A5026859898- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Neurotransmitter Receptor Influence on Behavior
- Sleep and related disorders
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Neural dynamics and brain function
- Restless Legs Syndrome Research
- Gaze Tracking and Assistive Technology
Montreal Neurological Institute and Hospital
2021-2024
Concordia University
2018-2024
McGill University
2019-2024
Context can influence reactions to environmental cues and this elemental process has implications for substance use disorder. Using an animal model, we show that alcohol-associated context elevates entry into a fluid port triggered by conditioned stimulus (CS) predicted alcohol (CS-triggered alcohol-seeking). This effect persists across multiple sessions and, after it diminishes in extinction, the retains capacity augment reinstatement. Systemically administered eticlopride chemogenetic...
Wheelchairs controlled using electroencephalography (EEG) have been proposed to facilitate independent mobility for people with motor disabilities. To date, the majority of these systems relied on distracting external stimuli such as flashing lights and expensive, medical-grade EEG amplifiers. We propose a wheelchair prototype that uses hand imagery (MI) jaw clench data collected consumer-grade system generate left, right, forward, stop commands. The signal is classified logistic regression,...
Abstract Discrete alcohol cues and contexts are relapse triggers for people with use disorder exerting particularly powerful control over behaviour when they co‐occur. Here, we investigated the neural substrates subserving capacity alcohol‐associated to elevate responding an alcohol‐predictive conditioned stimulus (CS). Specifically, rats were trained in a distinct ‘alcohol context’ respond by entering fluid port during discrete auditory CS that predicted delivery of familiarized ‘neutral...
Background Animal models are critical for studying causal explanations of relapse. Using a Pavlovian conditioning procedure with alcohol, we examined relapse after extinction triggered by either re‐exposure to alcohol (reinstatement) or delay between and test (spontaneous recovery). Methods Male, Long‐Evans rats were acclimated 15% in the home‐cage using an intermittent‐access 2‐bottle choice procedure. Next, they received sessions which auditory‐conditioned stimulus ( CS ; 20 second white...
Sleep is required for successful memory consolidation. spindles, bursts of oscillatory activity occurring during non-rapid eye movement sleep, are known to be crucial this process and, recently, it has been proposed that the temporal organization spindles into clusters might additionally play a role in In Parkinson's disease, spindle reduced, and reduction found predictive cognitive decline. However, remains unknown whether alterations sleep disease sleep-dependent processes such as...
Abstract Sleep is required for successful memory consolidation. spindles, bursts of oscillatory activity occurring during non-REM sleep, are known to be crucial this process and, recently, it has been proposed that the temporal organization spindles into clusters might additionally play a role in In Parkinson’s disease, spindle reduced, and reduction found predictive cognitive decline. However, remains unknown whether alterations sleep disease sleep-dependent processes like consolidation,...
ABSTRACT Patients with Parkinson’s disease, who lose the dopaminergic projections to striatum, are impaired in certain aspects of motor learning. Recent evidence suggests that, addition its role performance, striatum plays a key memory Whether patients have and whether is modulated by dopamine at time initial learning unknown. To address these questions, we measured learned sequence were either On or Off their medications. We compared them group older younger controls. Contrary our...