A5013269146- Cervical Cancer and HPV Research
- Retinal and Macular Surgery
- Glaucoma and retinal disorders
- Intraocular Surgery and Lenses
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Ocular Oncology and Treatments
- Corneal Surgery and Treatments
- Genital Health and Disease
- Corneal surgery and disorders
- Hepatitis B Virus Studies
- Muscle Physiology and Disorders
- Endometrial and Cervical Cancer Treatments
- Cerebral Venous Sinus Thrombosis
- Sustainable Finance and Green Bonds
- Diagnosis and treatment of tuberculosis
- Telomeres, Telomerase, and Senescence
- Pregnancy and Medication Impact
- vaccines and immunoinformatics approaches
- Nuclear Structure and Function
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Retinoids in leukemia and cellular processes
- Mitochondrial Function and Pathology
All India Institute of Medical Sciences
2009-2022
Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital
2018-2019
Post Graduate Institute of Medical Education and Research
2018-2019
Birmingham and Midland Eye Centre
2018
All India Institute of Medical Sciences Bhopal
2016
Vision Eye Institute
2016
Human papilloma virus is a causative factor in the etiology of cervical cancer with HPV16 being most prevalent genotype associated it. Intratype variations oncogenic E6/E7 and capsid L1 proteins HPV 16 besides phylogenetic importance, are risk viral persistence progression. The objective this multicentric study was to identify HPV-16 E6, E7 variants India their possible biological effects. Squamous cell biopsies were collected from 6 centres examined for presence 16. Variants characterized...
Hypothesis: Assessment of the prevalence and type distribution human papillomavirus (HPV) in squamous cell carcinomas (SCC) cervix across India was undertaken to estimate impact available prophylactic HPV-L1 vaccines country find out additional types that might be needed incorporated second-generation vaccines. Methods: High-risk (HR) HPVs were genotyped from 667 histopathologically confirmed cases SCC 6 different centers representing 4 regions India: Advanced Centre for Treatment, Research...
To evaluate the outcomes of single pass thin lenticule sutureless Descemet's stripping automated endothelial keratoplasty with donor lenticules prepared using a 400 μm microkeratome head.Interventional case series.Cases corneal dysfunction.Fifteen cases dysfunction (eight pseudophakic bullous keratopathy, three Fuchs' dystrophy, congenital hereditary dystrophy and one failed graft) underwent at tertiary care hospital. Donor was Carriazo Barraquer (Moria, Antony, France) head. Sutureless...
Abstract. Telomerase-A molecular marker for cervical cancer screening. Cervical is one of the most common cancers in women and can be routinely screened by Papanicolaou smear. Screening HPV high-risk types 16 18 has augmented sensitivity this test, but still some cases remain undetected. We have investigated utility assaying telomerase activity as a possible screening cancer. Telomerase was studied relation to 16/18 infection, smear cytopathology, biopsy histopathology total 88 subjects,...
<i>Objective:</i> The aim of this study was to examine the expression apoptosis-related proteins in cervical cancer, and investigate their correlation with apoptotic index (AI), telomerase activity, human papilloma virus (HPV) infection clinicopathological characteristics. <i>Methods:</i> Fifty cancer samples 20 normal tissues were assessed for protein survivin, Bcl-2, Cox-2, p53 p73 by immunohistochemistry. HPV DNA detected PCR, activity PCR-ELISA, AI TUNEL assay....
To describe the retinal imaging characteristics, retinopathy management strategies and visual outcomes in cases of diabetes with chronic myeloid leukaemia.Retrospective observational study.Patients leukaemia managed at our tertiary eye care centre from January 2015 to December 2017.Detailed ophthalmic systemic evaluation, treatment follow-up records were reviewed. The main measures studied acuity, intra-ocular pressure, severity, surgical indications techniques.Of six patients studied, three...
retina.
To compare the outcomes of 400-μm microkeratome head with 350-μm Descemet stripping automated endothelial keratoplasty (DSAEK) in a prospective comparative study.Twenty cases pseudophakic bullous keratopathy were randomly allocated into two groups. Group 1 underwent slow, single-pass head, whereas group 2 standard technique DSAEK using head. The primary outcome measures best-corrected visual acuity (BCVA) at 6 months.Groups comparable baseline characteristics. mean central graft thickness...
