A5037568293- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Microscopic Colitis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Eosinophilic Esophagitis
- Tuberculosis Research and Epidemiology
- Bacterial Genetics and Biotechnology
- RNA and protein synthesis mechanisms
- Liver Disease and Transplantation
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Porphyrin Metabolism and Disorders
- Celiac Disease Research and Management
- Helicobacter pylori-related gastroenterology studies
- Chronic Lymphocytic Leukemia Research
- Bacteriophages and microbial interactions
- Gastrointestinal Bleeding Diagnosis and Treatment
- Hidradenitis Suppurativa and Treatments
- Neuroendocrine Tumor Research Advances
- Systemic Lupus Erythematosus Research
- Biosimilars and Bioanalytical Methods
- Potassium and Related Disorders
- Polyomavirus and related diseases
AZ Groeninge
2014-2025
AZ Sint-Lucas
2019
KU Leuven
1987-2017
Centre de Biophysique Moléculaire
2013-2015
Centre National de la Recherche Scientifique
2013-2015
Université d'Orléans
2013-2015
Physiologie, Ecologie et Environnement
2013
University College London
1986-1990
The Royal Free Hospital
1986-1990
BACKGROUND AND AIMS It is not known whether lymphocytic colitis and collagenous represent different clinical entities or constitute part of a spectrum disease. METHODS Detailed features histological findings were compared in large series patients with confirmed colitis. RESULTS Histological diagnosis was 96 80 Twenty eight per cent 26% had overlapping but less pronounced features. Both groups equal terms age, use aspirin non-steroidal anti-inflammatory drugs, associated autoimmune...
As real-world data on risankizumab in patients with moderate to severe Crohn's disease (CD) are scarce, we evaluated its effectiveness and safety multirefractory Belgian patients.
RNA-binding protein CsrA is a key regulator of variety cellular processes in bacteria, including carbon and stationary phase metabolism, biofilm formation, quorum sensing, virulence gene expression pathogens. binds to bipartite sequence elements at or near the ribosome loading site messenger RNA (mRNA), most often inhibiting translation initiation. Here we describe an alternative novel mechanism through which achieves negative regulation. We show that binding upstream portion 5' untranslated...
Transcription termination factor Rho is a ring-shaped, ATP-dependent molecular motor that targets hundreds of transcription units in Escherichia coli. Interest was renewed recently on the realization this essential involved multiple interactions and cellular processes protect E. coli genome regulate its expression global scale. Yet it currently unknown if (and how) Rho-dependent mechanisms are conserved throughout bacterial kingdom. Here, we mined public databases to assess distribution,...
OBJECTIVES: Double-blind study comparing efficacy and safety of the topically acting corticosteroid beclomethasone dipropionate (BDP) to prednisone (PD) in patients with active, mild-to-moderate ulcerative colitis (UC). METHODS: Overall, 282 were randomized receive BDP-prolonged release tablets 5 mg once daily for 4 weeks then every other day an additional or oral PD 40 initial 2 tapered 10 during 8-week period. Efficacy end point was non-inferiority BDP vs. terms Disease Activity Index...
Simponi® (golimumab, MSD) is a fully human monoclonal antibody against tumor necrosis factor alpha administered subcutaneously using an autoinjector or prefilled syringe. This study examined preference for administration of golimumab by syringe in patients with moderate-to-severe ulcerative colitis (UC).This was multicenter, open-label, randomized crossover trial (EudraCT no 2014-000656-29). Patients UC were 1:1 to receive 2 subcutaneous injections 50 mg the followed same 4 opposite order....
Acute intermittent porphyria (AIP) is an autosomal dominant disorder of heme biosynthesis due to a mutation in the porphobilinogen deaminase gene. The causes deficiency enzyme, thereby causing accumulation precursors (δ-aminolevulinic acid and porphobilinogen). These neurotoxic elicit acute neurovisceral attacks, which can be treated with heme-arginate infusions. Some patients require infusions on regular basis for many years, ultimately leads iron (increased serum ferritin liver, spleen,...
Recently, concerns were raised of high rates HCC recurrence in patients treated with direct-acting antivirals (DAA) for hepatitis C infection. We investigated the occurrence and within 6 months after treatment DAA or without pegylated interferon (PEG-IFN) real life. This is a retrospective, multicenter cohort trial, executed 15 hospitals distributed across Belgium. Populations matched based on fibrosis score (Metavir F3-F4). Patients Child-Pugh ≥ B excluded. In total, 567 included, whom 77...
The bacterial transcription termination factor Rho-a ring-shaped molecular motor displaying directional, ATP-dependent RNA helicase/translocase activity-is an interesting therapeutic target. Recently, Rho from Mycobacterium tuberculosis (MtbRho) has been proposed to operate by a mechanism uncoupled action, suggesting that the manner used dissociate transcriptional complexes is not conserved throughout kingdom. Here, however, we demonstrate MtbRho bona fide and directional helicase which...
Golimumab (GOL) is registered for moderate to severely active ulcerative colitis (UC). Data on the use of GOL in daily clinical practice are limited. Currently, it unclear which factors predictive a favorable outcome. The goals this study were evaluate mid-term outcome (week 26) patients with severe UC and determine predictors Patients included SMART (NCT02155335) evaluated their Demographic data, disease characteristics, medical history recorded retrospectively. activity based total Mayo...
Summary The ilioinguinal nerve entrapment syndrome is an abdominal muscular pain syndrome, characterized by the clinical triad of type iliac fossa with a characteristic radiation pattern, altered sensory perception in cutaneous innervation area, and well-circumscribed trigger point medial below anterosuperior spine. Relief infiltration local anaesthetic confirms diagnosis. This report describes retrospectively picture 32 mainly non-surgical patients. In 14 cases definite diagnosis was...
Introduction Nationwide studies comparing patients with hepatitis B and C virus (HBV HCV) infections are mandatory for assessing changes in epidemiology. Aim The aim of this study was to compare epidemiological data initial management newly diagnosed persistent HBV (HBsAg positive) or HCV (detectable RNA) infection Belgium. Patients methods Data were extracted from two Belgian observational databases. Results A total 655 (387 268 included. Compared patients, younger, more frequently men,...
The combination therapy of pegylated-interferon-alpha2a plus ribavirin is considered as the standard care for patients with chronic hepatitis C. A sustained viral response obtained in 40-50% naïve genotype 1 and around 80% 2 or 3.To assess whether amantadine, added to conventional therapy, could improve treatment efficacy.In all, 630 (intent-to-treat population) C were randomized into two groups: 316 (treatment group) received (180 microg once weekly) (1000-1200 mg/daily) amantadine (200...
Vascular malformations of the GI tract can be treated by thermal methods, including YAG laser. The diagnosis these lesions is not always easy, and it difficult to evaluate completeness therapy lesions. We investigated value Doppler ultrasound in this respect. TVD-1 (Key Med) transendoscopic vascular detector using 2.5 mm diameter probe emitting at 7 MHz, was used through standard endoscopes. Outputs were monitored a loudspeaker, imaged on an oscilloscope, or recorded mingograph. Diagnostic...