A5049431699- Metabolism, Diabetes, and Cancer
- Antioxidant Activity and Oxidative Stress
- Peroxisome Proliferator-Activated Receptors
- 3D Printing in Biomedical Research
- Cardiovascular Disease and Adiposity
- Peripheral Artery Disease Management
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Microfluidic and Bio-sensing Technologies
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Cancer Cells and Metastasis
- Healthcare Systems and Public Health
- Diet, Metabolism, and Disease
- Effects and risks of endocrine disrupting chemicals
- Barrier Structure and Function Studies
- Physical Education and Training Studies
- Venous Thromboembolism Diagnosis and Management
Brazilian Center for Research in Energy and Materials
2021-2025
Brazilian Biosciences National Laboratory
2021-2025
Universidade Estadual de Campinas (UNICAMP)
2015-2023
Obesity is one of the main risk factors for type 2 diabetes, and peroxisome proliferator-activated receptor γ (PPARγ) considered a promising pathway on insulin sensitivity adipose tissue metabolism. The search molecules acting as sensitizers have increased, especially that block PPARγ-Ser273 phosphorylation, without reaching full agonism. We evaluated in vivo effects AM-879, PPARγ non-agonist, found AM-879 exerts different mice depending dose. At lower doses, this ligand decreased BAT,...
Since the removal of thiazolidinediones (TZDs) from market, researchers have been exploring alternative anti-diabetic drugs that target PPARγ without causing adverse effects while promoting insulin sensitization by blocking serine 273 phosphorylation (Ser273 or S273). Nonetheless, underlying mechanisms relationship between resistance and S273 are still largely unknown, except for involvement growth differentiation factor (GDF3) regulation in process. To further investigate potential...