A5002684075- Skin Protection and Aging
- Liver Disease Diagnosis and Treatment
- melanin and skin pigmentation
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Pharmacological Effects of Natural Compounds
- Bee Products Chemical Analysis
- Phytochemical and Pharmacological Studies
- Phytochemicals and Antioxidant Activities
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Berberine and alkaloids research
- Photodynamic Therapy Research Studies
- Phytochemical Studies and Bioactivities
- Bioactive Compounds and Antitumor Agents
- Diet and metabolism studies
- Nanoparticles: synthesis and applications
- Lipid metabolism and biosynthesis
- Phytochemistry Medicinal Plant Applications
- Alcoholism and Thiamine Deficiency
- Circadian rhythm and melatonin
- Prion Diseases and Protein Misfolding
- Drug-Induced Hepatotoxicity and Protection
- Autophagy in Disease and Therapy
Academy of Scientific and Innovative Research
2019-2024
Indian Institute of Integrative Medicine
2019-2024
Council of Scientific and Industrial Research
2021-2024
Chitkara University
2024
Cutaneous pigmentation is an important phenotypic trait whose regulation, despite recent advances, has yet to be completely elucidated. Melanogenesis, a physiological process of melanin production, imperative for organism survival as it provides protection against the environmental insults that majorly involve sunlight-induced skin photodamage. However, immoderate synthesis can cause disorders associated with psychosocial impact. In this study, hypopigmentation effect...
Ultraviolet (UV) exposure to the skin causes photo-damage and acts as primary etiological agent in photo-carcinogenesis. UV-B induces cellular damage is major factor challenging homeostasis. Autophagy allows fundamental adaptation of cells metabolic oxidative stress. Cellular dysfunction has been observed aged tissues toxic insults undergoing Conversely, promising anti-aging strategies aimed at inhibiting mTOR pathway have found significantly improve aging-related disorders. Recently,...
Melanoma, the most serious yet uncommon type of cancer, originates in melanocytes. Risk factors include UV radiation, genetic factors, tanning lamps and beds. Here, we described synthesis selective anti melanoma activity [3,2-b]indole fused 18β-glycyrrhetinic acid, a derivative acid murine B16F10 A375 human cell lines. Among 14 molecules, GPD-12 showed significant cytotoxic against lines with IC50 13.38 μM 15.20 respectively. GPD 12 induced formation reactive oxygen species cells that could...
Chronic exposure to Ultraviolet B radiation (UV-B) evokes a myriad of toxic signalling events in the irradiated skin. One such response is ER stress, which known exacerbate photodamage responses. Also, recent literature has highlighted adverse impact environmental toxicants on mitochondrial dynamics and mitophagy. Impaired escalates oxidative damage causes apoptosis. There have been evidences that support crosstalk between stress dysfunction. However, mechanistic clarification still needed...
Plants with medicinal properties have the ability to provide a variety of herbal medications fewer adverse effects. From literature survey, it has been revealed that Berberis pachyacantha (BP) is being traditionally used for liver diseases. The cytoprotective effect dichloromethane (DCM), ethyl acetate, and n-butanol extracts BP were investigated against ethanol-induced cytotoxicity in HepG2 cells. results ethanol was substantially decreased by DCM, dose-dependent manner. acetate...
Abstract Ultraviolet radiation (UVR) is the major exogenous agent that disturbs tissue homeostasis and hastens onset of age‐related phenotypes (photoaging). Exposure to UV‐B promotes apoptosis in human skin cells via induction Reactive Oxygen Species (ROS)‐mediated Endoplasmic Reticulum (ER) stress by activating PERK‐eIF2α‐CHOP pathway, which plays a role exacerbating photoaging. Alleviating production ROS boosting antioxidant capacity foremost therapeutic strategy avert repercussions...