The objective of this study was to estimate the US societal economic burden schizophrenia and update 2002 reported costs $62.7 billion given disease management health care structural changes last decade.A prevalence-based approach used assess direct costs, non-health indirect associated with (ICD-9 codes 295.xx) for 2013, cost adjustments where necessary. Direct were estimated using a retrospective matched cohort design Truven Health Analytics MarketScan Commercial Claims Encounters,...

Background Agitation is a common neuropsychiatric symptom of Alzheimer disease (AD). Data are scarce regarding agitation prevalence among community‐dwelling patients with AD. Objective To estimate in sample US AD/dementia overall and by severity, using data from electronic health records (EHR). Methods This retrospective database study examined ≥1 EHR record indicating January 2008 to June 2015 no evidence non‐Alzheimer dementia during the 12‐month preindex postindex periods. was identified...

Alzheimer's disease or dementia can impose a significant burden on family and other informal caregivers. This study investigated how the inclusion of family/informal caregiver spillover effects in cost-utility analysis may influence reported value disease/dementia interventions. We used PubMed to identify analyses published from 1 January, 2000 31 March, 2018. reviewed abstracted information each using two-reader consensus process. frequency methods which family/caregiver costs health were...

Although patients with dementia frequently experience neuropsychological symptoms (NPS) such as agitation, which profoundly impacts patients, caregivers, and the healthcare system, few studies have evaluated associated burden of agitation or agitation-related in dementia.This retrospective analysis claims data from Truven Health MarketScan® database (2012-2015) compared clinical characteristics, treatment patterns, resource utilization, costs among behavioral disturbances (BD) versus without...

Abstract Background Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common inherited diseases characterized by progressive development renal cysts and numerous extra-renal manifestations, eventually leading to failure. Given its chronic nature, ADPKD expected carry a substantial economic burden over course disease. However, there paucity evidence on impact from societal perspective. This study aimed estimate direct indirect costs associated with in United States (US)....

Background: At least 90%of patients with dementia experience behavioral or neuropsychiatric symptoms including agitation, psychotic symptoms, apathy, depression, and sleep disturbances. Agitation has been reported to be experienced by 60%of mild cognitive impairment 76%of Alzheimer’s disease. Objective: We aimed assess the impact of agitation in on healthcare resource utilization (HCRU) costs. Methods: This was a retrospective analysis physician-reported patient data from point-in-time...

Dementia is a prevalent condition in older adults associated with decline cognitive and functional abilities substantial burden. This study assessed the prevalence impact of subjective memory impairment United States.The 2011 to 2014 National Health Nutrition Examination Survey, population-based, nationally representative survey, was analyzed. Data included medical examinations, self-reported limitations, health care utilization over 1 year. Participants were aged ≥65 years completed both...

To describe characteristics and compare clinical outcomes including falls, fractures, infections, neuropsychiatric symptoms (NPS) among long-term care residents with dementia without agitation.A cross-sectional secondary analysis of administrative healthcare data was conducted whereby residing in a facility for ≥12 months were identified from the AnalytiCare LLC database (10/2010-06/2014) classified into mutually exclusive cohorts (Agitation Cohort or No-Agitation Cohort) based on available...

Alzheimer's disease (AD) is the most common neurodegenerative form of dementia. Pharmacological therapies for symptomatic treatment, such as acetylcholinesterase inhibitors (AChEIs) and memantine, have been available in USA since 2000. Over past decade, few studies analyzed real-world anti-dementia treatment patterns USA. This study evaluated monotherapy AChEIs memantine among newly diagnosed AD patients. A retrospective cohort was conducted using Medicare data Minimum Data Set from 2008 to...

Agitation in individuals with Alzheimer's disease (AD) may predict institutionalization. This study assessed the incremental risk and costs associated agitation AD.A retrospective analysis of National Coordinating Center Uniform Data Set (June 2005-February 2018) was conducted. Incremental institutionalization estimated used number institutionalized AD living by residential setting United States (literature-based), to estimate costs.The included 11,348 AD: 6603 (58.2%) 4745 (41.8%) without...

Chronic kidney disease (CKD) has a far-reaching impact on both patients and care partners, which can be further compounded by frequent complications such as anemia. This study assessed the burden experienced with CKD partners of CKD, without anemia.Online survey.Adult adult living in United States were recruited through American Association Kidney Patients third-party online panel (January 9, 2020-March 12, 2020).Patient partner characteristics, received or provided; health-related quality...

