A5075953535- Antibiotic Resistance in Bacteria
- Lung Cancer Treatments and Mutations
- Synthesis and Biological Evaluation
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- Pneumonia and Respiratory Infections
- RNA modifications and cancer
- Magnesium Alloys: Properties and Applications
- Genomics, phytochemicals, and oxidative stress
- Zeolite Catalysis and Synthesis
- Lung Cancer Research Studies
- Hydrogen Storage and Materials
- Mesoporous Materials and Catalysis
- Mycobacterium research and diagnosis
- Pleural and Pulmonary Diseases
- Tuberculosis Research and Epidemiology
- Molten salt chemistry and electrochemical processes
- Acute Myeloid Leukemia Research
- MicroRNA in disease regulation
- Pharmaceutical and Antibiotic Environmental Impacts
- Glutathione Transferases and Polymorphisms
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 Clinical Research Studies
South China University of Technology
2018-2025
Guangzhou Medical University
2013-2025
Guangzhou First People's Hospital
2013-2025
Wenzhou Medical University
2024
Southeast University
2023
Harbin Normal University
2006-2021
Huazhong University of Science and Technology
2020
Tongji Hospital
2020
First Affiliated Hospital of Jinan University
2018
Brigham and Women's Hospital
2013
To analyze the clinical characteristics of 2019 novel coronavirus (2019-nCoV) pneumonia and to investigate correlation between serum inflammatory cytokines severity disease.
This study was to investigate the expression correlation between long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1), miR-200a-3p and programmed death-ligand (PD-L1) in non-small cell cancer (NSCLC), their roles NSCLC. Real-time polymerase chain reaction (PCR) performed detect expressions of MALAT1, PD-L1 NSCLC tissues cells for analysis. The starBase Targetscan databases were used predict binding sites MALAT1 miR-200a-3p, PD-L1, respectively. targeting...
OBJECTIVE. The purpose of this study was to explore the value CT in diagnosis coronavirus disease (COVID-19) pneumonia, especially for patients who have negative initial results reverse transcription–polymerase chain reaction (RT-PCR) testing.
Polymorphonuclear neutrophils (PMN) are essential components of the host defense system against a wide variety pathogens. We report here novel finding that freshly isolated human PMN constitutively express detectable surface levels IL-2R beta, but not alpha, as analyzed by flow cytometry. Northern blot analysis confirmed constitutive expression mRNA for beta in PMN. Scatchard using 125I-labeled IL-2 demonstrated presence approximately 600 intermediate binding per PMN, with dissociation...
Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible lung disease with high mortality limited treatment options. While single-dose bleomycin-induced models are commonly used to investigate the pathogenesis of IPF, they fail adequately replicate complex pathological features in human patients, thereby hindering comprehensive investigations. Previous studies utilizing repetitive bleomycin injections have demonstrated closer resemblance IPF pathology; however, time-...
Background Pleural effusion (PE), frequently encountered in clinical practice, can arise from a variety of underlying conditions. Accurate differential diagnosis PE is crucial, as treatment and prognosis are heavily dependent on the etiology. However, diagnosing cause remains challenging, relying mycobacteriological methods that lack sensitivity time-consuming, or histological examinations require invasive biopsies. The recent advancements metagenomic next-generation sequencing (mNGS) have...
Abstract In addition to T cells, NK B and monocytes, we provide new evidence that human polymorphonuclear neutrophils (PMN) can be functionally activated by IL-2 via binding IL-2R beta expressed on the cell surface. Brief exposure of normal PMN rIL-2 enhanced both transcriptional translational expression TNF-alpha. The release TNF-alpha protein IL-2-treated was inhibitable a specific mAb against IL-2-R beta. response dose time dependent with increase in mRNA detected maximally 3 h after...
Lung epithelial cell death is a prominent feature of hyperoxic lung injury, and has been considered very important underlying mechanism acute injury (ALI) respiratory distress syndrome (ARDS). Here we report on novel involved in cytoprotection homeostasis after oxidative stress. p62 (sequestosome 1; SQSTM1) ubiquitously expressed cellular protein. It interacts with ubiquitinated proteins autophagic marker light chain 3b (LC3b), thus mediating the degradation selective targets. In this study,...
Abstract Introduction The activation of STING (stimulator interferon genes) pathway enhances antitumor immunity in small‐cell lung cancer (SCLC), while the DNA damage induced by non‐cGAMP‐based agonists is a potent inducer activity. Here, we investigate intrinsic expression cells and evaluate value combination ATR TOP1 inhibitors enhancing immunity. Methods was assessed at mRNA protein levels SCLC normal tissues. Transcriptomic subsets were identified based on STING‐related genes. Distinct...
Immune checkpoint inhibitor-related interstitial pneumonia (CIP) poses a diagnostic challenge due to its radiographic similarity other pneumonias. We developed non-invasive model using CT imaging differentiate CIP from pneumonias (OTP). analyzed and OTP patients after the immunotherapy five medical centers between 2020 2023, randomly divided into training validation in 7:3. A radiomics was random forest analysis. new then built by combining independent risk factors for CIP. The models were...
The reduced graphene oxide (rGO) supported cobalt nanocrystals have been synthesized through an in situ crystal growth method using Co(acac)2 under solvothermal conditions by DMF as the solvent. By carefully controlling reaction temperature, phase transition of from cubic to hexagonal has achieved. Moreover, microscopic structure and morphology well reduction process composite investigated detail. It is found that oxygen-containing functional groups on (GO) can greatly influence formation Co...
Sex-related differences in cancer epidemiology, tumor biology, immune system activity, and pharmacogenomics have been suggested to be important considerations for precision control. Here we elucidated systematically sex biases genetic variants, gene expression profiles, immunological landscapes of lung adenocarcinoma patients (LUADs) with different ancestry smoking status.Somatic mutation mRNA data Asian Non-Asian LUADs were obtained from public databases. Sex-biased mutations, expression,...
Induction of IL-8 gene expression was investigated in IL-2-stimulated circulating peripheral blood polymorphonuclear neutrophils (PMN). Brief exposure normal PMN to human rIL-2 enhanced both transcriptional and translational IL-8. The mRNA first detectable by 3 h, followed a continuous maintenance high levels up 18 h. Maximal transcription obtained with 1000 U/ml IL-2, which achieved the level observed known neutrophil-activating factors such as granulocyte macrophage-CSF Candida albicans....
Introduction Multidrug-resistant Acinetobacter baumannii (A. baumannii) has become one of the greatest threats worldwide to therapeutic management infections. Our previous research confirmed an in vitro synergistic effect amlodipine and imipenem against A. baumannii, this study is designed understand its mechanism. Methods Sixty-four non-duplicate isolates were collected tested for antimicrobial susceptibility by disk diffusion method. PCR amplification sequencing used identify presence...
Long‑noncoding RNAs (lncRNAs) are crucial for the pathophysiology of acute lung injury (ALI). Metastasis‑associated adenocarcinoma transcript 1 (MALAT1) suppresses inflammatory responses via microRNA (miR)‑146a in lipopolysaccharide (LPS)‑induced ALI. However, molecular mechanisms underlying MALAT1‑mediated regulation cell proliferation and apoptosis LPS‑induced ALI remain unclear. In present study, it was found that LPS treatment upregulated MALAT1 expression suppressed A549 cells....