Signe Schuster Grasel

ORCID: 0000-0003-4060-6448
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About
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Research Areas
  • Hearing, Cochlea, Tinnitus, Genetics
  • Vestibular and auditory disorders
  • Hearing Loss and Rehabilitation
  • Noise Effects and Management
  • Ear Surgery and Otitis Media
  • Structural Health Monitoring Techniques
  • Ophthalmology and Eye Disorders
  • Scoliosis diagnosis and treatment
  • Sinusitis and nasal conditions
  • Genetics and Physical Performance
  • Balance, Gait, and Falls Prevention
  • Occupational exposure and asthma
  • Indoor Air Quality and Microbial Exposure
  • Cardiovascular Health and Disease Prevention
  • Salivary Gland Tumors Diagnosis and Treatment
  • Cerebral Venous Sinus Thrombosis
  • Spatial Neglect and Hemispheric Dysfunction
  • Sports Performance and Training
  • Oral and Maxillofacial Pathology
  • RNA regulation and disease
  • Reconstructive Facial Surgery Techniques
  • Dental Radiography and Imaging
  • Dermatological and COVID-19 studies
  • Congenital Ear and Nasal Anomalies
  • Shoulder Injury and Treatment

Universidade de São Paulo
2014-2021

Instituto Penido Burnier
2017

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2014

Universidade Estadual de Campinas (UNICAMP)
2014

OBJECTIVE: This study compared the results of caloric test with those video head impulse obtained during same session and evaluated whether former can be used to screen for non-acute vestibular dysfunction.METHODS: A total 157 participants complaining dizziness characteristics varying durations clinical courses completed test.RESULTS: Significantly more than were abnormal.CONCLUSIONS: The are distinct but complement each other.Within our sample, was sensitive dysfunction.Therefore, is not a...

10.6061/clinics/2017(08)03 article EN cc-by Clinics 2017-01-01

Conclusions. Elderly subjects without vestibular dysfunction had an overall worse performance as compared with the group of normal adults, confirming that age has a negative impact on balance. The elderly more important balance alterations than those without, major control in elderly. visual and systems presented functional changes ageing somatosensory system. Objective. main sensory input comes from visual, systems; all them may present due to ageing. This study aimed investigate...

10.1080/00016480802468930 article EN Acta Oto-Laryngologica 2009-01-01

Auditory steady-state responses (ASSR) are an important tool to detect objectively frequency-specific hearing thresholds. Pure-tone audiometry is the gold-standard for evaluation, although sometimes it may be inconclusive, especially in children and uncooperative adults. Compare pure tone thresholds (PT) with ASSR normal subjects. In this prospective cross-sectional study we included 26 adults (n = 52 ears) of both genders, without any complaints or otologic diseases pure-tone All subjects...

10.5935/1808-8694.20140009 article EN cc-by-nc-nd Brazilian Journal of Otorhinolaryngology 2014-01-01

Here we define a ~200 Kb genomic duplication in 2p14 as the genetic signature that segregates with postlingual progressive sensorineural autosomal dominant hearing loss (HL) 20 affected individuals from DFNA58 family, first reported 2009. The includes two entire genes, PLEK and CNRIP1, exon of PPP3R1 (protein coding), addition to four uncharacterized long non-coding (lnc) RNA genes part novel protein-coding gene. Quantitative analysis mRNA expression blood samples revealed selective...

10.1093/hmg/ddaa075 article EN Human Molecular Genetics 2020-04-22

Establish normative data for tympanic electrocochleography (TM ECochG) parameters in normal hearing adults without Ménière's disease's (MD) symptoms. Describe TM ECochG variables that help to distinguish from MD ears.We enrolled 100 subjects (N = 200 ears), 59 females, aged between 19 and 71 years 09/2010 04/2014. Inclusion criteria: otomicroscopy, thresholds ≤25 dB nHL 250 4000 Hz, tympanogram, no symptoms of according the AAO-HNS 1995 criteria Gibson's score <7. We excluded with dizziness,...

10.1016/j.joto.2017.04.005 article EN cc-by-nc-nd Journal of Otology 2017-05-13

Sudden hearing loss (SHL) is an ENT emergency defined as sensorineural (SNHL) ≥ 30 dB HL affecting at least 3 consecutive tonal frequencies, showing a sudden onset, and occurring within days. In cases of SHL, detailed investigation should be performed in order to determine the etiology provide best treatment. Otoacoustic emission (OAE) analysis, electronystagmography (ENG), bithermal caloric test (BCT), vestibular evoked myogenic potential (VEMP) assessments may used addition number...

10.7162/s1809-977720130003000011 article EN cc-by-nc-nd International Archives of Otorhinolaryngology 2013-06-28

Objective . To evaluate Auditory Steady-State Responses (ASSR) at high intensities in pediatric cochlear implant candidates and to compare the results behavioral tests responses. Methods This prospective study evaluated 42 children with suspected severe-to-profound hearing loss, aged from 3 72 months. All had absent ABR OAE ASSR were evoked using binaural single frequency stimuli 110 dB HL a 10 down-seeking procedure. test compared. Results Forty-two subjects completed both evaluation....

