A5006046050- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Polyoxometalates: Synthesis and Applications
- Catalytic Cross-Coupling Reactions
- Photochromic and Fluorescence Chemistry
- Gold and Silver Nanoparticles Synthesis and Applications
- X-ray Diffraction in Crystallography
- Advanced Polymer Synthesis and Characterization
- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Hydrogels: synthesis, properties, applications
- Graphene and Nanomaterials Applications
- Synthetic Organic Chemistry Methods
- Molecular Sensors and Ion Detection
- Nanocluster Synthesis and Applications
- Chemotherapy-induced cardiotoxicity and mitigation
- Chemical Synthesis and Analysis
- Lanthanide and Transition Metal Complexes
- Supramolecular Self-Assembly in Materials
- Micro and Nano Robotics
- Advanced Drug Delivery Systems
- Advanced biosensing and bioanalysis techniques
- Iron oxide chemistry and applications
- Pickering emulsions and particle stabilization
University of Białystok
2014-2024
Faculty (United Kingdom)
2020
Université de Toulouse
2020
Softmat - Chimie des colloïdes, polymères & assemblages complexes
2020
Institute of Physical Chemistry
2020
Polish Academy of Sciences
2020
According to data from the World Health Organization (WHO), cancer is considered be one of leading causes death worldwide, and new therapeutic approaches, especially improved novel treatment regimens, are in high demand. Considering that many chemotherapeutic drugs tend have poor pharmacokinetic profiles, including rapid clearance limited on-site accumulation, a combined approach with tumor-homing peptide (THP)-functionalized magnetic nanoparticles could lead remarkable improvements. This...
Superparamagnetic iron oxide nanoparticles (SPIONs) and their derivatives (aminosilane gold-coated) have been widely investigated in numerous medical applications, including potential to act as antibacterial drug carriers that may penetrate into bacteria cells biofilm mass. Pseudomonas aeruginosa is a frequent cause of infection hospitalized patients, significant numbers currently isolated clinical strains are resistant standard antibiotic therapy. Here we describe the impact three types...
Synthesis of magnetically separable imidazolinium salts (N-heterocyclic carbene precursor) from amine-terminated magnetic nanoparticles by a direct "grafting from" three-step approach was achieved. Purification after each step the synthesis easily performed using separation products reaction mixtures. Next, were used as ligands in transition-metal complexes. The catalytic properties nanoparticles–Pd complexes Heck cross-coupling tested. In majority tested reactions, catalyst allowed...
Poly(ethylene glycol)–poly(vinylphosphonic acid) double hydrophilic block copolymers were synthesized by RAFT/MADIX polymerization and used to prepare stable iron oxide nanoparticles.
Human plasma gelsolin (pGSN) is a multifunctional actin-binding protein involved in variety of biological processes, including neutralization pro-inflammatory molecules such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA) modulation host inflammatory response. It was found that PBP10, synthetic rhodamine B-conjugated peptide, based on the phosphoinositide-binding site pGSN, exerts bactericidal activity against Gram-positive Gram-negative bacteria, interacts specifically with LPS LTA,...
Colorectal cancer is the fourth most common worldwide and third frequently diagnosed form of associated with high mortality rates. Recently, targeted drug delivery systems have been under increasing attention owing to advantages such as therapeutic effectiveness a significant depletion in adverse events. In this report, we describe biocompatible thermoresponsive FA-conjugated PHEA-b-PNIPAAm copolymers nanocarriers for 5-FU. The block were obtained using RAFT (Reversible...
Abstract The presented research concerns the preparation of polymer nanoparticles (PNPs) for delivery doxorubicin. Several block and statistical copolymers, composed ketoester derivative, N -isopropylacrylamide, cholesterol, were synthesized. In nanoprecipitation process, doxorubicin (DOX) molecules kept in spatial polymeric systems. DOX-loaded PNPs show high efficacy against estrogen-dependent MCF-7 breast cancer cell lines despite low doses DOX applied good compatibility with normal cells....
The mucosal membrane of the oral cavity, due to its unique structure and availability, constitutes an appropriate site for delivery drugs, both with local systemic effects. Mucoadhesive buccal films are drug dosage forms that their convenience application, flexibility size, characterized by patients' compliance. Sodium alginate pectin natural polymers from polysaccharides group, mucoadhesive properties, widely applied obtain films. However, hydrophilic nature poor water resistance limit...
