A5019743528- Neuroscience and Neuropharmacology Research
- ATP Synthase and ATPases Research
- Career Development and Diversity
- Tryptophan and brain disorders
- Bacteriophages and microbial interactions
- Mitochondrial Function and Pathology
- Mentoring and Academic Development
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Congenital heart defects research
- Doctoral Education Challenges and Solutions
- Microbial infections and disease research
- Neuroendocrine regulation and behavior
- Enzyme Structure and Function
- Probiotics and Fermented Foods
- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Higher Education Research Studies
- Stress Responses and Cortisol
University of California, San Diego
2023-2024
Hospital for Sick Children
2021-2022
SickKids Foundation
2022
University of Toronto
2021-2022
Howard University
2019
The nadA motif is a riboswitch candidate present in various Acidobacteria species that was previously identified by bioinformatic analysis of bacterial DNA data sets. More than 100 unique representatives have been exclusively upstream genes, which code for an enzyme the biosynthetic pathway ubiquitous coenzyme NAD + . architecture RNAs suggests they use structurally similar tandem ligand-binding aptamer domains to control translation initiation. Biochemical analyses reveal first domain...
Autism spectrum disorder (ASD) and congenital heart disease (CHD) are linked on a functional genetic level. Most work has investigated CHD-related neurodevelopmental abnormalities. Cardiac abnormalities in ASD have been less studied. We the prevalence of cardiac comorbidities relative to contributors. Using high frequency ultrasound imaging, we screened 9 ASD-related mouse models (Arid1b(+/-) , Chd8(+/-) 16p11.2 (deletion), Sgsh(+/-) Sgsh(-/-) Shank3 Δexon 4-9(+/-) 4-9(-/-) Fmr1(-/-)...
Abstract In the face of a challenging climate STEM (Science, Technology, Engineering and Mathematics) higher education that is resistant to Diversity, Equity, Inclusion efforts aimed increase retain students from historically excluded groups (HEGs), there critical need for support structure ensure HEGs continue be recruited retained. The Biology Undergraduate Master's Mentorship Program (BUMMP) embodies this commitment fostering scientific identity, efficacy, sense belonging first‐generation...
Abstract Extensive evidence supports the role of immune system in modulating brain function and behaviour. However, past studies have revealed striking heterogeneity behavioural phenotypes produced from dysfunction. Using magnetic resonance imaging, we studied neuroanatomical differences among 11 distinct genetically modified mouse lines ( n = 371), each deficient a different element system. We found significant heterogeneous effect dysfunction on brains both male female mice. by imaging...
Abstract In the face of a challenging climate that is resistant to Diversity, Equity, and Inclusion (DEI) efforts, there critical need for support structure retaining students, particularly those from historically excluded groups (HEGs), in STEM. The Biology Undergraduate Master’s Mentorship Program (BUMMP) embodies this commitment fostering scientific identity, efficacy, sense belonging 1 st generation underserved undergraduate master’s students at UC San Diego. mission BUMMP cultivate...
Abstract Diverse populations of bacteriophages infect and coevolve with their bacterial hosts. Although host recognition infection occur within microbiomes, the molecular mechanisms underlying host–phage interactions a community context remain poorly studied. The biofilms (rinds) aged cheeses contain taxonomically diverse microbial communities that follow reproducible growth patterns can be manipulated under laboratory conditions. In this study, we use cheese as model for studying...
<p>Additional figures and tables</p>
<p>Additional figures and tables</p>
Abstract Diverse populations of bacteriophages infect and co-evolve with their bacterial hosts. Although host recognition infection occurs within microbiomes, the molecular mechanisms underlying host-phage interactions a community context remain poorly studied. The biofilms (rinds) aged cheeses contain taxonomically diverse microbial communities that follow reproducible growth patterns can be manipulated under laboratory conditions. In this study, we use cheese as model for studying...
Abstract Extensive evidence supports the role of immune system in modulating brain function and behaviour. However, past studies have revealed striking heterogeneity behavioural phenotypes produced from dysfunction. Using magnetic resonance imaging (MRI), we studied neuroanatomical differences among 11 distinct genetically-modified mouse lines (n=371), each deficient a different element system. We found significant heterogeneous effect dysfunction on brains both male female mice. by whole...
Abstract Background Autism Spectrum Disorder (ASD) and Congenital Heart Disease (CHD) are strongly linked on a functional genetic level. Most work has been focused neurodevelopmental abnormalities in CHD. Conversely, cardiac ASD have less studied. In this we investigate the prevalence of comorbidities relative to contributors ASD. Methods Using high frequency ultrasound imaging, screened 9 mouse models with ASD-related alterations ( Arid1b (+/-) , Chd8 16p11.2 (deletion), Sgsh (-/-) Shank3...