10.1155/2015/579206 article EN BioMed Research International 2015-01-01

Introduction The P3 cognitive evoked potential is recorded when a subject correctly identifies, evaluates and processes two different auditory stimuli. Objective to evaluate the latency amplitude of in 26 cochlear implant users with post-lingual deafness good or poor speech recognition scores as compared normal hearing subjects matched for age educational level. Methods In this prospective cohort study, cortical responses were from deaf adult (19 7 scores) control subjects. Results There was...

10.1055/s-0037-1613687 article EN cc-by-nc-nd International Archives of Otorhinolaryngology 2018-04-24

The correlations between behavioral and auditory steady-state response (ASSR) thresholds were significant at 500, 1000, 2000, 4000 Hz. ASSR presented high sensitivity specificity in the detection of residual hearing cochlear implant candidates when compared with warble-tone audiometry.To assess by comparing electrophysiological obtained dichotic single-frequency Hz.This was a comparative study audiometry 40 (80 ears) before implantation bilateral severe-to-profound sensorineural...

10.3109/00016489.2014.971463 article EN Acta Oto-Laryngologica 2015-02-04

This study aimed to evaluate if hearing performance is a predictor of postural control in cochlear implant (CI) users at least six months after surgery.Cross-sectional including recipients with post-lingual deafness and controls who were divided into the following groups: nine CI good (G+), five poor (G-), seven (CG). For each patient, computerized dynamic posturography (CDP) tests, sensory organization test (SOT), an adaptation (ADT) applied as dual task performance, first (FT) re-test (RT)...

10.1016/j.bjorl.2016.01.002 article EN cc-by Brazilian Journal of Otorhinolaryngology 2016-04-01

To assess potential alterations of the nasal mucosa by clinical and histopathological evaluation workers exposed to sulphuric acid mists at anodising plants, correlating findings with duration exposure concentrations in air, comparing them a control group.Fifty two from five plants underwent (standard questionnaire, clinical, ear, nose, throat examination including endoscopy). For study, 20 52 subjects (study group) were randomly selected, as well 11 unexposed (control group), matched sex,...

10.1136/oem.60.6.395 article EN Occupational and Environmental Medicine 2003-05-28

Background: Cochlear implantation (CI) is the gold standard therapy for profound or severe sensorineural hearing loss. It a safe surgical procedure but, because of proximity cochlea and vestibule, postoperative vestibular disorder may occur. Our hypothesis that video head impulse test (vHIT) be good tool to achieve topographic diagnosis dizziness in early period after CI.Aims/Objectives: To evaluate patients with instability, imbalance vertigo between 7 14 days CI procedure.Material methods:...

10.1080/00016489.2018.1535194 article EN Acta Oto-Laryngologica 2019-01-02

Vestibular recruitment is a sign of hyperexcitability central vestibular neurons and may be characteristic peripheral damage.To define the post-caloric index its ability to predict stage compensation lesion.First all, we demonstrated that larger values in cold stimulation compared warm were equivalent observed during sinusoidal harmonic acceleration test. In next step, patients with complaints asymptomatic controls submitted caloric We calculated for control group. Among study group,...

10.1016/j.bjorl.2021.04.006 article EN cc-by Brazilian Journal of Otorhinolaryngology 2021-05-07

Objective The aim of this study was to evaluate Auditory Steady‐State Responses (ASSR) at high intensities in pediatric cochlear implant candidates and compare the results behavioral test responses. Method This prospective evaluated 54 children with severe‐to‐profound hearing loss, aged from 3 72 months, between January December 2011. All had absent ABR OAE ASSR were evoked using binaural single frequency stimuli 110 dBHL a 10 dB‐down seeking procedure. compared. Results Forty‐two subjects...

10.1177/0194599812451438a204 article EN Otolaryngology 2012-08-01

Purpose This article combines the results of 3 studies that were presented at HeAL 2018 Conference in Lake Como, Italy, June 2018. Each study involved electrocochleography (ECochG), a neurodiagnostic evaluation has been used clinically for over 80 years but whose applications continue to expand. The 1st describes recent research wherein ECochG was recorded from asymptomatic subjects who siblings or offspring patients with confirmed diagnosis Ménière's disease (MD). Our provide evidence may...

10.1044/2019_aja-heal18-18-0190 article EN American Journal of Audiology 2019-10-16

OBJECTIVE: This is a cross-sectional epidemiological survey designed to estimate the prevalence of dizziness among adult population city Sa ˜o Paulo, Brazil, and describe clinical features level discomfort.METHOD: based study was conducted in between April October 2012.A total 1,960 household interviews were completed.The following variables assessed: gender, age, characteristics dizziness, disability index.Chi-square test, Student's t-test, Tukey test logistic regression used for...

10.5935/medicalexpress.2015.01.06 article EN Medical Express 2015-01-01

Objectives: In clinical practice, knowing the epidemiology of dizziness is essential. The aim study was to estimate prevalence among adult population city São Paulo, Brazil and describe features level discomfort. Methods: A cross‐sectional epidemiological survey conducted in between April October 2012. this field study, 1960 household interviews were completed. following variables assessed: sex, age, characteristics dizziness, disability index. Chi‐square test, Student t Tukey logistic...

10.1177/0194599814541627a168 article EN Otolaryngology 2014-09-01
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