Efficient intracellular delivery of a therapeutic compound is an important feature smart drug systems (SDDS). Modification carrier structure with cell-penetrating ligand, ie, cholesterol moiety, strategy to improve cellular uptake. Cholesterol end-capped poly(N-isopropylacrylamide)s offer promising foundation for the design efficient thermoresponsive systems.A series (PNIPAAm) number-average molar masses ranging from 3200 11000 g·mol-1 were synthesized by reversible addition-fragmentation...
The study presents the synthesis of original cholesterol-terminated copolymers comprising acetylacetone-based (AcacI) and N-isopropylacrylamide (NIPAAm) units with a varied arrangement (block random copolymers). nanoprecipitation method was used to form empty doxorubicin-loaded polymeric nanoparticles (PNPs) from these copolymers, which were further studied in terms their physicochemical biological properties. Unexpectedly, it revealed that even PNPs are effective against breast cancer...
Saliva plays a crucial role in oral cavity. In addition to its buffering and moisturizing properties, saliva fulfills many biofunctional requirements, including antibacterial activity that is essential assure proper microbiota growth. Due numerous extra- intra-systemic factors, there are disorders of secretion, leading dryness. substitutes used such situations must meet demands. This study was design evaluate the effect core-shell magnetic nanoparticles (MNPs) adding (gold-coated...
In this paper, we present two methods of synthesis new bifunctional polymeric nanohybrids, their full characterization and the ability to complex lanthanides ions.
Complexing and easily separable polymer–magnetic nanohybrids based on iron oxide nanoparticles original carbamohydrazonothioate derivatives.
Abstract Background In recent years, targeted drug delivery strategies have received special attention from the scientific world due to advantages such as more effective therapy and reduction of side effects. The principle operation is delayed excretion bloodstream system compared itself, well facilitated penetration into diseased cells thanks use ligands recognized by appropriate receptors. Particularly interesting carriers are amphiphilic copolymers that form nano-sized micelles with a...
Thiolactone-functionalized polyurethanes were produced by using a chain extension method. Isocyanate–telechelic urethane prepolymers of different lengths prepared from two diols and 4,4′-methylenebis(cyclohexyl isocyanate), then reacted with thiolactone-functionalized diols, yielding bearing thiolactone groups either within or along the polymer backbone. Postmodification reactions performed according to an amine–thiol–thiosulfonate conjugation strategy various functional amines...
The possibility of incorporating functional groups into molecular photoswitches is a prerequisite for their versatility and broad-range applications. Herein, we present the first successful synthesis donor–acceptor Stenhouse adducts (DASA) chromophores featuring thiol group. latter provides unique opportunity to investigate photoswitching behavior these visible-light operating on surface metallic nanoparticles. This can be modulated by irradiation time, solvent composition, DASA population,...
Herein is presented fabrication of new efficient antibacterial polymer/gold/magnetic nanohybrids. These nanohybrids consist a superparamagnetic nanoparticle core, which ensures their facile separation, purification and recyclability, polymeric coating exhibits bactericidal activity. They were prepared in an four-step synthetic route involving the following: (1) magnetic nanoparticles by co-precipitation Fe2+ Fe3+ presence ammonia solution; (2) gold shell formation; (3) immobilization...
One of the promising strategies for improvement cancer treatment is application a combination therapy. The aim this study was to investigate anticancer activity nanoformulations containing doxorubicin and iron oxide particles covered with polymeric shells bearing cholesterol moieties. It postulated that due high affinity cell membranes, comprising poly(cholesteryl acrylate) can sensitize cells chemotherapy. performed analyses revealed developed systems are effective against human breast...
In the presented work thermal, theoretical (DFT) and spectroscopic (IR, Raman, NMR) properties of alkali metal complexes with quinolinic acid (2,3-pyridinedicarboxylic acid) dipicolinic (2,6-pyridinedicarboxylic were studied. The IR Raman spectra registered analyzed in range 400–4000 cm−1. 1H NMR 13C compounds have been assigned. electronic charge distribution for studied acids their salts lithium, sodium potassium was calculated. All calculations done frame density functional theory using...