Objective: This study used a decision-analytic framework to assess the cost-effectiveness of brexpiprazole vs comparator branded therapies for reducing relapses and hospitalizations among adults with schizophrenia from US payer perspective. Methods: An economic model was developed patients stable initiating treatment (1–4 mg), cariprazine (1–6 or lurasidone (40–80 mg) over 1-year period. After 6 months, remained on discontinued due relapse, adverse events, other reasons. Patients who relapse...

Few studies have examined patient characteristics and treatment patterns among patients with dementia agitation in the United States (US). To examine real-world of related to who were treated antipsychotics US residential care community-based settings. This retrospective chart review collected physician-level data from 55 90 years old initiated on an antipsychotic medication for January 2018 May 2018. Clinical assessed overall stratified by A total 313 participating physicians, 59.5% whom...

Background: In people with dementia, neuropsychiatric symptoms (NPSs), especially agitation, are associated worse quality of life and caregiver burden. As NPSs may vary illness severity, knowledge how dementia their caregivers describe rate the importance agitation can improve understanding clinical meaningfulness manifestations agitation. The internet provides new opportunities to better understand patient experiences, as patients increasingly look Web-based platforms a means managing...

Major depressive disorder (MDD) is a debilitating psychiatric illness with high cost burden. This analysis evaluates the cost-effectiveness of adjunctive brexpiprazole versus comparator branded treatment for MDD and background antidepressant therapy (ADT) alone from US payer perspective.An economic model was developed to assess ADT on total direct medical costs using 6-week cycle time frame 48 weeks, response remission as primary outcomes. The consisted 3 parts, 1 represent acute phase 2...

To evaluate geographic variation in the prevalence of autosomal dominant polycystic kidney disease (ADPKD) US, including ADPKD at risk rapid progression.Claims data from IBM MarketScan Commercial and Medicare Supplemental databases (01/16/2016-12/31/2017) were used to estimate 2017 annual 2016-2017 two-year diagnosed progression US overall, stratified by census regions states. Risk was identified based on either: hypertension <35 years, hematuria <30 albuminuria, stage 2 chronic (CKD) 3 CKD...

Autosomal dominant polycystic kidney disease (ADPKD) is a rare inherited disorder with considerable symptom burden and negative effects even in early-stage disease. Patients' reporting of ADPKD may differ from physicians' impressions. In this quantitative, cross-section survey study, we evaluated patient physician assessments at early- late-stage ADPKD.In the United States, 300 patients 155 physicians treating completed online surveys administered by Kantar. Disease stage was categorized as...

Abstract Background Despite a wide range of available treatments, there is limited evidence as to why significant numbers Crohn’s disease (CD) patients do not achieve remission or continue have residual symptom burden. We aimed quantify the impact this suboptimal treatment on patient incidence and severity, quality life (QoL), work impairment. Methods Data were derived from Adelphi Real World CD Disease Specific Programme, cross-sectional survey their treating physicians in France, Germany,...

Progression of autosomal dominant polycystic kidney disease (ADPKD) is highly variable, with some patients progressing rapidly to end-stage renal (ESRD). Abdominal imaging an important modality for verifying diagnosis in at risk ADPKD, targeting them early treatment that could slow onset ESRD. Published literature limited on the real-world abdominal utilization patterns ADPKD.A retrospective healthcare administrative claims analysis examining scans occurring from January 1, 2014, through...

Dementia and Alzheimer's disease (AD) can exact a significant financial, physical emotional toll on family members caregivers. Failing to incorporate these “spillover effects” in AD economic evaluations may underestimate the value of health care intervention. We reviewed current practices literature investigated how spillover effects influence cost-effectiveness interventions. analyzed cost-utility analyses (CUAs) related or dementia published from 2000–2016 using PubMed Tufts...

Behavioral and neuropsychiatric symptoms including agitation, aggression sleep disturbances, are a common potentially severe problem complicating dementia. Relatively few data on type frequency of behavioral disturbances (BD) experienced by patients published. This study describes the prevalence, frequency, types BD in with dementia United States. We analyzed patient charts extracted treating clinicians from Adelphi Dementia Disease Specific Program collected Q1 2016. Eligible were ≥50...

Evaluation of dependence has been suggested as a potential method for translating the effect changes in cognition, function, and behavior into more holistic description AD progression. This review evaluates existing literature regarding overall concept dependence, its measurement, relationship with longitudinal outcomes. A systematic peer-reviewed articles published between January 1995 October 2015 was performed using MEDLINE, EMBASE, Cochrane Central Library Controlled Trials. Randomized...