A5020593609- Estrogen and related hormone effects
- Retinoids in leukemia and cellular processes
- 3D Printing in Biomedical Research
- Antioxidant Activity and Oxidative Stress
- DNA and Nucleic Acid Chemistry
- Nuclear Receptors and Signaling
- Viral Infectious Diseases and Gene Expression in Insects
- Receptor Mechanisms and Signaling
- Agriculture, Plant Science, Crop Management
- Effects and risks of endocrine disrupting chemicals
- Microfluidic and Bio-sensing Technologies
- Acute Lymphoblastic Leukemia research
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Skin Protection and Aging
- Thyroid Disorders and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Innovative Microfluidic and Catalytic Techniques Innovation
Natura (Brazil)
2023-2024
Brazilian Biosciences National Laboratory
2014-2022
Brazilian Center for Research in Energy and Materials
2014-2022
Universidade Estadual de Campinas (UNICAMP)
2019-2020
Pontifícia Universidade Católica de Campinas
2020
Laboratório Nacional de Ciência e Tecnologia do Bioetanol
2014
Transcriptional regulation controlled by thyroid hormone receptor (TR) drives events such as development, differentiation, and metabolism. TRs may act either homodimers or heterodimers with retinoid X (RXR). Thyroid T3 preferentially binds TR-RXR heterodimers, which activate transcription through coactivator recruitment. However, it is unclear whether also be responsive to the canonical RXR agonist 9-cis retinoic acid (9C) in context of physiological gene regulation. New structural studies...
Estrogen receptor α (ERα) is a regulatory protein that can access set of distinct structural configurations. ERα undergoes extensive remodeling as it interacts with different agonists and antagonists, well transcription activation repression factors. Moreover, breast cancer tumors resistant to hormone therapy have been associated the imbalance between active inactive states. Cancer-activating mutations in play crucial role this promote progression cancer. However, rate also be increased by...
Thyroid hormone receptors (TRs) are responsible for mediating thyroid (T3 and T4) actions at a cellular level. They belong to the nuclear receptor (NR) superfamily execute their main functions inside cell nuclei as hormone-regulated transcription factors. These also exhibit so-called 'nonclassic' actions, which other proteins, apart from coregulators nuclei, regulate activity. Aiming find alternative pathways of TR modulation, we searched interacting proteins found that PDIA1 interacts with...
A NAM, comprising a microphysiological system of three organ equivalents (skin, liver and intestine), combined with toxicological gene signature analysis, is promising tool to assess chemical safety.