A5034565330- Prostate Cancer Treatment and Research
- Growth Hormone and Insulin-like Growth Factors
- Hormonal and reproductive studies
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Urinary Bladder and Prostate Research
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Thyroid Disorders and Treatments
- Urologic and reproductive health conditions
- Pelvic floor disorders treatments
- Hormonal Regulation and Hypertension
- Sexual Differentiation and Disorders
- Kidney Stones and Urolithiasis Treatments
- RNA Research and Splicing
- Mass Spectrometry Techniques and Applications
- Lipid metabolism and disorders
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Urological Disorders and Treatments
- Mechanisms of cancer metastasis
- Thyroid and Parathyroid Surgery
- Adrenal and Paraganglionic Tumors
- Biopolymer Synthesis and Applications
National Yang Ming Chiao Tung University
2011-2025
Taipei Medical University
2024-2025
Czech Academy of Sciences, Institute of Microbiology
2021-2024
Taipei Medical University Hospital
2010-2024
Taipei Veterans General Hospital
2011-2015
National Central University
2014
Merck & Co., Inc., Rahway, NJ, USA (United States)
1993-2011
Baylor College of Medicine
1981-1999
Cornell University
1999
New York State College of Veterinary Medicine
1999
Abstract To investigate the effect of hypophyseal transection (HST) on GH secretagogue activity non-peptidyl L-692,585 in conscious pig, male castrated swine were randomly assigned to either a stalk group (HST; n =3) or sham-operated control (SOC; =3). Treatments administered (100 γg/kg), human GH-releasing factor(1–29)NH 2 (GRF; 20 γg/kg) + GRF (20 days −7 −3 before surgery and +3 +8 after surgery. evaluate integrity pituitary gland, animals challenged with corticotropin-releasing hormone...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPurification and characterization of androgen receptor from steer seminal vesicleChing H. Chang, David R. Rowley, Thomas J. Lobl, Donald TindallCite this: Biochemistry 1982, 21, 17, 4102–4109Publication Date (Print):August 1982Publication History Published online1 May 2002Published inissue 17 August 1982https://doi.org/10.1021/bi00260a029RIGHTS & PERMISSIONSArticle Views63Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the...
Trigonelline (TGN), an alkaloid identified in medicinal plants such as coffee (Coffea spp.) and fenugreek (Trigonella foenum-graecum), has demonstrated significant anticancer properties across various malignancies, yet its efficacy bladder cancer (BLCA) remains underappreciated. This study investigates TGN's role modulating stem cells (CSCs) the tumor microenvironment (TME), two key contributors to BLCA progression chemoresistance. Through comprehensive bioinformatics analyses of patient...
The androgen receptor has been purified from rat ventral prostate cytosol by a combination of differential DNA-Sepharose 4B chromatography and testosterone 17 beta-hemisuccinyl-3,3'-diaminodipropylamine-Sepharose affinity chromatography. Approximately 8 micrograms protein was obtained 38 g prostate, with yield 24%. approximately 120 000-fold. Silver nitrate staining sodium dodecyl sulfate (NaDodSO4)-polyacrylamide gel revealed major polypeptide band migrating at 86 000 daltons. Affinity...
Prostate vaporization and enucleation is a novel treatment option for bladder outlet obstruction caused by benign prostate enlargement. This surgical technique, however, has not yet been standardized. We present our findings of using high-power thulium laser to accomplish vapoenucleation the (ThuVEP).We prospectively collected analyzed data from 29 patients who underwent ThuVEP between August 2010 May 2012. The control group included 30 traditional transurethral resection (TURP). Operative...
The efficacy of thulium laser prostate enucleation (ThuLEP) for large prostates is unclear. This study aimed to explore the expanded utility 150–200-W ThuLEP by studying patients with a (> 80 mL). We retrospectively reviewed records 125 glands mL) who underwent performed single surgeon from June 2012 2016. data our previous pilot were used as control. Operative variables, patient profiles, preoperative and postoperative urine flow rates, volume, international symptom score (IPSS) recorded...
A method of collecting hypophyseal portal blood (HPB) in conscious pigs was used to show the relationship between GRF and somatostatin (SRIF) concentration peripheral GH response. Six male castrate (approximately 63 kg body weight) had HPB jugular collected individually for an average 175 min each. Twenty-seven spontaneous pulses were detected 1050 total collection. Of associations examined, only significant finding that pulse maxima occurred nonrandomly within periods SRIF descent (63%; P =...
