A5056507504- Autophagy in Disease and Therapy
- CRISPR and Genetic Engineering
- Cell death mechanisms and regulation
- Hippo pathway signaling and YAP/TAZ
- DNA Repair Mechanisms
- Colorectal Cancer Treatments and Studies
- Plant Molecular Biology Research
- Cancer-related Molecular Pathways
- TGF-β signaling in diseases
- Lung Cancer Treatments and Mutations
- Developmental Biology and Gene Regulation
- Cancer Research and Treatments
- Angiogenesis and VEGF in Cancer
- Neurogenesis and neuroplasticity mechanisms
- Melanoma and MAPK Pathways
Institute for Research in Biomedicine
2015-2023
Abstract The formation of new blood vessels is essential for normal development, tissue repair and tumor growth. Here we show that inhibition the kinase p38α enhances angiogenesis in human mouse colon tumors. Mesenchymal cells can contribute to by regulating proliferation migration endothelial cells. We negatively regulates an angiogenic program mesenchymal stem/stromal (MSCs), multipotent progenitors found perivascular locations. This includes acquisition phenotype MSCs mediated both TGF-β...
// Jalaj Gupta 1,* , Ana Igea Marilena Papaioannou 2 Pedro Pablo Lopez-Casas 3 Elisabet Llonch 1 Manuel Hidalgo Vassilis G. Gorgoulis ,4,5 and Angel R. Nebreda 1,6 Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain Department of Histology Embryology, School Medicine, University Athens, Greece Spanish National Cancer Centre (CNIO), Madrid, 4 Biomedical Foundation the Academy 5 Faculty Sciences, Manchester, UK 6 Institució Catalana de Recerca i Estudis Avançats (ICREA), *...
In the adult mammalian brain, most neural stem cells (NSCs) are held in a reversible state of quiescence, which is essential to avoid NSC exhaustion and determine appropriate neurogenesis rate. NSCs mouse subependymal niche provide neurons for olfactory circuits can be found at different depths but very little known on how their quiescence-to-activation transition controlled. Here, we identify atypical cyclin-dependent kinase (CDK) activator RingoA as regulator this process. We show that...
Significance Nearly half of the cases lung cancer bear mutations in RAS pathway. Unfortunately, no specific drugs are available to successfully target many RAS-driven tumors that not surgically resectable. Despite sound rationale for targeting oncogene products therapeutics, this often leads development resistance. As an alternative, nononcogenic proteins can sometimes facilitate tumor progression, and, even though they neither mutated nor overexpressed malignant cells, may represent...
Significance In response to stress, cells can activate several mechanisms that support functionality and survival. However, strong or persistent stresses usually trigger a deleterious answer leads cell death. The protein kinases p38α MK2 are implicated in stress-signaling pathway. Here, we characterize molecular mechanism helps translate the stress-induced activation of p38α–MK2 pathway into appropriate biological responses. We show MK2-expression levels regulated by stress intensity...