A5091613414- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Nicotinic Acetylcholine Receptors Study
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Smart Agriculture and AI
- Smoking Behavior and Cessation
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Neurological Disorders and Treatments
- Insect and Pesticide Research
- Mental Health Research Topics
- Renal Transplantation Outcomes and Treatments
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Molecular Communication and Nanonetworks
- Transplantation: Methods and Outcomes
- High Altitude and Hypoxia
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Opioid Use Disorder Treatment
- Anesthesia and Neurotoxicity Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Concordia University
2015-2024
Center for Drug Evaluation and Research
2024
United States Food and Drug Administration
2024
The University of Texas at Austin
2017
University of Maryland, Baltimore
2014
Concordia University Wisconsin
2014
University of Pittsburgh
2001-2011
Ernest Gallo Clinic and Research Center
2007-2009
University of California, San Francisco
2005-2008
Models of intravenous nicotine self-administration in laboratory animals are being used to investigate the behavioral and neurobiological consequences reinforcement, aid development novel pharmacotherapies for smoking cessation. Central these models is principle primary which posits that response-contingent presentation a reinforcer, nicotine, engenders robust operant behavior, whereas response-independent drug delivery does not. This dictum as reinforcer has been widely explain why people...
Addiction is characterized by compulsive alcohol or drug taking and seeking, the dorsal striatum has been implicated in such maladaptive persistent habits. The NMDA receptor (NMDAR), which a major target of alcohol, striatal-based habit learning. We found that, striatum, (ethanol) exposure produced an increase phosphorylation NR2B subunit NMDAR, corresponding activity Fyn kinase, phosphorylates NR2B. further observed ethanol-mediated long-term facilitation (LTF) NR2B-containing NMDARs...
Conditioned behavioral responses to discrete drug-associated cues can be modulated by the environmental context in which those are experienced, a process that may facilitate relapse humans. Rodent models of drug self-administration have been adapted reveal capacity contexts trigger seeking, thereby enabling neurobiological investigations this effect.We tested hypothesis dopamine transmission nucleus accumbens, neural structure mediates reinforcement, is necessary for context-induced...
Abstract Environmental contexts associated with drug use promote craving in humans and drug‐seeking animals. We hypothesized that the basolateral amygdala ( BLA ) itself as well serial connectivity between nucleus accumbens core NAC core) were required for context‐induced renewal of Pavlovian‐conditioned alcohol‐seeking. Male Long‐Evans rats trained to discriminate two conditioned stimuli (CS): a CS+ was paired ethanol (EtOH, 20%, v/v) delivery into fluid port (0.2 mL/CS+, 3.2 mL per...
The reinstatement of ethanol (EtOH)-seeking induced by an EtOH-predictive light-tone stimulus is enhanced in environment associated with prior EtOH self-administration (SA) compared a context unavailability (Tsiang & Janak, 2006). Here we hypothesized that EtOH-seeking would be elicited the conditioned sensory properties and this similarly modulated context. We also determined whether pharmacologically inactivating nucleus accumbens (NAc), key structure relapse circuitry, attenuate...
Environmental stimuli that are reliably paired with alcohol may acquire incentive salience, a property can operate in the use and abuse of alcohol. Here we investigated salience Pavlovian cues using preclinical animal model. Male, Long-Evans rats (Harlan) unrestricted access to food water were acclimated drinking 15% ethanol (v/v) their home-cages. Rats then received autoshaping training which 10 s presentation retractable lever served as conditioned stimulus (CS) unconditioned (US) (0.2...
Context can influence reactions to environmental cues and this elemental process has implications for substance use disorder. Using an animal model, we show that alcohol-associated context elevates entry into a fluid port triggered by conditioned stimulus (CS) predicted alcohol (CS-triggered alcohol-seeking). This effect persists across multiple sessions and, after it diminishes in extinction, the retains capacity augment reinstatement. Systemically administered eticlopride chemogenetic...
Abstract Introduction Drug craving can be independently stimulated by cues that are directly associated with drug intake (discrete cues), as well environmental contexts in which use occurs (contextual cues). We tested the hypothesis context a discrete alcohol‐predictive cue is experienced influence how robustly stimulates alcohol‐seeking behavior. Methods Male, Long‐Evans rats received P avlovian discrimination training ( PDT ) sessions one conditioned stimulus CS +; 16 trials/session) was...
The infralimbic medial prefrontal cortex (IL) is important for suppressing learned behavior after extinction, but whether this function extends to responses acquired through appetitive Pavlovian conditioning unclear. We trained male, Long-Evans rats associate a white-noise conditional stimulus (CS; 10 s; 14 presentations per session) with 10% liquid sucrose (0.2 mL CS presentation), and recorded entries into the fluid port during CS. was presented without in subsequent extinction test...