cancer is the leading cause of cancer-related death worldwide. Numerous studies have been performed to investigate correlation between epidermal growth factor receptor (EGFR) mutation status and incidence brain metastases (BMs) in patients with non-small cell lung (NSCLC), however, outcomes were inconsistent. Thus, we this study establish role EGFR BMs. Methods: Electronic databases PubMed, Embase, Cochrane Library, CBM, WanFang, CNKI searched identify relevant trials. The...
Although the successful clinical trials of immunotherapy show promising strategies for many cancers, its application in glioma has lagged comparison with progress seen other cancers. Both isocitrate dehydrogenase (IDH) mutations and 1p/19q codeletions are critical molecular alterations affecting therapeutic response lower-grade (LGG). The systematic comprehensive characterization immunological phenotypes different subtypes is key to improving our understanding immunotherapies LGG. Here, we...
<title>Abstract</title> This study investigates the molecular mechanisms underlying acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC). First, we utilized NSCLC cells, organoids (LCOs), xenograft tumor, and patient-derived orthotopic xenografts tumor models establish TKI resistance. Their stem cell-like properties, drug sensitivity, formation vitro vivo transcriptomic profiles were analyzed. The...
Distant metastases occur when non-small cell lung cancer (NSCLC) is at late stages. Bone metastasis one of the most frequent NSCLC and leads to poor prognosis. It has been reported that high expression BMP2 in correlates with survival, but whether contributes bone remains largely unknown. The activation BMP signalling found metastatic tumours mice Lewis carcinoma predicts survival human NSCLC. can enhance carcinoma. Moreover, secreted by stroma fibroblasts promote migration invasion cells....
Abstract CyclinB1 is a regulatory protein involved in mitosis. Multiple lines of evidence indicate that cyclinB1 depletion constrains proliferation and induces apoptosis human tumor cells. The cells become susceptible to suffer critical situation when downregulated. Autophagy major intracellular degradation system recycles nutrients, removes damaged organelles, promotes cell survival under stressful conditions, whereas the role autophagy cyclinB1-deprived neoplastic as well underlying...
Radiotherapy has been widely used for nasopharyngeal carcinoma (NPC) treatment, which causes DNA damage and alterations of macromolecules cancer cells. However, the Raman profile irradiated NPC cells remain unclear. In present study, we laser tweezers spectroscopy (LTRS) to monitor internal structural changes chemical modifications in after exposure at a clinical dose (2.3 Gy) X-ray irradiation (IR) single-cell level. Two types cell lines, CNE2 (EBV-negative line) C666-1 (EBV-positive line),...
Although radiation therapy (RT) plays a critical role in the treatment of low-grade glioma (LGG), many patients suffer from adverse effects without experiencing survival benefits.In various carcinomas, long non-coding RNAs (lncRNAs) contribute to pathogenic processes, including tumorigenesis, metastasis, chemoresistance, and radioresistance.Currently, lncRNAs radiosensitivity LGG is largely unknown.Here, we downloaded clinical data for 167 The Cancer Genome Atlas database divided them...
Malignant glioma, especially glioblastoma, is a highly aggressive disease with dismal prognosis. Vacuole membrane protein 1 (VMP1) critical autophagy-associated roles in oncogenesis and tumor progression. However, the contribution of VMP1 to glioma development as well its prognostic value has not been established.The expression clinicopathologic data for 1996 samples were collected from authoritative public databases explore value. Lentiviral CRISPR-Cas9 gene editing system was performed...
Although the advancement of radiotherapy significantly improves survival nasopharyngeal cancer (NPC), radioresistance associated with recurrence and poor outcomes still remains a daunting challenge in clinical scenario. Currently, effective biomarkers convenient detection methods for predicting have not been well established. Here, surface-enhanced Raman spectroscopy combined proteomics is used to firstly profile characteristic spectral patterns exosomes secreted from self-established NPC...
