A5021592376- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Ginseng Biological Effects and Applications
- Barrier Structure and Function Studies
- Tryptophan and brain disorders
- Connexins and lens biology
- Metabolomics and Mass Spectrometry Studies
- Sarcoma Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Pharmacological Effects of Natural Compounds
- Cancer-related cognitive impairment studies
- Diet and metabolism studies
- Cardiac Arrhythmias and Treatments
- Biochemical effects in animals
- Drug-Induced Hepatotoxicity and Protection
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Natural product bioactivities and synthesis
- Neurological Disease Mechanisms and Treatments
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Calcium signaling and nucleotide metabolism
- Medicinal plant effects and applications
- Cardiovascular Effects of Exercise
- MicroRNA in disease regulation
Hunan University
2020-2025
Hunan University of Traditional Chinese Medicine
2019-2024
People's Hospital of Xinjiang Uygur Autonomous Region
2024
Education Department of Hunan Province
2023
Chongqing Cancer Hospital
2020-2022
Chongqing University
2020-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2020
Army Medical University
2013-2015
Xinqiao Hospital
2014-2015
Taipei Hospital
2013-2014
Interferon-γ (IFN-γ) plays an important role in intestinal barrier dysfunction. However, the mechanisms are not fully understood. As hypoxia-inducible factor-1 (HIF-1) is a critical determinant response to hypoxia and inflammation, which has been shown be deleterious function, we hypothesized that IFN-γ induces loss of function through regulation HIF-1α activation function. In this study, detected expressions tight junction proteins IFN-γ-treated T84 epithelial cell line. led increase...
Depression is an inflammation-associated disease that results in major depression as inflammation increases and progresses. Ginsenoside Rg1 (Rg1), the bioactive ingredient derived from ginseng, possesses remarkable anti-depressant anti-inflammatory effects. Our previous studies showed pathogenesis of was concomitant with acceleration connexin43 (Cx43) ubiquitin degradation, while could upregulate Cx43 expression to attenuate depression. However, whether ubiquitination specific correlation...
Hypericin is widely utilized for its precise antidepressant properties, but exact mechanism remains unclear. Gap junctions, which were predominantly expressed in astrocytes the central nervous system, are concerned with pathogenesis of depression. However, role hypericin gap junctional dysfunction depression has rarely been investigated. Here, we found that junctions ultra-structurally broadened chronic unpredictable stress (CUS) rat model depression, while repaired junctions. Suppression by...
The aim of our study was to compare the responses heart rate variability (HRV) with two different types hormonal substitution therapy (HT) in post-menopausal women (cross-sectional study) and reveal an effect HT shortly after beginning its administration (follow-up study). To elucidate influence menopause effects protocols a on autonomic control rate, we evaluated 5 groups: premenopausal (n=140), postmenopausal without (n=360), conjugated estrogen only (n=168), continuous combined...
Improper usage of acetaminophen (APAP) leads to morbidity and also mortality secondary liver damage. Ginseng could suppress APAP-induced hepatotoxicity ginsenoside Rg3 is a kind major component in ginseng against Herein, we intended estimate the beneficial function molecular mechanism on APAP-caused identified hepatoprotection.A total 50 C57BL/6J mice were divided into five random groups, each contains 10 as control, (350 mg/kg) (5, 20 + groups. These intragastric administration single dose...
The Chinese herb couple Fuzi and Ganjiang (FG) has been a classic combination of traditional medicine that is commonly used clinically in China for nearly 2000 years. Traditional suggests FG can treat various ailments, including heart failure, fatigue, gastrointestinal upset, depression. Neuroinflammation one the main pathogenesis many neurodegenerative diseases which microglia cells play critical role occurrence development neuroinflammation. proven to have an efficient therapeutic effect...