A5088357688- Immune Cell Function and Interaction
- Microbial Metabolism and Applications
- Pediatric health and respiratory diseases
- Plant Pathogens and Fungal Diseases
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Enzyme-mediated dye degradation
- Antifungal resistance and susceptibility
- Biocrusts and Microbial Ecology
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- Pneumonia and Respiratory Infections
- Cultural Heritage Materials Analysis
- Analytical Methods in Pharmaceuticals
- Cytokine Signaling Pathways and Interactions
- Cellular transport and secretion
- Bamboo properties and applications
- Infant Nutrition and Health
- Pancreatic function and diabetes
- Escherichia coli research studies
- Lung Cancer Research Studies
- IL-33, ST2, and ILC Pathways
- Fungal Biology and Applications
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
Oregon Health & Science University
2018-2024
VA Portland Health Care System
2019-2020
Oregon State University
2001-2020
Aurora Health Care
2016
Streptococcus pneumoniae is an important bacterial pathogen that causes a range of noninvasive and invasive diseases. The mechanisms underlying variability in the ability S. to transition from nasopharyngeal colonization disease-causing are not well defined. Mucosal-associated invariant T (MAIT) cells prevalent mucosal tissues such as airways believed play role early response infection with pathogens. MAIT recognize contain known. In present study, we analyzed MAIT-cell responses clinical...
Antigen presentation molecules play key roles in activating T cell immunity. Multiple complementary pathways are known to regulate classical MHC-I at transcriptional, translational, and post-translational levels. Intracellular trafficking mechanisms dictating post-transcriptional regulation of MR1, the MHC Class I-like molecule which restricts MAIT cells, have been an area focus; however, little is about MR1 transcriptional regulation. We demonstrate that, similar MHC-I, interferons...
Abstract MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 pathways. To investigate ligand exchange pathways for MR1, we used monomers tetramers loaded with 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU) deliver the antigen. Using MR1-deficient reconstituted wild-type or molecules that cannot bind 5-OP-RU, show of...
Fungal pigments, specifically those generated from spalting fungi, are being developed for broader use in the wood and textile industry, due to their coloration properties, may also be useful as aesthetic bamboo dyes. This paper evaluates potential of fungal pigments (Phyllostachys spp.), compares difference between natural direct application extracted three known fungi: Scytalidium cuboideum, ganodermophthorum, Chlorociboria aeruginosa. Bamboo was significantly spalted by S. cuboideum under...
Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation, increased infiltration by CD8+ T lymphocytes, and infection-driven exacerbations. Although cigarette smoke the leading risk factor for COPD, mechanisms driving development of COPD in only a subset smokers are incompletely understood. Lung-resident mucosal-associated invariant (MAIT) cells play role microbial infections inflammatory diseases. The MAIT pathology unknown. Here, we examined cell activation...
Abstract Mucosal Associated Invariant T (MAIT) cells can sense intracellular infection by a broad array of pathogens. These are activated upon encountering microbial antigen(s) displayed MR1 on the surface an infected cell. Human undergoes alternative splicing. The full-length isoform, MR1A, activate MAIT cells, while function isoforms, MR1B and MR1C, incompletely understood. In this report, we sought to characterize expression these splice variants. Using transcriptomic analysis in...
Plasma concentration time curves following intravenous (i.v.) administration of 1.5 mg/kg ranitidine, 0.2 mg/kg, 0.4 and 0.8 omeprazole, respectively, were analysed in six llamas. profiles after i.v. both drugs showed plasma concentrations declining a biexponential manner with rapid distribution phase. Pharmacokinetics parameters ranitidine to llamas mean elimination half-life 1.53 +/- 0.26 h. The volume (Vdss) was 1.77 0.31 L/kg, body clearance 0.778 0.109 L/kg/h. Ranitidine produced only...
Abstract Mucosal-associated invariant T (MAIT) cells are an innate-like cell subset important in the early response to bacterial and viral lung pathogens. MAIT recognize small molecule metabolites presented on Class I-like MR1. As with other I II molecules, MR1 can likely sample ligands intracellular environment through multiple cellular pathways. Rab6, a GTPase that regulates number of endosomal trafficking pathways including retrograde transport trans-Golgi network (TGN), is involved...
Blastomycosis is an endemic fungal infection. In rural northern Wisconsin, blastomycosis cases are associated with certain environmental features including close proximity to waterways. Other studies have particular soil chemicals. However, also occurs in urban and suburban regions. We explored the geodemographic associations of more urban/suburban landscape eastern Wisconsin.
The use of wood coloured by fungi, or 'spalted' wood, stretches back to the Renaissance. Most this work was restricted shades blue-green, brown, white, and black zone lines. Modern spalting has added in red blue. current colour palette fungi potential be expanded through Scytalidium ganodermophthorum, a fungal pathogen suspected soft rot which produces multiple colours pigment throughout its growth, including yellow purple. However, no previous study tracked extracted across time. This...
Abstract Mucosal Associated Invariant T (MAIT) cells can sense intracellular infection by a broad array of pathogens. These are activated upon encountering microbial antigen(s) displayed MR1 on the surface an infected cell. Human undergoes alternative splicing. The full length isoform, MR1A, activate MAIT cells, while function isoforms, MR1B and MR1C, not well characterized. In this report, we sought to characterize these splice variants. Using transcriptomic analysis in conjunction with...
Abstract Chronic obstructive pulmonary disease (COPD) is associated with airway inflammation, increased infiltration by CD8 + T lymphocytes, and infection-driven exacerbations. COPD most commonly caused cigarette smoke (CS), however the mechanisms driving development of in some smokers but not others are incompletely understood. Lung-resident mucosal-associated invariant (MAIT) cells play a role both microbial infections inflammatory diseases. MAIT cell frequency reduced peripheral blood...
Abstract MAIT cells, a highly prevalent subset of T cells restricted by the MHC Class I-like molecule MR1, play key role in early response to bacterial infection. Chronic obstructive pulmonary disease (COPD) pathogenesis is associated with airway inflammation, increased infiltration CD8+ lymphocytes, and infection-driven exacerbations. Cigarette smoke (CS), leading cause COPD, leads impaired immune function epithelial (AECs) decreases surface expression classical I molecules. However, impact...
Abstract MR1-restricted T cells have been implicated in microbial infections, sterile inflammation, wound healing and cancer. Similar to other antigen presentation molecules, evidence supports multiple, complementary MR1 pathways. To investigate ligand exchange pathways for MR1, we used monomers tetramers loaded with 5-(2-oxopropylideneamino)-6-d-ribitylaminouracil (5-OP-RU) deliver the antigen. Using MR1-deficient reconstituted wild-type or molecules that cannot bind 5-OP-RU, show of...