Inflammatory response is an important characteristic affecting prognosis and therapeutic in lower-grade glioma (LGG). However, the molecular subtypes based on inflammatory are still under exploitation.The RNA sequencing, somatic mutation, corresponding clinical data from 1205 LGG patients were obtained TCGA, CGGA, Rembrandt cohorts. Consensus clustering was performed to identify associated with inflammation. Prognosis, clinicopathologic features, immune cell infiltration, mutation profile...
Radiotherapy is the primary approach for nasopharyngeal carcinoma (NPC). Although high survival rates can be obtained with radiation early stage lesions, distant metastasis and local recurrence frequently occur. In this study, we pioneeringly investigated antitumor activity underlying mechanism of cyclin-dependent kinase 4/6 inhibitor (palbociclib) combined on NPC cells.Evaluation enhancement palbociclib was based results from CCK8 clonogenicity assays cell proliferation, flow cytometry...
Accumulating evidence has supported that osteosarcoma is heterogeneous, and several subtypes have been identified based on genomic profiling. Immunotherapy revolutionizing cancer treatment a promising therapeutic strategy. In contrast, few studies classification immune biosignatures, which offer the optimal stratification of individuals befitting immunotherapy. Here, we classified into two clusters: immunity high low using single-sample gene-set enrichment analysis unsupervised hierarchical...
Abstract Background Nasopharyngeal carcinoma (NPC) treatment is largely based on a ‘one-drug-fits-all’ strategy in patients with similar pathological characteristics. However, given its biological heterogeneity, at the same clinical stage or therapies exhibit significant differences. Thus, novel molecular subgroups these characteristics may better therapeutic outcomes. Methods Herein, 192 treatment-naïve NPC samples corresponding clinicopathological information were obtained from Fujian...
Active immunotherapy is an effective, long-lasting, cheap, and safe approach to suppress cancer progression; however, the key issue develop appropriate tumour vaccines. Oncoproteins are up-regulated under various stress conditions promote cell survival. their immunogenic domains could serve well as vaccines prime hosts' active anti-tumour immunity.Proteomic bioinformatic analyses were performed identify potential associated antigens (TAAs). Then, peptides derived from CD151 designed...
Clear cell renal carcinoma (ccRCC) is a highly aggressive disease and ∼30% of the patients are diagnosed at metastatic stage. Even with new targeted therapies, average progression-free survival overall (OS) rates dismal. Thus, biomarkers for early detection progression could improve outcome. The role C1q/tumor necrosis factor (C1QTNF) family in cancer an emerging field research. However, biological function factor-related protein 6 (C1QTNF6) its prognostic value rarely reported. This study...
B7 homolog 3 (B7-H3) is a recently found superfamily molecule and therefore has significant involvement in immunological regulation. However, the relationships of B7-H3 expression with tumor microenvironment (TME), response to immunotherapy, prognosis head neck squamous cell carcinoma (HNSCC) are still unknown. In present analysis, we determined as novel biomarker that predicts immunotherapy HNSCC. enhanced HNSCC compared normal sample stably expressed line. Besides, high correlated dismal...
Carbon ion radiotherapy (CIRT) may yield satisfactory clinical outcomes for patients who are resistant to radiotherapy. However, the therapeutic impact of carbon ions is still limited in certain recurring or refractory tumors. Therefore, we aimed evaluate synergistic anti-tumor effects immune checkpoint inhibitors (ICIs) combination with CIRT. We then explored involvement ferroptosis a preliminary investigation. A tumor-bearing mouse model was established, and mice were inoculated...
Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a key negative immunoregulatory molecule with characteristics of gene polymorphisms. Genetically predisposed CTLA-4 alteration in humans was associated gastric cancer (GC) development. To explore the association polymorphism susceptibility noncardiac GC (NCGC), 490 NCGC patients and 1476 control individuals were studied. Four polymorphisms genotyped SNPscan genotyping assays haplotypes constructed SHESIS software. Frequencies estimated using an...