A5101638938- Photochemistry and Electron Transfer Studies
- Protein Interaction Studies and Fluorescence Analysis
- Free Radicals and Antioxidants
- Spectroscopy and Quantum Chemical Studies
- Surfactants and Colloidal Systems
- Conducting polymers and applications
- DNA and Nucleic Acid Chemistry
- Analytical Chemistry and Chromatography
- Phytochemicals and Antioxidant Activities
- Drug Transport and Resistance Mechanisms
- Porphyrin and Phthalocyanine Chemistry
- Biopolymer Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Synthesis and Biological Evaluation
- Enzyme Structure and Function
- Luminescence and Fluorescent Materials
- Lipid Membrane Structure and Behavior
- Mechanical Behavior of Composites
- Fiber-reinforced polymer composites
- Synthesis and Characterization of Heterocyclic Compounds
- Organic Chemistry Cycloaddition Reactions
- Molecular spectroscopy and chirality
- Antioxidant Activity and Oxidative Stress
- Titanium Alloys Microstructure and Properties
University of Calcutta
2003-2022
Saha Institute of Nuclear Physics
2004-2013
Hindustan Aeronautics Limited (India)
1998
Florida State University
1979-1998
University of Michigan
1984-1987
Rajarshee Chhatrapati Shahu Maharaj Government Medical College and CPR Hospital Kolhapur
1935
Plant flavonoids are emerging as potent therapeutic drugs for free radical mediated diseases, which cell membranes generally serve targets lipid peroxidation and related deleterious effects. Screening characterization of these ubiquitous, therapeutically polyphenolic compounds, require a clear understanding regarding their incorporation possible location in membranes, well quantitative estimates antioxidative scavenging capacities. Here, we demonstrate the novel use intrinsic fluorescence...
Flavonols are plant pigments that ubiquitous in nature. Quercetin (3,3',4',5,7-pentahydroxyflavone) and other related flavonols have come into recent prominence because of their usefulness as anticancer, antitumor, anti-AIDS, important therapeutic activities significant potency low systemic toxicity. is intrinsically weakly fluorescent aqueous solution, showing an emission maximum at approximately 538 nm. Upon binding to human serum albumin (HSA), quercetin undergoes dramatic enhancement its...
Guanine-rich sequences have the propensity to fold into a four-stranded DNA structure known as G-quadruplex (G4). G4 forming are abundant in promoter region of several oncogenes and become key target for anticancer drug binding. Here we studied interactions two structurally similar dietary plant flavonoids fisetin naringenin with well double stranded (duplex) by using different spectroscopic modeling techniques. Our study demonstrates differential binding ability duplex DNA. Fisetin more...
Quadruplex (G4) forming sequences in telomeric DNA and c-myc promoter regions of human are associated with tumorogenesis. Ligands that can facilitate or stabilize the formation increase stabilization G4 prevent tumor cell proliferation have been regarded as potential anti-cancer drugs. In present study, steady state time-resolved fluorescence measurements provide important structural dynamical insights into free bound states therapeutically potent plant flavonoid fisetin...
The plant flavonoid quercetin (Que) binds more efficiently to VEGF G-quadruplex DNA (G4–DNA) compared double stranded as well other G4–DNAs.
Abstract The Raman and ir spectra of α‐helical poly( L ‐glutamic acid) have been assigned on the basis a normal mode calculation for this structure. force field was based our previously refined main‐chain constants α‐poly( ‐alanine) side‐chain β‐calcium–poly( ‐glutamate). Despite identical backbone structures, significantly different frequencies are calculated, observed, in amide III stretch regions acid), as compared with ‐alanine). This clearly demonstrates influence structure mainchain...
Excited-state intramolecular proton transfer (ESIPT) and dual luminescence behaviour of 3-hydroxyflavone (3-HF) have been utilized to monitor its binding liposomal membranes prepared from egg yolk phosphatydilcholine (EYPC). Additionally, absorption spectrophotometric assay has performed evaluate the antioxidant activity 3-HF against lipid peroxidation in this membrane system. When molecules are partitioned into EYPC liposomes, a weak long-wavelength band with lambda(abs)(max) approximately...