A5102792458- Lipid Membrane Structure and Behavior
- Surfactants and Colloidal Systems
- Inflammatory mediators and NSAID effects
- DNA and Nucleic Acid Chemistry
- Photochemistry and Electron Transfer Studies
- Analytical Chemistry and Chromatography
- RNA and protein synthesis mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- X-ray Spectroscopy and Fluorescence Analysis
- RNA Interference and Gene Delivery
- Electron and X-Ray Spectroscopy Techniques
- Spectroscopy and Quantum Chemical Studies
- Drug Transport and Resistance Mechanisms
- Crystallography and molecular interactions
- Porphyrin and Phthalocyanine Chemistry
- Surface and Thin Film Phenomena
- Free Radicals and Antioxidants
- Receptor Mechanisms and Signaling
- Protein Structure and Dynamics
- Drug Solubulity and Delivery Systems
- Analytical Methods in Pharmaceuticals
- Ion-surface interactions and analysis
- Metal complexes synthesis and properties
- Radioactivity and Radon Measurements
- Enzyme Structure and Function
Saha Institute of Nuclear Physics
2010-2022
Barkatullah University
2002
Stockholm University
1996-2000
Karolinska Institutet
1997-2000
Institute of Molecular Biology
1997
Friedrich Schiller University Jena
1997
Chalmers University of Technology
1996
Istituto Centrale per la Ricerca Scientifica e Tecnologica Applicata al Mare
1987-1993
Peptide nucleic acid (PNA) is a DNA analogue in which the negatively charged sugar phosphate backbone has been substituted by uncharged N-(2-aminoethyl)glycine units. The study of PNA−DNA duplex and corresponding DNA−DNA gives unique opportunity to compare two polyelectrolytes with virtually identical geometry but greatly different linear charge density. results provide basis for applicability Poisson−Boltzmann (PB) counterion condensation (CC) theories. UV circular dichroism spectroscopy as...
Membrane fusion is a key event in many biological processes. These processes are controlled by various fusogenic agents of which proteins and peptides from the principal group. The process characterized three major steps, namely, inter membrane contact, lipid mixing forming intermediate step, pore opening finally inner contents cells/vesicles. steps governed energy barriers, need to be overcome complete fusion. Structural reorganization big molecules like proteins/peptides, supplies required...
If a vesicle is better model of membrane in the context hydrophobic effect, then from charge distribution point view, catanionic micelle closer to biomembrane. We have prepared and characterized two different types micelles sodium dodecyl sulfate (SDS) cetyl N,N,N-trimethylammonium bromide (CTAB) having surface ratios using optical spectroscopy transmission electron microscopy. The average size both mixed was found be much larger than that containing uniformly charged headgroups. Catanionic...
Abstract Spectroscopic and molecular modeling techniques have been employed to study the interaction of oxicam group nonsteroidal antiinflammatory drugs (NSAIDs) with a polysaccharide such as β‐cyclodextrin (β‐cd). β‐cd is good drug delivery system known reduce harmful side effects these in gastrointestinal tract increase their clinical efficacy. A detailed understanding host–guest helps designing better coupled increased therapeutic potential. However, there exists controversy which...
Membrane fusion is a critical step in many biological events. The process always induced by different fusogenic agents of which proteins and peptides form the largest group. mechanistic details vary depending on nature agents. However, membrane small drug molecules at physiologically relevant concentration has not been observed. Only recently our group shown that three painkillers, namely, meloxicam, piroxicam, tenoxicam, belonging to oxicam non-steroidal anti-inflammatory drugs (NSAIDs)...
Lornoxicam forms inclusion complexes with all cyclodextrins but for their hydroxy-propyl derivatives, the drug also interacts outer surfaces.
Membrane fusion is a key event in many biological processes. The process, both vivo and vitro, induced by different agents which include mainly proteins peptides. For protein- peptide-mediated membrane fusion, conformational reorganization serves as driving force. Small drug molecules do not share this advantage; hence, occurring absence of any other fusogenic agent at physiologically relevant concentration the drugs very rare event. To date, only three drugs, namely, meloxicam (Mx),...
The rigidity and flexibility of homologous psychrophilic (P), mesophilic (M), thermophilic (T) proteins have been investigated at the global local levels in terms "packing factors" "atomic fluctuations" obtained from B-factors. For comparison atomic fluctuations, correction errors by considering B-factors all sources a consolidated manner conversion fluctuations to same temperature suggested validated. results indicate no differences values like average packing factor among three classes...