A5004010865- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Acute Myocardial Infarction Research
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Sepsis Diagnosis and Treatment
- Vascular Procedures and Complications
- Coronary Interventions and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Infective Endocarditis Diagnosis and Management
- Peripheral Artery Disease Management
- Trauma and Emergency Care Studies
- Antiplatelet Therapy and Cardiovascular Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Vasculitis and related conditions
- Cardiac, Anesthesia and Surgical Outcomes
- Metabolism, Diabetes, and Cancer
- Sarcoidosis and Beryllium Toxicity Research
- Transplantation: Methods and Outcomes
- Emergency and Acute Care Studies
- Inflammasome and immune disorders
- Cardiac tumors and thrombi
Ascension
2024
Columbia University
2021-2022
Seton Medical Center Austin
2022
Washington University in St. Louis
2018-2021
The University of Texas at Austin
2021
Barnes-Jewish Hospital
2020-2021
Cardiovascular Systems (United States)
2020
University of Missouri–St. Louis
2020
The University of Texas Health Science Center at Houston
2015-2018
The University of Texas MD Anderson Cancer Center
2017
Metabolic and structural remodeling is a hallmark of heart failure. This involves activation the mTOR (mammalian target rapamycin) signaling pathway, but little known on how intermediary metabolites are integrated as metabolic signals.We investigated control cardiac glycolysis explored potential glucose 6-phosphate (G6P) to regulate glycolytic flux activation.We developed kinetic model cardiomyocyte carbohydrate metabolism, CardioGlyco, study myocardial G6P levels. analysis revealed that...
BACKGROUND:In the setting of severe sepsis and septic shock, mortality increases when lactate levels are ≥ 4 mmol/L.However, consequences lower in this population not well understood.The study aimed to determine in-hospital associated with shock initial < mmol/L.METHODS: This is a retrospective cohort patients admitted over 40-month period.Totally 338 were divided into three groups based on values.Group 1 had 2 mmol/L; group 2: 2-4 3: mmol/L.The primary outcome was mortality.RESULTS: There...
Abstract Background Prolonged length of stay (LOS) and post‐acute care after percutaneous coronary intervention (PCI) is common costly. Risk models for predicting prolonged LOS have limited accuracy. Our goal was to develop validate using artificial neural networks (ANN) predict > 7days need PCI. Methods We defined as ≥7 days patients discharged to: extended care, transitional unit, rehabilitation, other acute hospital, nursing home or hospice care. Data from 22 675 who presented with ACS...
Background: Transradial percutaneous coronary intervention (PCI; TRI) reduces adverse outcomes when compared with transfemoral PCI (TFI). However, TRI is also used less in high-risk patients. It remains unknown how baseline patient risk influences access-site choice among operators and whether the absolute benefit of greater patients at high for bleeding, acute kidney injury (AKI), death. Methods: We analyzed 28 005 PCIs performed a 7-hospital system between July, 01, 2009 April 30, 2018, to...
Abstract Objectives Therapeutic hypothermia has been shown to improve neurologic outcome and survival in out‐of‐hospital cardiac arrest ( OHCA ) following return of spontaneous circulation ROSC ), current guidelines recommend therapeutic for all comatose survivors . However, recommendations nonshockable rhythms are not as strongly supported. Our study aims provide further evidence on the use rhythms. Methods A multivariate analysis with propensity score matching was performed using a...
To compare the incidence, characteristics, and outcomes of lactate expressors nonexpressors in patients with severe sepsis septic shock.This is a retrospective cohort study shock who presented over 40-month period to an academic tertiary care center. Primary outcome interest was in-hospital mortality. Secondary were hospital length stay (LOS), Intensive Care Unit (ICU) LOS, escalation care.Three hundred thirty-eight met inclusion criteria divided into expressor group (n = 197; initial ≥2.5...
Background: Elective percutaneous coronary intervention (PCI) historically required hospitalization post procedure. Same day discharge (SDD) has emerged as a safe and cost efficient option, although the impact of coronavirus disease 2019 (COVID-19) pandemic on rates SDD associated care episode costs remains uncertain. Methods: A national sample consecutive patients undergoing elective PCI at 42 hospitals (Ascension, St.Louis, MO) between May to April 2021 were identified using internal...
Heart failure is a serious cause of morbidity and mortality worldwide. The advent implantable cardiac assist devices has generated new arsenal for treating severe heart failure. However, the potential ramifications ventricular device (VAD) usage are not fully understood. Immune modulation resulting from VAD implantation an area growing research. Although we do understand mechanisms contributing to host immune alteration, changes in cytokine concentrations, deceased lymphocyte activity, local...
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 Heart failure is a serious cause of morbidity and mortality worldwide. The advent implantable cardiac assist devices has generated new arsenal for treating severe heart failure. However, the potential ramifications ventricular device (VAD) usage are not fully understood. Immune modulation resulting from VAD implantation an area growing research. Although we do understand mechanisms contributing to host immune alteration, changes in cytokine concentrations, deceased lymphocyte...
BackgroundAortic valve replacement is recommended in symptomatic patients with severe aortic stenosis (AS) or asymptomatic reduced left ventricular ejection fraction (LVEF). The treatment algorithm of paradoxical low-flow (pLF-LG) AS not well defined. purpose this study to examine the efficacy and outcomes TAVR pLF-LG at our institution.MethodsFrom 2008 2017, we retrospectively analyzed who underwent an LVEF > 50% stratified into 4 groups based on gradient stroke volume index. were normal...
Background Balloon aortic valvuloplasty (BAV) is used in high-risk patients with severe stenosis (AS) when the benefit of transcatheter valve replacement (TAVR) or surgical (SAVR) unclear. Our objective was to identify clinical echocardiographic features that likely from BAV. Methods We studied 141 consecutive who underwent BAV July, 2011 October, 2017. Clinical characteristics, routine parameters, and speckle tracking imaging global longitudinal strain (GLS) were assessed before after The...