Lymphovascular invasion (LVI) is an important prognostic factor in patients with lymph node-negative invasive breast cancer. However, the value of LVI it unclear and controversial about its node-positive cancer patients. So, we report analysis significance a large cohort study cancer.We retrospectively reviewed 967 that had undergone surgical treatment at our hospital, from January 2004 to December 2007. Among these thempatients, 349 are were included this study. We evaluated clinical...

Summary Woody biomass has gained popularity as an environmentally friendly, renewable and sustainable resource for liquid fuel production. Here, we demonstrate biotechnological improvement of the quantity quality woody by employing developing xylem ( DX )‐preferential production gibberellin GA ), a phytohormone that positively regulates stem growth. First, proof concept experiment, produced transgenic Arabidopsis plants expressing 20‐oxidase, key enzyme in bioactive s, from Pinus densiflora...

ACADEMIC EMERGENCY MEDICINE 2011; 18:597–604 © 2011 by the Society for Academic Emergency Medicine Objectives: The objective was to compare predictive performance of three previously derived cranial computed tomography (CT) rules, Canadian CT Head Rule (CCHR), New Orleans Criteria (NOC), and National X-Ray Utilization Study (NEXUS)-II, detecting clinically important traumatic brain injury (TBI) need neurosurgical intervention in patients with blunt head trauma. Methods: This a prospective,...

Anthocyanins are a group of colorful and bioactive natural pigments with important physiological ecological functions in plants. We found an MYB transcription factor (PtrMYB119) from Populus trichocarpa that positively regulates anthocyanin production when expressed under the control CaMV 35S promoter transgenic Arabidopsis Amino acid sequence analysis revealed PtrMYB119 is highly homologous to PAP1 (PRODUCTION OF ANTHOCYANIN PIGMENT1), well-known transcriptional activator biosynthesis....

Higher thyroid-stimulating hormone (TSH) levels are associated with differentiated thyroid cancers (DTC). To validate this association, we compared TSH obtained from euthyroid patients DTC controls in the general population.The case group included 1759 DTC, who underwent surgery at Chonnam National University Hwasun Hospital. The control (n = 1548), had participated Thyroid Disease Prevalence Study were used as a healthy group. subjects divided into four groups of similar size according to...

Lymphovascular invasion (LVI) has been a predictor of worse survival outcomes in breast cancer. However, the role LVI compared than pathologic complete response (pCR) following neoadjuvant chemotherapy (NAC) remains unclear. The aim this study was to examine association between and clinicopathological features patients with cancer treated NAC. We retrospectively analyzed 187 NAC surgery 2005 2013 our institution. Kaplan–Meier analyses were used assess recurrence-free (RFS) overall (OS)....

With the exponential growth of human population and industrial developments, research on renewable energy resources is required to alleviate environmental economic impacts caused by consumption fossil fuels. In this study, we present a synthetic biological application wood forming tissue-specific bicistronic gene expression system improve both quantity quality woody biomass minimize undesirable penalties. Our transgenic poplars, designed express PdGA20ox1 (a GA20-oxidase from Pinus...

We evaluated the capability of neutrophil to lymphocyte ratio (NLR) as a diagnostic tool discriminate between poorly differentiated thyroid cancer (PDTC) and anaplastic (ATC) from well (WDTC).The NLR 3,870 patients with benign malignant tumors were analyzed. There 436 benign, 3,364 papillary, 15 medullary, 34 follicular or hurthle type, 14 PDTC, 7 ATC type neoplasms. Patients divided into two groups: high group low group.The all was normal distribution, median value 1.57. Advanced stage...

Both anthocyanins and lignins are essential secondary metabolites in plant growth development. Their biosynthesis is metabolically interconnected diverges the central metabolite 4-coumaroyl CoA of phenylpropanoid pathway. Considerable progress has been made understanding transcriptional regulation genes involved lignin anthocyanin synthesis pathways, but concerted these pathways not yet fully understood. Here, we functionally characterized PtrMYB120, a R2R3-MYB transcription factor from...

Objective We aimed to investigate the effect of crowding on hospital mortality pediatric patients from adult-pediatric mixed emergency departments (EDs). Methods used National Emergency Department Information System database, which included demographic, clinical, diagnostic, and procedural information with all visiting 116 EDs Korea since 2004. enrolled mean length stay more than 6 hours. Study period was January 2006 December 2008. Pediatric younger 15 years admitted these were study...

Purpose:We investigated the prognosis according to age in papillary thyroid carcinoma (PTC) patients.Methods: We retrospectively evaluated 2,890 patients who underwent thyroidectomy due PTC between May 2004 and Aug 2008.We divided into 3 groups: young (≤35 years old), middle (between 35 54 old (≥55 old).Results: Median was 47.0 (range, 15 82 years).Within a follow-up period median of 50 months, there were 148 (5.1%) locoregional recurrences, 6 (0.2%) PTC-related deaths, 18...

