A5100429075- Traditional Chinese Medicine Analysis
- Microfluidic and Capillary Electrophoresis Applications
- Metabolomics and Mass Spectrometry Studies
- Analytical Chemistry and Chromatography
- Gout, Hyperuricemia, Uric Acid
- Receptor Mechanisms and Signaling
- Pancreatic function and diabetes
- Genetic and Kidney Cyst Diseases
- Natural product bioactivities and synthesis
- Indoor Air Quality and Microbial Exposure
- Pharmacological Effects of Natural Compounds
- Engine and Fuel Emissions
- Nanoplatforms for cancer theranostics
- Phytochemistry and Biological Activities
- Odor and Emission Control Technologies
- Analytical Methods in Pharmaceuticals
- Folate and B Vitamins Research
- Luminescence and Fluorescent Materials
- Advanced Malware Detection Techniques
- Electrochemical Analysis and Applications
- Ginkgo biloba and Cashew Applications
- Neurological Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- Kruppel-like factors research
- Biodiesel Production and Applications
Xuzhou Medical College
2018-2023
Wuhan University of Technology
2018
Shenyang Pharmaceutical University
2016-2017
Daping Hospital
2006
Abstract Green and enhanced extraction of bioactive ingredients from medicinal plants has become a hot research field, deep eutectic solvents have been considered as novel kind sustainable in the process. In this study, hydrogen bond acceptor (choline chloride, etc.) donor ( l ‐malic acid, were used to prepare different kinds extract coumarins Cortex Fraxini . The conditions, including composition moisture content solvents, time, liquid‐solid ratio, systematically optimized basing on yield...
Prevailing strategies directing early-phase drug discovery heavily rely on equilibrium-based metrics such as affinity, which overlooks the kinetic process of a molecule interacting with its target. Herein, we developed number vasopressin V2 receptor (V2R) antagonists divergent binding affinities and kinetics for autosomal dominant polycystic kidney disease (ADPKD). Surprisingly, residence time V2R antagonists, but not their was correlated efficacy in both ex vivo models ADPKD. We envision...
Cortex Fraxini is an important traditional Chinese medicine. In this work, a rapid and reliable homogenate extraction method was applied for the fast Fraxini, optimized by response surface methodology. Ultra high performance liquid chromatography combined with Fourier transform ion cyclotron resonance mass spectrometry gas were established separation characterization of constituents Fraxini. Liquid conducted on C18 column (150 mm × 2.1 mm, 1.8 μm), performed capillary 5%...
Abstract Cortex Fraxini is an important traditional Chinese herbal medicine used for the treatment of gout and hyperuricemia. An efficient rapid ultra‐performance liquid chromatography mass spectrometry method was developed validated simultaneous quantitation six coumarins (aesculin, fraxin, aesculetin, fraxetin, sopoletin 7‐hydroxycoumarin) in normal hyperuricemic rats plasma after oral administration Fraxini. The could successfully be applied pharmacokinetics studies. pharmacokinetic...
Tumor-associated macrophages (TAMs) play a critical role in tumor progression and metastasis. Modulation of TAM polarization is one the most effective strategies to change immunosuppressive microenvironment (TME). In this study, organic polymer nanoparticles (CPHT) were prepared using hyaluronic acid (HA)-conjugated disulfide-bonded polyethylene imide (PEIS) as carrier through self-assembly strategy. These modified by transferrin (Tf) loaded with chlorin e6 (Ce6). The results showed that...
The ATP-binding cassette (ABC) transporter ABCG2 is a significant urate with high capacity, and it plays crucial role in the development of hyperuricemia gout. Therefore, has potential to be targeted for therapeutic interventions. Cortex Fraxini, traditional Chinese medicine (TCM), been found possess anti-hyperuricemia properties. However, specific constituents Fraxini responsible this effect are still unknown, particularly compound that reducing uric acid levels vivo. In study, we propose...
29 prototype compounds and 52 metabolites of Cortex Fraxini are identified in by FT-ICR-MS.
This paper aims to investigate the effects of HE20 hydrous ethanol gasoline (20% v/v) on cycle-to-cycle variation in a spark ignition engine. Comparative experiments were carried out port fuel injection engine fueled with HE20, anhydrous (E20) and pure (E0). The was run at speeds 1200 rpm, 1600 2000 rpm loads varied from 10 Nm 50 for each speed, because higher cyclic occurs relatively low load. Our experimental results show that influence depends working conditions. At loads, combustion both...
Abstract 3-(Methylene-bis(1′,4′-phenylene) dicarbamate-2,3-bis(3,5-dimethylphenylcarbamate)-amylose)-2-hydroxylpropoxy-propylsilyl-appended silica particles (DMP-AM-HPS), a new type of 2, 3-regioselectively substituted amylose-immobilized chiral stationary phase (CSP) for high-performance liquid chromatography (HPLC), have been prepared by treatment 3-(2,3-dihydroxyl-propoxy)-propylsilyl with 2,3-bis(3,5-dimethylphenylcarbamate)-amylose and 4,4′-diphenylmethane diisocyanate. The chemical...
The discovery of novel chemical entities targeting G protein-coupled receptors (GPCRs) is usually guided by their receptor affinity. However, traditional affinity assay methods and hit identification procedures are laborious expensive. In this work, the type-2 vasopressin (V2R) was chosen as a prototypical GPCR. Membrane fragments from cells highly expressing SNAP-V2R were immobilized on surface glass microfiber (GMF) coated with O6-benzylguanine (BG). This achieved transferring benzyl group...
This study was conducted to evaluate the adverse health effects on rabbits exposed SO2 emitted indoors from burning coals, and compare differences between coal-biomass briquette (B.B.) raw coal (R.C.). Thirty-six male were divided equally into three groups at random, then R.C., B.B., third without (Control) for 90 days. Data showed that average concentration of in 24 h R.C. 13.04 mg m−3, which 5-fold greater than B.B. (2.68 m−3) 31-fold higher control (0.41 m−3). After 45 days, numbers...