Triple-negative breast cancer (TNBC) lacks specific therapeutic target and limits to chemotherapy is essential develop novel regimens. Increasing studies indicated that tamoxifen, a selective estrogen receptor modulators (SERMs), has anti-tumor effect in α (ERα)-negative tumor. Here, we determined whether autophagy was activated by tamoxifen TNBC cells. Moreover, CSC-3436 displayed strong growth inhibition on Next, investigated the anti-proliferation of combination plus cell death Our study...

Bladder cancer is the most common malignancy of urinary tract and arising from epithelial lining bladder. Resistance to cytotoxic therapies associated with overexpression oncogenic proteins; including HER2, Akt in chemotherapy resistance bladder cancer. Various studies demonstrated that curcuminoids, important active phenolic compounds turmeric (Curcuma longa), have anti-tumor activities a wide range human malignant cell lines. The aim this study evaluate whether curcuminoids (curcumin,...

Trigonelline (TGN), an alkaloid identified in medicinal plants such as coffee (Coffea spp.) and fenugreek (Trigonella foenum-graecum), has demonstrated significant anticancer properties across various malignancies, yet its efficacy bladder cancer (BLCA) remains underappreciated. This study investigates TGN's role modulating stem cells (CSCs) the tumor microenvironment (TME), two key contributors to BLCA progression chemoresistance. Through comprehensive bioinformatics analyses of patient...

Background and Objectives: Post-transplant anastomotic pseudoaneurysms are a rare but serious complication of renal transplantation, typically requiring graft sacrifice. This case report demonstrates novel hybrid approach for managing mycotic pseudoaneurysm while preserving function. Case report: A 56-year-old male developed at the site after cadaveric kidney presenting with recurrent infections declining Imaging confirmed pseudoaneurysm. strategy combining femoral–femoral bypass...

Mesenchymal stem cells (MSCs), such as adipose-derived (ADSCs), have the most impressive ability to reduce inflammation through paracrine growth factors and cytokines that participate in inflammation. Tumor necrosis factor (TNF)-α bioactivity is a prerequisite several inflammatory autoimmune disease models. This study investigated effects of TNF-α stimulate on ADSCs tumor microenvironment. The RNAseq analysis assay demonstrated stimulated proliferation pro-inflammatory genes correlated...

A perforated sigmoid colon cancer within an inguinal hernia is extremely rare. This unexpected finding usually discovered during surgery and causes unavoidable septic evolution. Here, we describe the case of 84-year-old man who presented with fever, abdominal distension, a painful, enlarged, left scrotum. CT showed left, incarcerated, containing adenocarcinoma (which was confirmed by histopathology). The possibility irreducible in association should be considered array diagnoses....

At present, robot-assisted radical prostatectomy (RARP) is a gold standard in prostatectomy. The aim of this study was to evaluate the incidence, risk factors, and timing occurrence inguinal hernia (IH) after RARP. We included 427 patients with prostate cancer who underwent RARP by single surgeon from February 2006 August 2017. Incidence, clinical, pathological factors were investigated assess relationship development IH. Postoperative IH occurred 29 cases (6.79% all patients), whereas 22...

This study aimed to explore the existence of circulating tumor cells (CTCs) in patients with muscle-invasive bladder cancer (MIBC) and their predictive potential for response neoadjuvant chemotherapy (NAC). From 33 blood samples MIBC patients, CTCs were isolated by cell surface markers enriched IsoFlux™ device, followed morphological immunofluorescent identification. detected at baseline all samples. Immunofluorescence confirmed origin. stratified NAC into disease control (DC) progressive...

We describe a case of gestational choriocarcinoma metastasized to the kidney and lung, which presented initially as refractory hematuria after term pregnancy 5 years earlier. A 35-year-old woman, G2P1, with previous history full-term in 2009, emergency department complaining intermittent gross for 2 months. Abdominal computed tomography showed suspicious arteriovenous malformation right thrombus within renal vein. Transarterial embolization was performed twice treat but unsuccessful, radical...