Gibberellins (GAs) are important regulators of plant shoot biomass growth, and GA 20-oxidase (GA20ox) is one the major regulatory enzymes in biosynthetic pathway. Previously, we showed that expression levels a putative GA20ox1 (i.e., PdGA20ox1) stem tissue 3-month-old seedlings 12 families Pinus densiflora were positively correlated with diameter growth across those same growing an even-aged 32-year-old pine forest (Park EJ, Lee WY, Kurepin LV, Zhang R, Janzen L, Pharis RP (2015) Plant...

Background/Aim: The inhibition of a disintegrin and metalloproteinase (ADAM) has the potential to become novel approach for natural killer (NK) cell-based cancer immunotherapy. Thus, aim this study was investigate influence ADAM10 ADAM17 inhibitors on expanded NK cell enhance antibody-dependent cellular cytotoxicity (ADCC) in breast lines. Materials Methods: cells were medium supplemented with an or inhibitor prevent shedding soluble CD16/FcγRIII. expression level CD16 production...

This study was performed to analyze the surgical pathology results of "atypia undetermined significance" (AUS) category from thyroid fine needle aspiration (FNA) and describe characteristics distinguish a malignant benign nodule.A retrospective analysis done on 116 patients who underwent surgery December 2008 2012, following diagnosis AUS preoperative FNA. We investigated age, gender, size site nodules, ultrasonographic criteria, cytological features, number atypia after repeated FNAs,...

Wood, the most abundant biomass on Earth, is composed of secondary xylem differentiated from vascular cambium. However, underlying molecular mechanisms wood formation remain largely unclear. To gain insight into formation, we performed a series wood-forming tissue-specific transcriptome analyses hybrid poplar (Populus alba × P. glandulosa, clone BH) using RNA-seq. Together with shoot apex and leaf tissue, cambium tissues were isolated vertical stem segments representing gradient growth...

Drought stress is one of the major environmental problems in growth crops and woody perennials, but it getting worse due to global climate crisis. XERICO, a RING (Really Interesting New Gene) zinc-finger E3 ubiquitin ligase, has been shown be positive regulator drought tolerance plants through control abscisic acid (ABA) homeostasis. We characterized poplar (Populus trichocarpa) protein family identified closest homolog XERICO called PtXERICO. Expression PtXERICO induced by both salt stress,...

Papillary thyroid cancer (PTC) patients with ipsilateral neck metastatic lymph node (LN) and those contralateral LN belong to N1b. Only a few studies have reported on comparisons regard laterality of lateral LN. The aim this study was evaluate predictive factors for metastasis determine prognostic recurrence in PTC N1b.This retrospective reviewed the medical records 390 who underwent total thyroidectomy central dissection plus or bilateral modified radical (MRND) between January 2004...

Although conifers have significant ecological and economic value, information on transcriptional regulation of wood formation in is still limited. Here, to gain insight into secondary cell wall (SCW) biosynthesis tracheid conifers, we performed tissue-specific transcriptome analyses Pinus densiflora (Korean red pine) using RNA sequencing. In addition, obtain full-length information, PacBio single molecule real-time iso-sequencing was carried out RNAs from 28 tissues P. densiflora. Subsequent...

We investigated the incidence and risk factors of hypothyroidism after thyroid lobectomy, evaluated possibility to predict preoperatively with serologic markers, such as thyrotropin (TSH), thyroglobulin (TG), anti-thyroglobulin (ATA), anti-microsomal antibody (AMA).We enrolled 123 consecutive patients who underwent lobectomy due benign conditions between May 2004 April 2008. Only preoperative euthyroid were included. Patients divided into two groups by postoperative function outcomes,...

Introduction Several studies have reported a high frequency of papillary thyroid cancer (PTC) in patients with acromegaly. The aim this study was to determine the prevalence and predictors acromegaly investigate BRAFV600E mutation PTC without Materials Methods We conducted retrospective 60 Thyroid ultrasonography (US) US-guided fine needle aspiration were performed on nodules sonographic features malignancy. selected 16 non-acromegalic as control group. analyzed paraffin-embedded surgical...

A phenotype-based screening of the T1 transgenic Arabidopsis population transformed by overexpression constructs entire poplar MYB transcription factor family found that a factor, PtrMYB012, in resulted upwardly curled rosette leaves, dwarfism and male sterility. Sequence analysis identified PtrMYB012 is homologous to GAMYB genes (e.g., AtMYB65 AtMYB33). Gene expression revealed specifically expressed floral tissues, especially catkins, similar AtMYB65. It was well known GAMYBs are...

The effectiveness of using serum thyroglobulin (TG) to predict thyroid cancer recurrence after a lobectomy is unknown. This study aimed evaluate the predictive nature TG and trends lobectomies.We analyzed 514 papillary (PTC) patients. pre-, low-, high, last-TG levels were reviewed stratified into three groups. An ascending trend was defined if level more than 200% as high value low-TG level. A descending decreased by 50% flat between them.During median follow-up period 73.0 months, there 21...