A5028775676- Photochromic and Fluorescence Chemistry
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- X-ray Diffraction in Crystallography
- Receptor Mechanisms and Signaling
- Crystallization and Solubility Studies
- Phytochemistry and biological activities of Ficus species
- Axial and Atropisomeric Chirality Synthesis
- Computational Drug Discovery Methods
- Protein Kinase Regulation and GTPase Signaling
- Synthesis of Organic Compounds
- Melanoma and MAPK Pathways
Institute for Research in Biomedicine
2023
Institute of Advanced Chemistry of Catalonia
2020-2022
Imperial College London
2022
Catecholamine-triggered β-adrenoceptor (β-AR) signaling is essential for the correct functioning of heart. Although both β1 - and β2 -AR subtypes are expressed in cardiomyocytes, drugs selectively targeting have proven this receptor as main target therapeutic effects beta blockers Here, we report a new strategy light-control activation by means photoswitchable with high level -/β2 selectivity. All reported molecules allow an efficient real-time optical control function vitro. Moreover, using...
β2-Adrenoceptors (β2-AR) are prototypical G-protein-coupled receptors and important pharmacological targets with relevant roles in physiological processes diseases. Herein, we introduce Photoazolol-1–3, a series of photoswitchable azobenzene β2-AR antagonists that can be reversibly controlled light. These new photochromic ligands designed following the azologization strategy, p-acetamido substituting hydrophobic moiety present many antagonists. Using fluorescence resonance energy transfer...
p38α is a versatile protein kinase that can control numerous processes and plays important roles in the cellular responses to stress. Dysregulation of signaling has been linked several diseases including inflammation, immune disorders cancer, suggesting targeting could be therapeutically beneficial. Over last two decades, inhibitors have developed, which showed promising effects pre-clinical studies but results from clinical trials disappointing, fueling interest generation alternative...
Adrenoceptors are G protein-coupled receptors involved in a large variety of physiological processes, also under pathological conditions. This is due part to their ubiquitous expression the body exerting numerous essential functions. Therefore, possibility control activity with high spatial and temporal precision would constitute valuable research tool. In this study, we present caged version approved non-selective β-adrenoceptor antagonist carvedilol, synthesized by alkylation its secondary...
We report an improved total synthesis of 4,5-dibromo-9,10-dihydrophenanthrene-2,3,6,7-tetraol, (±)-polysiphenol, via intermolecular McMurray dimerization 5-bromovanillin and subsequent intramolecular oxidative coupling as the key steps. The synthetic route is applicable to 4,5-dichloro- 4,5-difluoro-halologues (as well a 4,5-dialkyl-analogue). Distinctive AA'BB' multiplets in their 1H NMR spectra for dimethylene bridges dibromo dichloro compounds reveal them be room-temperature stable...
Abstract Catecholamine‐triggered β‐adrenoceptor (β‐AR) signaling is essential for the correct functioning of heart. Although both β 1 ‐ and 2 ‐AR subtypes are expressed in cardiomyocytes, drugs selectively targeting have proven this receptor as main target therapeutic effects beta blockers Here, we report a new strategy light‐control activation by means photoswitchable with high level ‐/β selectivity. All reported molecules allow an efficient real‐time optical control function vitro....
Summary Catecholamine-triggered β-adrenoceptor (β-AR) signaling is essential for the correct functioning of heart. Although both β 1 - and 2 -AR subtypes are expressed in cardiomyocytes, drugs selectively targeting have proven this receptor as main target therapeutic effects beta blockers Here, we report a new strategy spatiotemporal control activation by means light-regulated with high level -/β selectivity. All reported molecules allow an efficient real time optical function vitro....