A5056376115- 3D Printing in Biomedical Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Gut microbiota and health
- Cancer Cells and Metastasis
- Inhalation and Respiratory Drug Delivery
- Cell Image Analysis Techniques
- Behavioral and Psychological Studies
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Pediatric health and respiratory diseases
- Workplace Health and Well-being
- Pneumonia and Respiratory Infections
- Hearing Loss and Rehabilitation
- Dermatology and Skin Diseases
- Antimicrobial Peptides and Activities
- Categorization, perception, and language
- Psoriasis: Treatment and Pathogenesis
- Latin American and Latino Studies
- Microfluidic and Capillary Electrophoresis Applications
- Respiratory Support and Mechanisms
- Diverse Educational Innovations Studies
- Immune Response and Inflammation
- Developmental and Educational Neuropsychology
- Criminal Justice and Corrections Analysis
- Tactile and Sensory Interactions
Draper Laboratory
2015-2023
Brewer Science (United States)
1975
University of Georgia
1975
Columbus State University
1975
Drug development suffers from a lack of predictive and human-relevant in vitro models. Organ-on-chip (OOC) technology provides advanced culture capabilities to generate physiologically appropriate, human-based tissue vitro, therefore providing route model. However, OOC technologies are often created at the expense throughput, industry-standard form factors, compatibility with state-of-the-art data collection tools. Here we present an platform supporting variety human models including liver,...
The drug development pipeline is severely limited by a lack of reliable tools for prediction human clinical safety and efficacy profiles compounds at the pre-clinical stage. Here we present design implementation platform technology comprising multiple cell-based tissue models in portable reconfigurable format that supports individual organ function crosstalk periods up to several weeks. Organ perfusion are enabled precision flow control based on electromagnetic actuators embedded an arrayed...
Influenza and other respiratory viruses present a significant threat to public health, national security, the world economy, can lead emergence of global pandemics such as from COVID-19. A barrier development effective therapeutics is absence robust predictive preclinical model, with most studies relying on combination in vitro screening immortalized cell lines low-throughput animal models. Here, we integrate human primary airway epithelial cells into custom-engineered 96-device platform...
Microphysiological organ-on-chip models offer the potential to improve prediction of drug safety and efficacy through recapitulation human physiological responses. The importance including multiple cell types within tissue has been well documented. However, study interactions in vitro can be limited by complexity model throughput current culture systems. Here, we describe development a co-culture microvascular relevant assays high-throughput thermoplastic platform, PREDICT96. system consists...
Respiratory viruses invade the upper airway of lung, triggering a potent immune response that often exacerbates preexisting conditions such as asthma and COPD. Poly(I:C) is synthetic analog viral dsRNA induces characteristic inflammatory associated with infection, loss epithelial integrity, increased production mucus cytokines. Here, we explore mechanistic responses to poly(I:C) in well-defined primary normal human bronchial (NHBE) model recapitulates vivo functions responses. We developed...
The skin microbiome plays a critical role at the interface between human epidermis and environment, providing colonization resistance against pathogenic strains, training host immunity, supporting epithelial turnover. Inversely, dysbiotic states are associated with disease, particularly inflammatory conditions such as atopic dermatitis psoriasis. Current evaluation of interactions relies on post hoc studies after disease onset. This limits ability to evaluate causal roles microbe during...
The intestinal epithelium comprises diverse cell types and executes many specialized functions as the primary interface between luminal contents internal organs. A key function provided by is maintenance of a barrier that protects individual from pathogens, irritating contents, microbiota. Disruption this can lead to inflammatory disease within mucosa, and, in more severe cases, sepsis. Animal models study permeability are costly not entirely predictive human biology. Here we present model...
COVID-19 emerged as a worldwide pandemic in early 2020, and while the rapid development of safe efficacious vaccines stands an extraordinary achievement, identification effective therapeutics has been less successful. This process limited part by lack human-relevant preclinical models compatible with therapeutic screening on native virus, which requires high-containment environment. Here, we report SARS-CoV-2 infection robust viral replication PREDICT96-ALI, high-throughput, human primary...
Multi-layer microfluidic oxygenator fabricated from three-dimensional branching blood flow networks mimicking physiological vasculature.
Abstract Despite the relatively common observation of therapeutic efficacy in discovery screens with immortalized cell lines, vast majority drug candidates do not reach clinical development. Candidates that move forward often fail to demonstrate when progressed from animal models humans. This dilemma highlights need for new screening technologies can parse early development regard predicted relevance use. PREDICT96-ALI is a high-throughput organ-on-chip platform incorporating human primary...
Abstract COVID-19 emerged as a worldwide pandemic early in 2020, and at this writing has caused over 170 million cases 3.7 deaths worldwide, almost 600,000 the United States. The rapid development of several safe highly efficacious vaccines stands one most extraordinary achievements modern medicine, but identification administration therapeutics to treat patients suffering from been far less successful. A major factor limiting progress effective treatments lack suitable preclinical models...
Abstract The COVID-19 pandemic necessitated a rapid mobilization of resources toward the development safe and efficacious vaccines therapeutics. Finding effective treatments to stem wave infected individuals needing hospitalization reduce risk adverse events was paramount. For scientists healthcare professionals addressing this challenge, need rapidly identify medical countermeasures became urgent, many compounds in clinical use for other indications were repurposed trials after preliminary...
Summary Fifth and sixth grade children were presented CCC trigram: digit pairs (e.g., XZF: 1) for either 2, 4, 6, or 10 paired-asociate (PA) trials. These Ss observed to have selected the first letters of trigrams after only 2 PA In addition, relative incidence single-letter selection (cue efficiency) decreased as degree learning increased. The important differences involved amount (p < .10) cue consistency. graders tended more single available they processed redundant in a consistent...
Abstract The intestinal epithelium comprises diverse cell types and executes many specialized functions as the primary interface between luminal contents internal organs. A key function provided by is maintenance of a barrier that protects individual from pathogens, irritating contents, microbiota. Disruption this can lead to inflammatory disease within mucosa, and, in more severe cases, sepsis. Animal models study permeability are costly not entirely predictive human biology. Here we...