A5031925339- Growth Hormone and Insulin-like Growth Factors
- Digestive system and related health
- Nanoparticle-Based Drug Delivery
- Cytokine Signaling Pathways and Interactions
- Metabolism, Diabetes, and Cancer
- PI3K/AKT/mTOR signaling in cancer
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Treatment and Pharmacology
- Sarcoidosis and Beryllium Toxicity Research
- Liver physiology and pathology
- Pancreatic function and diabetes
- Cancer, Hypoxia, and Metabolism
- Estrogen and related hormone effects
- Blood Pressure and Hypertension Studies
- Melanoma and MAPK Pathways
- RNA Interference and Gene Delivery
- Medical Imaging and Pathology Studies
- Nutritional Studies and Diet
- Protein Kinase Regulation and GTPase Signaling
- Nanoplatforms for cancer theranostics
- Protein Interaction Studies and Fluorescence Analysis
- Esophageal and GI Pathology
- Advanced Breast Cancer Therapies
- Breast Cancer Treatment Studies
- Carcinogens and Genotoxicity Assessment
Instituto de Química y Fisicoquímica Biológicas
2012-2024
University of Buenos Aires
2013-2024
Consejo Nacional de Investigaciones Científicas y Técnicas
2011-2024
Universidad Nacional de Córdoba
2024
Instituto de Investigación Médica Mercedes y Martín Ferreyra
2024
Hospital Muñiz
2023
Institute for Research in Biomedicine
2023
Institute for Research in Biomedicine
2019-2023
Hospital Universitario de Torrejón
2023
Complejo Hospitalario de Pontevedra
2022
Abstract The formation of new blood vessels is essential for normal development, tissue repair and tumor growth. Here we show that inhibition the kinase p38α enhances angiogenesis in human mouse colon tumors. Mesenchymal cells can contribute to by regulating proliferation migration endothelial cells. We negatively regulates an angiogenic program mesenchymal stem/stromal (MSCs), multipotent progenitors found perivascular locations. This includes acquisition phenotype MSCs mediated both TGF-β...
Prolactin (PRL) stimulates breast cancer cell proliferation; however, the involvement of PRL-activated signaling molecules in proliferation is not fully established. Here we studied role c-Src on PRL-stimulated T47D and MCF7 cells. We initially observed that PRL-dependent activation focal adhesion kinase (Fak), Erk1/2, was mediated by cells, because expression a dominant-negative form (SrcDM, K295A/Y527F) blocked effects. The Src inhibitor PP1 abrogated vivo Fak, p70S6K, Akt cells; Janus 2...
To study the role of c-Src in breast cancer tumorigenesis, we generated a cell line derived from MCF7 carrying an inducible dominant negative (c-SrcDN: K295M/Y527F) under tetracycline control (Tet-On system). c-SrcDN expression caused phenotypic changes, relocation c-Src, Fak, and paxillin, loss correct actin fiber assembly. These alterations were coupled to increased Fak-Tyr(397) autophosphorylation inhibition Fak-Tyr(925), p130(CAS), paxillin phosphorylation. An association total Src with...
Growth hormone (GH) overexpression throughout life in transgenic mice is associated with the development of liver tumors at old ages. The preneoplastic pathology observed young adult GH-overexpressing similar to that present humans high risk hepatic cancer. To elucidate molecular pathogenesis underlying pro-oncogenic induced by prolonged exposure elevated GH levels, activation and expression several components signal transduction pathways have been implicated hepatocellular carcinogenesis...
Lecithins, mainly composed of the phospholipids phosphatidylcholines (PC), have many different uses in pharmaceutical and clinical field. PC are involved structural biological functions as membrane trafficking processes cellular signaling. Considering increasing applications lecithin-based nanosystems for delivery therapeutic agents, aim present work was to determine effects phosphatidylcholine nanoparticles over breast cancer proliferation dispersions at 0.01 0.1% (w/v) prepared buffer pH...
Nanomedicines have become an attractive platform for the development of novel drug delivery systems in cancer chemotherapy. Polymeric nanoparticles (NPs) represent one best well-investigated nanosized carriers antineoplastic compounds. The "Pegylation strategy" has been used order to improve carrier biodistribution, however, some with PEG on their surface exhibited poorly-cellular internalization. In this context, purpose present study was compare vitro performance two paclitaxel...
Chronically elevated levels of GH in GH-transgenic mice result accelerated growth and increased adult body weight. We have previously described that the GH-induced JAK2/STAT5-signaling pathway is desensitized liver transgenic overexpressing GH. However, these animals present circulating IGF-I levels, hepatic GHR expression, organomegaly due to hypertrophy hyperplasia, which frequently progress hepatomas as age, indicating action on not prevented. In study, we evaluated other GH-signaling...
Epidermal growth factor (EGF) is a key regulator of cell survival and proliferation involved in the pathogenesis progression different types cancer. The EGF receptor (EGFR) activated by binding specific ligand but also transactivation triggered factors including GH. Chronically, elevated GH levels have been associated with hepatocellular carcinoma. Considering involvement their signaling crosstalk, objective present study was to analyze modulatory effects on liver. For this purpose,...
Microemulsions (MEs) were designed by an innovative rational development, characterized, and used to load up 20 mM of Tamoxifen citrate (TMX). They made with acceptable well-characterized excipients for all the routes administration. Some their properties, such as nanometric mean size long stability shelf life, make them interesting drug delivery systems. The results obtained after in vitro inhibition estradiol-induced proliferation MCF-7 breast cancer cells demonstrated a significant effect...
p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of signaling has been linked several diseases including inflammation, immune disorders cancer, suggesting targeting could be therapeutically beneficial. Over last two decades, inhibitors have developed, which showed promising effects pre-clinical studies but results from clinical trials disappointing, fueling interest generation alternative...