A 26-year-old otherwise healthy female with no known systemic illness presented sudden painless dimness of vision in the left eye for 1 day. Systemic examination was within normal limits blood pressure 126/72 mmHg. Her best-corrected visual acuity 20/20 right and 20/200 eye. Anterior segments were normal. Left fundus revealed a white patch along territory cilioretinal arteries disc edema, dilated tortuous vessels, intraretinal hemorrhages [Fig. 1a]. Swept source optical coherence tomography...
A 32-years-old female was referred for a mass in her left eye detected on routine examination. The ocular examination normal with unaided visual acuity of 20/20 eye. There were no signs trauma/inflammation. single, pigmented, free-floating cyst noted the anterior vitreous [Fig. 1a and c] that showed speckled bright areas infrared reflectance imaging 1b]. In view symptoms, patient advised conservative management. These cysts have been reported rarely. may represent choristoma hyaloid vascular...
In the year 1991 Van der Bruggen P et al. cloned and named MAGE-1 gene that encodes MZ2E antigen, which is expressed in melanoma tissues cell lines (van al., 1991).Since then based on sequence similarity MAGE family has expanded to more than 60 genes (Chomez 2001).According their chromosomal location tissue-specific expression pattern, all members of this are categorized into two groups; type I (cancer testis specific) II (ubiquitous) MAGE.MAGEA sub-family 12 starting from MAGEA1 MAGEA12,...
We report an unusual case of posttraumatic isolated posterior capsular rupture with dislocation the lens nucleus in presence intact anterior capsule. The patient had pars plana vitrectomy lensectomy and multipiece intraocular placement ciliary sulcus over capsule left eye. role ultrasonography ultrasound biomicroscopy preoperative evaluation capsulolenticular status subsequent management is discussed.
Case Report A 35-year-old female presented with gradually progressive visual loss in both eyes (OU) which started as night blindness a decade ago. Best-corrected acuity OU was light perception only. Anterior segment unremarkable. Fundus revealed arteriolar attenuation and diffuse bone-spicule pigmentation involving the macula [Fig. 1a b]. Vascular telangiectasia lipid exudation were present temporal inferior retina OU. In right eye (OD), optic disc not evident distinctly due to prepapillary...
The purpose of this case series is to describe the varied presentation Torpedo lesions fundus and multimodal imaging features in three eyes patients. Two patients presented with typical topography, i.e., temporal fovea. One patient revealed lesion inferonasal disc head pointing toward disc. All had an attenuation outer retinal layers on optical coherence tomography. showed additional large subretinal cleft. Variable hypoautofluorescence area torpedo was noted. To conclude can present at...
Nutrition is a science which focuses on the overall nourishment of body and impacts health. A well-balanced diet very important for pregnancy, rich in nutrients good normal birth weight fetal Nutritional deficiency during pregnancy common it results extreme neonatal outcomes. Hence, this study was conducted with an aim to food choices vegetarian non-vegetarian mothers Madhya Pradesh. This explores dietary habits various pregnant women suggest vital healthy offspring. self-structured...
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A 25-year-old man presented with retinal detachment in his right eye 20 days after pars plana vitrectomy, epiretinal membrane peeling and endolaser assisted panretinal photocoagulation performed for non-resolving vitreous haemorrhage secondary to Eales disease. Inferior retina of the showed multiple (around 120) holes relation previous marks. The patient was managed repeat silicone oil infusion. aetiology holes, precautions prevent them their management are described.
A 12-year-old girl presented with decreased vision in OS since early childhood. OD was normal. revealed best-corrected visual acuity of hand movements −9.0 diopters sphere, large exotropia, and posterior subcapsular cataract nasally [Fig. 1a]. Fundus 1b] showed extensive myelinated retinal nerve fibers (MRNFs) persistent hyperplastic primary vitreous (PHPV) the form a fibrous stalk extending from optic disc to lens. Interestingly, while MRNFs are associated axial myopia, PHPV is smaller...