A5041077530- Adenosine and Purinergic Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Neurological Complications and Syndromes
- Cell Adhesion Molecules Research
- Nerve injury and regeneration
- Multiple Sclerosis Research Studies
- Nicotinic Acetylcholine Receptors Study
- Atherosclerosis and Cardiovascular Diseases
- Cytomegalovirus and herpesvirus research
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Neonatal Respiratory Health Research
- Ion Channels and Receptors
- Sulfur Compounds in Biology
- Pancreatic function and diabetes
- Signaling Pathways in Disease
- Maternal Mental Health During Pregnancy and Postpartum
- Fatty Acid Research and Health
- Genetics and Neurodevelopmental Disorders
- Pregnancy and Medication Impact
- Prenatal Substance Exposure Effects
- Neurological Disorders and Treatments
- Cardiac electrophysiology and arrhythmias
- Moyamoya disease diagnosis and treatment
University of Belgrade
2015-2024
Neurodegeneration implies progressive neuronal loss and neuroinflammation further contributing to pathology progression. It is a feature of many neurological disorders, most common being Alzheimer's disease (AD). Repetitive transcranial magnetic stimulation (rTMS) non-invasive which modulates excitability stimulated brain areas through pulses. Numerous studies indicated beneficial effect rTMS in several diseases, including AD, however, exact mechanism are yet be elucidated. We aimed evaluate...
CD73 is a bifunctional glycosylphosphatidylinositol (GPI)-anchored membrane protein which functions as ecto-5′-nucleotidase and receptor for extracellular matrix (ECM). A large body of evidence demonstrates critical involvement altered purine metabolism particularly, increased expression in number human disorders, including cancer immunodeficiency. Massive up-regulation was also found reactive astrocytes several experimental models neuropathologies. In all the pathological contexts studied...
It is widely accepted that adenosine triphosphate (ATP) acts as a universal danger‐associated molecular pattern with several known mechanisms for immune cell activation. In the central nervous system, ATP activates microglia and astrocytes induces neuroinflammatory response. The aim of present study was to describe responses isolated increasing concentrations (5 µM 1 mM), which were intended mimic graded intensity extracellular stimulus. results show activation response in terms...
The present study examined the involvement of purinergic signaling components in rat model hippocampal degeneration induced by trimethyltin (TMT) intoxication (8 mg/kg, single intraperitoneal injection), which results behavioral and neurological dysfunction similar to neurodegenerative disorders. We investigated spatial temporal patterns ecto-nucleoside triphosphate diphosphohydrolase 1 (NTPDase1/CD39) ecto-5' nucleotidase (eN/CD73) activity, their cell-specific localization, analyzed gene...
Multiple sclerosis (MS) is a chronic neurodegenerative disease caused by autoimmune-mediated inflammation in the central nervous system. Purinergic signaling critically involved MS-associated neuroinflammation and its most widely applied animal model—experimental autoimmune encephalomyelitis (EAE). A promising but poorly understood approach treatment of MS repetitive transcranial magnetic stimulation. In present study, we aimed to investigate effect continuous theta-burst stimulation (CTBS),...
Abstract Ecto‐5′‐nucleotidase/CD73 (eN/CD73) is a membrane‐bound enzyme involved in extracellular production of adenosine and cell adhesion molecule cell–cell interactions. In neuroinflammatory conditions such as experimental autoimmune encephalomyelitis (EAE), reactive astrocytes occupying active demyelination areas significantly upregulate eN/CD73 express additional variants. The present study investigated whether the different variants represent distinct glycoforms functional consequences...
Extracellular matrix glycoprotein tenascin-C (TnC) is highly expressed in vertebrates during embryonic development and thereafter transiently tissue niches undergoing extensive remodeling regeneration after injury. TnC’s different functions can be attributed to its multimodular structure represented by distinct domains alternatively spliced isoforms. Upon central nervous system injury, TnC upregulated secreted into the extracellular mainly astrocytes. The goal of present study was elucidate...
Ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2) hydrolyzes extracellular ATP to ADP, which is the ligand for P2Y 1,12,13 receptors. The present study describes distribution of NTPDase2 in adult rat brains physiological conditions, and hippocampal neurodegeneration induced by trimethyltin (TMT). also regulation inflammatory mediators primary astrocytes oligodendroglial cell line OLN93. In protein was most abundant hippocampus, where it found fibrous synaptic endings synaptic-rich...
Exposure to the neurotoxin trimethyltin (TMT) selectively induces hippocampal neuronal injury and astrocyte activation accompanied with resultant neuroinflammation, which causes severe behavioral, cognitive, memory impairment. A large body of evidence suggests that flaxseed oil (FSO), as one richest sources essential omega-3 fatty acids, i.e., α-linolenic acids (ALA), displays neuroprotective properties. Here, we report preventive effects dietary FSO treatment in a rat model TMT...
Abstract BackgroundThe present study aims to explore the involvement of purinergic signaling in rodent model hippocampal degeneration induced by trimethyltin (TMT), which results behavioral and neurological dysfunction similar Alzheimer’s disease. Our has provided novel evidence that TMT extracellular depositions amyloid β, might be cause well-defined progressive neurodegeneration gliosis. MethodsWe have applied enzyme histochemistry immunohistochemistry spatial temporal patterns...
Understanding processes that occur after injuries to the central nervous system is essential in order gain insight into how restoration of function can be improved. Extracellular glycoprotein tenascin-C (TnC) has numerous functions wound healing process depending on expression time, location, isoform and binding partners which makes it interesting study this context. We used an vitro injury model, mixed culture cortical astrocytes microglia, observed without TnC microglial cells tend...