A5051238542- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- Ion channel regulation and function
- Peroxisome Proliferator-Activated Receptors
- Infant Nutrition and Health
- COVID-19 and Mental Health
- Axon Guidance and Neuronal Signaling
- Breastfeeding Practices and Influences
- Sphingolipid Metabolism and Signaling
- Lipid metabolism and biosynthesis
- Diet and metabolism studies
- COVID-19 Digital Contact Tracing
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Lipid Membrane Structure and Behavior
- Innovative Human-Technology Interaction
- COVID-19 epidemiological studies
- Cholinesterase and Neurodegenerative Diseases
- Innovative Approaches in Technology and Social Development
- Calcium signaling and nucleotide metabolism
- Cancer Research and Treatment
- Proteoglycans and glycosaminoglycans research
- Mobile Health and mHealth Applications
- Tissue Engineering and Regenerative Medicine
- Surgical Simulation and Training
Universidad Autónoma de Madrid
2011-2022
Altera (United States)
1978-2020
Universidad Carlos III de Madrid
2020
Hospital Universitario de La Princesa
2011-2013
Exclusive breastfeeding is recommended for the first six months of life to promote adequate infant growth and development, reduce morbidity mortality. However, whenever some mothers are not able breastfeed their infants, formulas mimicking human milk needed, safety efficacy each formula should be tested. Here, we report results a multicenter, randomized, blinded, controlled clinical trial that aimed evaluate novel starting on weight gain body composition infants up 6 12 months, as well...
Pediatric obesity has a growing health and socio-economical impact due to cardiovascular metabolic complications in adult life. Some recent studies suggest that live or heat-treated probiotics have beneficial effects preventing fat deposition preclinical clinical sets. Here, we explored the of probiotic Bifidobacterium animalis subsp. lactis CECT 8145 (HT-BPL1), added as supplement on an infant milk formula (HT-BPL1-IN), Caenorhabditis elegans short-chain fatty acids (SCFAs) lactate, using...
Topographical and biochemical characteristics of the substrate are critical for neuronal differentiation including axonal outgrowth regeneration neural circuits in vivo. Contact stimuli signaling molecules allow neurons to develop stabilize synaptic contacts. Here we present development, characterization functional validation a new polymeric support able induce both PC12 cell line adult primary skin-derived precursor cells vitro. By combining photolithographic technique with use...
Hospital workers have been the most frequently and severely affected professional group during COVID-19 pandemic, a big impact on transmission. In this context, innovative tools are required to measure symptoms compatible with COVID-19, spread of infection, testing capabilities within hospitals in real time.We aimed develop test an effective user-friendly tool identify track hospital workers.We developed pilot tested Epidemics Tracker (HEpiTracker), newly designed app among workers. staff 9...
Chondroitin sulfate (CS) proteoglycans (CSPGs) are the most abundant PGs of brain extracellular matrix (ECM). Free CS could be released during ECM degradation and exert physiological functions; thus, we aimed to investigate effects on voltage- current-clamped rat embryo hippocampal neurons in primary cultures. We found that elicited a whole-cell Na(+)-dependent inward current (ICS) produced drastic cell depolarization, cytosolic calcium transient ([Ca(2+)]c). Those were similar those by...
Altered synaptic transmission with excess glutamate release has been implicated in the loss of motoneurons occurring amyotrophic lateral sclerosis (ALS). Hyperexcitability or hypoexcitability from mice carrying ALS mutation SOD1(G93A) (mSOD1) also reported. Here we have investigated excitability, ion currents, and kinetics exocytotic fusion pore chromaffin cells postnatal day 90 to 130 mSOD1 mice, when motor deficits are already established. With respect wild-type (WT), had a decrease...
The ability to recreate an optimal cellular microenvironment is critical understand neuronal behavior and functionality in vitro. An organized neural extracellular matrix (nECM) promotes cell adhesion, proliferation differentiation. Here, we expanded previous observations on the of nECM support vitro differentiation, with following goals: (i) complex networks embryonic rat hippocampal cells, (ii) achieve improved levels dopaminergic differentiation subventricular zone (SVZ) progenitor cells....
Hippocampal gamma oscillation, involved in cognitive processes, can be induced by muscarinic acetylcholine receptors activation and depends large part on the of γ-aminobutyric acidergic (GABAergic) interneurons. The precise role modulatory action GABAergic transmission still remains unclear due to great heterogeneity observed effects. We have examined presynaptic postsynaptic mechanisms involved. Methacholine induces a down-regulation evoked inhibitory currents (eIPSCs) not associated with...
Skeletal muscle can be engineered by converting dermal precursors into progenitors and differentiated myocytes. However, the efficiency of development remains relatively low it is currently unclear if this due to poor characterization myogenic precursors, protocols used for cell differentiation, or a combination both. In study, we characterized present in murine dermospheres, evaluated mature myotubes grown novel three-dimensional culture system. After 5-7 days observed isolated, twitching...
Head Up Displays (HUDs) were designed originally to present at the usual viewpoints of pilot main sensor data during aircraft missions, because placing instrument information in forward field view enhances pilots ability utilize both and environmental simultaneously. The first civilian motor vehicle had a monochrome HUD that was released 1988 by General Motors as technological improvement HeadDown Display (HDD) interface, which is commonly used automobile industry. reduces number duration...
Neuropathic pain (NP) is a challenging condition to treat, as the need for new drugs treat NP an unmet goal. We investigated analgesic potential of sulfated disaccharide compound, named BIS014. Oral administration (p.o.) this compound induced ameliorative effects in formalin-induced nociception and capsaicin-induced secondary mechanical hypersensitivity mice, but also after partial sciatic nerve transection (spared injury), chemotherapy (paclitaxel)-induced NP, diabetic neuropathy by...
Abstract Background Breastmilk is the ideal food for infants and exclusive breastfeeding recommended. In clinical trial aimed to evaluate a new starting formula on weight gain of up 6 12 months. The novel was compared with standard breastfeeding, latter being used as reference method. Methods 210 (70/group) were enrolled in study, completed intervention until months age. For period, divided into three groups: group 1 received (Nutribén Innova®1 or INN), lower amount protein, enriched...
In search of druggable synthetic lipids that function as potential modulators synaptic transmission and plasticity, we synthesized sulfoglycolipid IG20, which stimulates neuritic outgrowth. Here, have explored its effects on ion channels exocytosis in bovine chromaffin cells. IG20 augmented the rate basal catecholamine release. Such effect did not depend Ca(2+) mobilization from intracellular stores; rather, IG20-elicited secretion entirely dependent entry through L-subtype voltage-activated...