A5045349822- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Bacterial Genetics and Biotechnology
- Plant Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- RNA and protein synthesis mechanisms
- Antibiotic Resistance in Bacteria
- Viral gastroenteritis research and epidemiology
University of Basel
2021-2025
Bacteriophages, the viruses infecting bacteria, hold great potential for treatment of multidrug-resistant bacterial infections and other applications due to their unparalleled diversity recent breakthroughs in genetic engineering. However, fundamental knowledge molecular mechanisms underlying phage–host interactions is mostly confined a few traditional model systems did not keep pace with massive expansion field. The true biology encoded by these has therefore remained largely untapped,...
Abstract Bacteriophages are ubiquitous viral predators that have primarily been studied using fast-growing laboratory cultures of their bacterial hosts. However, microbial life in nature is mostly a slow- or non-growing, dormant state. Here, we show diverse phages can infect deep-dormant bacteria and suspend replication until the host resuscitates (“hibernation”). newly isolated Pseudomonas aeruginosa phage, named Paride, directly replicate induce lysis While non-growing notoriously tolerant...
Research on bacteriophages, the viruses infecting bacteria, has fueled development of modern molecular biology and inspired their therapeutic application to combat bacterial multidrug resistance. However, most work so far focused a few model phages which impedes direct applications these findings in clinics suggests that vast potential powerful remained untapped. We have therefore recently composed BASEL collection Escherichia coli (BActeriophage SElection for your Laboratory), made relevant...
Abstract Research on bacteriophages, the viruses infecting bacteria, has fueled development of modern molecular biology and inspired their therapeutic application to combat bacterial multidrug resistance. However, most work so far focused a few model phages which impedes direct applications these findings in clinics suggests that vast potential powerful remained untapped. We have therefore recently composed BASEL collection Escherichia coli (BActeriophage SElection for your Laboratory) made...
Summary Bacteriophages are fierce viral predators with no regard for pathogenicity or antibiotic resistance of their bacterial hosts 1,2 . Despite early recognition therapeutic potential and the current escalation multidrug resistance, phages have so far failed to become a regular treatment option in clinical practice 3-5 One reason is occasional discrepancy between poor performance selected vivo despite high potency vitro 3,4,6,7 Similar resilience supposedly drug-sensitive infections has...