A5065888780- Zebrafish Biomedical Research Applications
- Neuroendocrine regulation and behavior
- Animal Behavior and Reproduction
- Receptor Mechanisms and Signaling
- Fish Ecology and Management Studies
- Retinoids in leukemia and cellular processes
- RNA Interference and Gene Delivery
- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Physiological and biochemical adaptations
- RNA Research and Splicing
- Dendrimers and Hyperbranched Polymers
- Retinal Development and Disorders
- Nitric Oxide and Endothelin Effects
- Neurotransmitter Receptor Influence on Behavior
- Congenital heart defects research
- Neurobiology and Insect Physiology Research
- Chemical Synthesis and Analysis
University of Leicester
2015-2020
Universidad de Salamanca
2012-2014
Risperidone is an approved antipsychotic drug belonging to the chemical class of benzisoxazole. This has low solubility in aqueous medium and poor bioavailability due extensive first-pass metabolism high protein binding (>90%). Since new strategies improve efficient treatments are needed, we studied efficiency anionic G4.5 PAMAM dendrimers as nanocarriers for this therapeutic drug. To end, explored dendrimer-risperidone complexation dependence on solvent concentration, pH molar relationship....
Brain developmental disorders in humans, including Autism Spectrum Disorders (ASD) and Down's syndrome, have been linked to increased serotonin levels. This work was designed study changes levels the early stages of development with two classes antipsychotic drugs: Risperidone, a drug that blocks dopamine receptors, fluoxetine, reuptake inhibitor. The use drugs is solid choice decrease increase these neurotransmitters their influence on development. parameters will give an idea effects...
The three-spined stickleback (Gasterosteus aculeatus) is a small teleost fish that ubiquitous across the Northern Hemisphere. Among behaviours have been characterised in this species ritualized courtship, aggressiveness and parental behaviour. Whereas sticklebacks used for ecological, evolutionary, parasitological toxicological research, its complex behavioural repertoire experimental advantages not exploited basic neuroscience research. aim of present study to describe some innate...
Abstract Model fish species such as sticklebacks and zebrafish are frequently used in studies that require DNA to be collected from live animals. This is typically achieved by fin clipping, a procedure simple reliable perform but can harm fish. An alternative sample involves swabbing the skin collect mucus epithelial cells. Although appears less invasive than it still requires netted, held air handled—procedures cause stress. In this study we combine behavioural physiological analyses...
The formation of social groups is an adaptive behaviour that can provide protection from predators, improve foraging and facilitate learning. However, the costs proximity include competition for resources, aggression kleptoparasitism meaning decision whether to interact represents a trade-off. Here we show zebrafish harbouring mutation in endothelin receptor aa (ednraa) form less cohesive shoals than wild-types. ednraa-/- mutants exhibit heightened decreased whole-body cortisol levels...
Aggression is a behavioural trait characterized by the intention to harm others for offensive or defensive purposes. Neurotransmitters such as serotonin and dopamine are important mediators of aggression. However, physiological role histaminergic system during this behaviour currently unclear. Here, we aimed better understand signalling aggression characterizing involvement histamine H3 receptor (Hrh3).
Although aggression is a common symptom of psychiatric disorders the drugs available to treat it are non-specific and can have unwanted side effects. In this study we used behavioural platform in phenotypic screen identify that reduce zebrafish without affecting locomotion. three tier ninety-four discovered caffeine sildenafil selectively aggression. Caffeine also decreased attention increased impulsivity 5-choice serial reaction time task whereas showed opposite effect. Imaging studies...