Programmed cell death ligand 1 (PD-L1) inhibitors are commonly used in treating advanced-stage urothelial carcinoma (UC). Therefore, this study evaluated the relationship between PD-L1 expression circulating tumor cells (CTCs) and treatment response to using blood samples collected from patients with UC (n = 23). Subsequently, its clinical correlation were analyzed. All had CTCs before inhibitory treatment, of which 15 PD-L1-positive CTCs. However, was not correlated biopsy samples. Patients...

Background: Prostate-specific antigen (PSA) remains the most useful marker for screening, risk categorization, and follow-up in patients with prostate cancer. In obese population, several studies have revealed that obesity may not only inversely interfere concentration of PSA, but also increase Thus, we considered using body mass weighted PSA levels, presented as serum multiplied by weight or index (BMI), instead traditional concentration, potential markers to predict locally advanced cancer...

Clinical bladder tumor histological analysis shows that high expression of S1PR1 is associated with poor patient prognosis. However, there are no studies describe the underlying mechanism. To investigate relative distribution and actual function in tumors, we analyzed multiple clinical databases combination purity immune cell infiltration simulations, as well well-defined phenotypes cancer, single-cell sequencing adjacent normal tissues further compared them cancer lines. The results showed...

To evaluate the efficacy and safety of administering a 3-month formulation triptorelin as part disease management Taiwanese men with advanced adenocarcinoma prostate.Patients newly diagnosed, locally advanced, or metastatic prostate were enrolled in our study, after informed consent was obtained. All patients received bicalutamide 50 mg daily for 28 days, starting 7 days before first injection triptorelin. A dosage 11.25 injected on Day 0 (baseline) repeated 90. Prostate-specific antigen...

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a painful recurrent condition characterized by the discomfort of bladder, and current treatment options have limited effectiveness. Prolotherapy well-known that involves injection non-biologic solutions to reduce and/or promote proliferation soft tissue, dextrose most common injectate. This study investigated effects prolotherapy in rat model IC/BPS patients with IC/BPS. We used cyclophosphamide induce rats, intravesical instillation...

There is a great interest in determining whether the expression of programmed cell death ligand 1 correlated with efficacy immune checkpoint inhibitors patients clear renal carcinoma; however, primary tumor biopsies can only provide limited information. Therefore, we explored on circulating cells, which potential predictor therapeutic response.Circulating cells were isolated from 20 carcinoma based surface markers targeting using IsoFlux device, followed by identification according to...

Urothelial carcinoma includes upper urinary tract cancer (UTUC) and bladder cancer. Although nephroureterectomy is the standard treatment for UTUC, recurrence rate approximately half tumor associated with poor prognoses. Metastases are most devastating lethal clinical situation in urothelial carcinoma. Despite its importance, few potential diagnostic biomarkers suitable early UC detection. We compared high-stage/high-grade tissues to adjacent normal using methyl-CpG binding domain protein...

Background: Combination therapy with the administration of GW5074 and sorafenib significantly induced necrotic death in various cancer cells vivo, as well prolonging survival an animal disease model due to significant suppression primary metastatic lesions. We sought determine safety, tolerability, pharmacokinetics, anti-tumor activity this co-administration patients refractory advanced solid cancers. Methods: Twelve were enrolled. Eligible subjects received different dosages one three dose...

Posterior urethral distraction injury following major pelvic trauma is a surgical challenge. Although rarely seen, cases of failure after formal reconstruction are even more problematic. We adapted the concept augmented free buccal mucosal grafts, which have been successful in anterior urethroplasty, for repairing posterior urethra these rare with aim reducing likelihood penile chordee postoperatively. During 2007-2009, four patients were candidates proposed procedure because they had...

The aim of this study was to evaluate the therapeutic response and complications high-intensity focused ultrasound for patients with localized prostate cancer. We evaluated clinical outcomes 29 who received as first-line treatment cancer at our hospital from October 2010 March 2016. Biochemical recurrence defined, according Stuttgart definition biochemical failure, prostate-specific antigen nadir plus 1.2 ng/mL. Prostate-specific levels were recorded during regular follow-up. mean follow-up...