A5007845875- HIV Research and Treatment
- interferon and immune responses
- HIV/AIDS Research and Interventions
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Mosquito-borne diseases and control
- HIV-related health complications and treatments
- Virology and Viral Diseases
- Vector-borne infectious diseases
- Herpesvirus Infections and Treatments
- Peripheral Neuropathies and Disorders
- HIV/AIDS drug development and treatment
- HIV, Drug Use, Sexual Risk
- Statistical Methods in Clinical Trials
- Viral Infections and Vectors
- Hepatitis C virus research
University of Toronto
2023-2025
University of Ottawa
2017-2023
Ottawa Hospital Research Institute
2016-2023
Ottawa Hospital
2016-2023
HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of different anatomical compartments to viral reservoir humans remains unknown. We performed an extensive characterization reservoirs two men who donated their bodies cure research and had been on suppressive ART for years. DNA is detected all tissues, with large variations across between participants. Intact genomes represent 2% 25% proviruses participants are mainly secondary lymphoid organs, spleen...
The causative agent of Lyme disease, Borrelia burgdorferi, is endemic to Canada, the northeastern United States, northern California, and temperate European regions. It rarely associated with a travel-related exposure. In this report, we describe resident southern Ontario, Canada who developed rash, fever, cranial nerve VII XII palsies following 12 day trip Ecuador Galapagos islands approximately four weeks prior referral our center. Comprehensive microbiological work-up was notable for...
The latent HIV-1 reservoir represents the primary barrier to eradication of infection. design novel reservoir-clearance strategies, however, is impeded in part by inability distinguish latently HIV-infected cells from uninfected cells. Significant impairment type I interferon (IFN-I) response observed during productive Although this remains poorly described context infection, presence potential defects may serve as a therapeutic target. Therefore, IFN-I pathways were characterized using two...
Cells latently infected with human immunodeficiency virus (HIV) evade immune- and drug-mediated clearance. These cells harbor intracellular signaling defects, including impairment of the antiviral type I interferon response. Such defects have also been observed in several cancers exploited for development therapeutic oncolytic viruses, recombinant Maraba (MG1). We therefore hypothesized that MG1 would infect eliminate HIV-1, while sparing healthy uninfected cells. Preferential infection...
The use of unique cell surface markers to target and eradicate HIV-infected cells has been a longstanding objective HIV-1 cure research. This approach, however, overlooks the possibility that intracellular changes present within may serve as valuable therapeutic targets. For example, identification dysregulated antiviral signaling in cancer led characterization oncolytic viruses capable preferentially killing cells. Since impairment cellular machinery proposed mechanism by which evades...