A5048661154- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organometallic Complex Synthesis and Catalysis
- Ferrocene Chemistry and Applications
- Metal complexes synthesis and properties
- Crystallography and molecular interactions
- Nanoparticles: synthesis and applications
- Cholinesterase and Neurodegenerative Diseases
- Catalytic C–H Functionalization Methods
- Radical Photochemical Reactions
- Fluorine in Organic Chemistry
- Advanced battery technologies research
- Organic Chemistry Cycloaddition Reactions
- Oxidative Organic Chemistry Reactions
- Metal-Catalyzed Oxygenation Mechanisms
- Click Chemistry and Applications
- Asymmetric Hydrogenation and Catalysis
- Advanced Nanomaterials in Catalysis
University of Łódź
2015-2024
École Nationale Supérieure de Chimie de Montpellier
2022
Université de Montpellier
2022
Centre National de la Recherche Scientifique
2022
In these studies, we designed and investigated cyto- genotoxic potential of five ruthenium cyclopentadienyl complexes bearing different phosphine phosphite ligands. All the were characterized with spectroscopic analysis (NMR, FT-IR, ESI-MS, UV-vis, fluorescence XRD (for two compounds)). For biological used three types cells - normal peripheral blood mononuclear (PBM) cells, leukemic HL-60 doxorubicin-resistance (HL-60/DR). We compared results obtained those for complex maleimide ligand...
Abstract In these studies, we designed and investigated the potential anticancer activity of five iron(II) cyclopentadienyl complexes bearing different phosphine phosphite ligands. All were characterized with spectroscopic analysis viz. NMR, FT–IR, ESI–MS, UV–Vis, fluorescence, XRD (for four complexes) elemental analyses. For biological used three types cells—normal peripheral blood mononuclear (PBM) cells, leukemic HL-60 cells non-small-cell lung cancer A549 cells. We evaluated cell...
Abstract In these studies, we investigated a cytotoxic and genotoxic potential of four ruthenium cyclopentadienyl complexes bearing different imidato ligands: ( η 5 ‐cyclopentadienyl)Ru (CO) 2 1 ‐ N ‐maleimidato) ), ‐methoxysuccinimidato ‐ethoxysuccinimidato 3 ‐phthalimidato 4 ). We used two types cells—normal peripheral blood mononuclear cells (PBMCs) leukemic HL‐60 cells. observed that complex was highly genotoxic, both for normal cancer at concentrations from 0.5 to 250 μM. Interestingly,...
In these studies, we investigated the antioxidant activity of three ruthenium cyclopentadienyl complexes bearing different imidato ligands: (η5-cyclopentadienyl)Ru(CO)2-N-methoxysuccinimidato (1), (η5-cyclopentadienyl)Ru(CO)2-N-ethoxysuccinimidato (2), and (η5-cyclopentadienyl)Ru(CO)2-N-phthalimidato (3). We studied effects 1-3 at a low concentration 50 µM on viability cell cycle peripheral blood mononuclear cells (PBMCs) HL-60 leukemic exposed to oxidative stress induced by hydrogen...
The quest to find new inhibitors of biologically relevant targets is considered an important strategy introduce drug candidates for the treatment neurodegenerative diseases. A series (aminomethyl)benzylphosphonates 8a-c and their metallocarbonyl iron 9a-c ruthenium 10a-c complexes were designed, synthesized, evaluated inhibitory potentials against acetylcholinesterase (AChE) butyrylcholinesterase (BuChE) by determination IC50. Metallocarbonyl derivatives, in general, did not show significant...
Succinimides are among the most studied compounds due to their wide profile of biological activities. It is well-known that succinimides undergo ring-opening reactions under alkaline conditions. This feature limits formation 3-substituted from maleimides by an oxa-Michael reaction, for which basic conditions required. Herein, we report synthesis, characterization, and crystal structure metallocarbonyl (Fe, Ru) complexes bearing succinimide ligands. These were obtained in...
Amines significantly accelerate iodide substitution in CpFe(CO) 2 I with phosphines.
2-Propoxythioxanthen-9-one (1), 2-chloro-4-methylthioxanthen-9-one (2) and tributylstannyloxythioxanthene (3) were reduced to 2-propoxythioxanthen (1′), 2-chloro-4-methylthioxanthen (2′) thioxanthen (3′) using dibutyltin chloro hydride. The mechanism of this reaction involving formation tributylstannyloxythioxanthyl ketyl radical has been suggested by comparison products hydrostannation three studied thioxanthene derivatives.