L-700,653 is a potent nonpeptidyl GH secretagogue consisting of benzolactam structure: (4'-[[3(R)-[[3-[(2(S),3-dihydroxypropyl) amino]3-methyl-1-oxobutyl]amino]2,3,4,5-tetrahydro-2-oxo-1H-1-benzaze pin- 1-yl]methyl][1,1'-biphenyl]2-carboxamide hydrochloride). When administered sc by Medi-Jector device at 0, 0.003, 0.01, 0.03, and 0.1 mg/kg BW to male castrated swine (approximately 50 kg BW), stimulated dose-related increases in peak plasma concentrations 20% (P = NS), 150% 250% < 0.05), 340%...
Neuroendocrine prostate cancer (PCa), an aggressive subtype of PCa, can arise de novo or from pre-existing castration-resistant especially after treatment with new-generation androgen receptor signaling inhibitors (ARSIs); thus, it is a major cause resistance to ARSIs. Lineage plasticity drives the transformation adenocarcinoma cells receptor-driven luminal cell program alternative neuroendocrine transdifferentiation phenotype, which has been recognized as key mechanism in PCa development....
In this manuscript we have characterized the androgen receptor from human benign prostatic hypertrophied (BPH) tissue. BPH tissue was obtained fresh surgery, ground, and frozen in liquid nitrogen. Tissue homogenized 10 mM Tes buffer (pH 7.4 at 25 degrees C) containing 0.25 M sucrose, 20 Na2MoO4, 12 monothioglycerol, 1.5 EDTA. Cytosol labeled with (3H)-R1881 (0.5-10 nM) +/- a 100-fold excess of R1881 500-fold triamcinolone acetonide to identify specific sites. An exchange assay developed,...
Here, we report the case of a 63-year-old female patient who presented with emptying symptoms and was subsequently diagnosed delayed labial agglutination. The adhered labia minora were divided by blunt dissection, topical estrogen ointment applied after surgery. patient’s voiding completely resolved no recurrence agglutination noted 3 months Labial is rare but often manifests nonspecific symptoms. Nevertheless, it can be easily on physical examination successfully treated surgical...
L-163,255 is a potent orally active spiropiperidine GH secretagogue. When administered iv or orally, caused to be increased in dose-related manner, with return baseline by 90 min. After administrations of saline and at 1, 3, 10 micrograms/kg, areas under the curves (GH AUCs) over 120 min were 377 +/- 136, 1151 413 (P < 0.05), 795 = NS), 1770 416 ng.min/ml 0.01), peak concentrations 8 16 7 17 5 43 12 ng/ml respectively. No changes plasma cortisol noted. oral 10, 30 AUCs 180 1133 154, 1246 129...
Abstract. The activity of the growth hormone secretagog, L‐163,255, on (GH), hormone‐releasing factor (GRF), and somatostatin (SRIF) levels was evaluated in a porcine model hypophyseal portal blood (HPB) collection. Young, castrated pigs had HPB jugular collected for ≈ 300 min. collection divided into discrete periods: baseline (BL) 180 min; GH response period (RSP) 90 positive control following GRF bolus, 30 RSP dominant (DOM) tail (TL). spontaneous relationship between SRIF peripheral...
Journal Article Activity of a novel nonpeptidyl growth hormone secretagogue, L-700,653, in swine Get access C H Chang, Chang 1Department Biochemistry and Physiology, Merck Research Laboratories, Rahway, New Jersey 07065-0900. Search for other works by this author on: Oxford Academic Google Scholar E L Rickes, Rickes F Marsilio, Marsilio McGuire, McGuire S Cosgrove, Cosgrove J Taylor, Taylor Chen, Chen Feighner, Feighner N Clark, Clark R De Vita Endocrinology, Volume 136, Issue 3, 1 March...
ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Discovery of (2R)-2-(3-{3-[(4-Methoxyphenyl)carbonyl]-2-methyl-6-(trifluoromethoxy)-1H-indol-1-yl}phenoxy)butanoic Acid (MK-0533): A Novel Selective Peroxisome Proliferator-Activated Receptor γ Modulator for the Treatment Type 2 Diabetes Mellitus with Reduced Potential Increase Plasma and Extracellular Fluid VolumeJohn J. Acton, III, Taro E. Akiyama, Ching H. Chang, Lawrence Colwell,...
Background: Multiparametric magnetic resonance imaging (mpMRI) followed by MRI-targeted prostate biopsy is the current standard for diagnosing cancer (PCa). However, studies evaluating value of biomarkers, including health index (PHI) and its derivatives using this method are limited. We aimed to investigate efficacy PHI density (PHID) in guiding biopsies identify clinically significant PCas (csPCa). Methods: The multicenter prospectively registered database from three medical centers Taiwan...