A5065390944- Immune cells in cancer
- Inflammatory Biomarkers in Disease Prognosis
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- interferon and immune responses
- Inflammation biomarkers and pathways
- Reproductive System and Pregnancy
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Complement system in diseases
- Barrier Structure and Function Studies
- Cytomegalovirus and herpesvirus research
- Cancer, Hypoxia, and Metabolism
- Blood groups and transfusion
- Immunotherapy and Immune Responses
- Pharmacological Effects of Natural Compounds
University of Crete
2012-2019
Cardiff University
2009
University of Pennsylvania
2008
Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of with immunosuppressive properties and might confer to worse prognosis in cancer patients. The presence phenotypically newly described subpopulations MDSCs their association the clinical outcome were investigated non-small cell lung (NSCLC) percentages correlation between distinct immune peripheral blood 110 chemotherapy-naive patients before treatment healthy controls using flow cytometry. Two monocytic [CD14 +...
Abstract Presentation in trans by the Interleukin‐15 receptor α chain (IL‐15Rα) has been suggested as main mechanism for IL‐15 anchoring to cell surface, but it is also evident that can exist a transmembrane protein. We herein demonstrate replacement of first 41 residues human (hIL‐15) with Ig κ leader sequence resulted secretion most recombinant hIL‐15 expressed transfectant cells, thus identifying region IL‐15. A fusion protein (hIL‐15Rα‐Fc) between extracellular domain hIL‐15Rα and Fc...
Abstract Background: The detection of circulating tumor cells (CTCs) in peripheral blood (PB) breast cancer (BC) patients is an unfavourable prognostic factor; however further characterization these required to understand their biological role. presence stemness and epithelial-to-mesenchymal transition (EMT) markers CTCs could be important marker enhanced metastatic capacity. On the other hand, myeloid-derived suppressor (MDSCs) T regulatory (Tregs) play essential role tumor-immune evasion,...
Abstract In our previous study, high levels of one granulocytic (G-MDSC) and two monocytic (M-MDSCs) subpopulations immunosuppressive MDSCs were found their overexpression was correlated with worse prognosis in NSCLC patients. Using flow cytometry, the impact chemotherapy on percentages functionality M-MDSC (CD14+CD15-CD11b+CD33+HLA-DR-Lin- CD14+CD15+CD11b+ CD33+HLA-DR-Lin-) G-MDSC (CD14-CD15+CD11b+CD33+HLA-DR-Lin-) evaluated peripheral blood patients (n=141) prior to after 3rd 6th cycle...
Abstract Background: The immune system can either prevent and control the tumor growth or promote escape. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature with suppressive properties their overexpression seems to confer worse prognosis in cancer patients. Objective: aim study was investigate presence new phenotypically subpopulations MDSCs which could be associated advanced/metastatic NSCLC patients' clinical outcome. Materials & Methods:...
e14639 Background: Immune suppressive cells,Myeloid-Derived Suppressor Cells (MDSCs) and T Regulatory (Tregs) have been identified as negative prognostic biomarkers in distinct solid tumors. In colorectal cancer (CRC), increased peripheral levels of MDSCs correlated to worse survival (Solito S et al.; Blood 2011). Although Tregs infiltrated tumors associated with favourable clinical outcome (Salama P JCO 2009), their significance blood remains unclear. The aim the present study was evaluate...