Colline Wong
A5088729617- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- COVID-19 epidemiological studies
- Long-Term Effects of COVID-19
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- 3D Printing in Biomedical Research
- Zebrafish Biomedical Research Applications
- Single-cell and spatial transcriptomics
- Viral Infections and Outbreaks Research
- Psoriasis: Treatment and Pathogenesis
- HIV/AIDS Research and Interventions
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
Brigham and Women's Hospital
2017-2023
Harvard University
2017-2023
Draper Laboratory
2021
Harvard Stem Cell Institute
2017
Boston College
2017
Hospital de Especialidades
1997
Hospital General de México
1997
The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus 2019 (COVID-19). Here, we quantify from participants with a diverse range COVID-19 severity, including those requiring hospitalization, outpatients mild disease, individuals resolved infection. We detected plasma RNA 27% hospitalized participants, 13% diagnosed COVID-19. Amongst the COVID-19, report that higher prevalence detectable is associated worse respiratory lower...
Coronavirus disease 2019 (COVID-19) is associated with adverse outcomes, including need for invasive mechanical ventilation and death in people risk factors. Liver enzyme elevation commonly seen this group, but its clinical significance remains elusive. In study, we calculated the Fibrosis-4 (FIB-4) score a cohort of hospitalized patients COVID-19 assessed association severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA, inflammatory cytokine levels, outcome. A total 202...
Influenza and other respiratory viruses present a significant threat to public health, national security, the world economy, can lead emergence of global pandemics such as from COVID-19. A barrier development effective therapeutics is absence robust predictive preclinical model, with most studies relying on combination in vitro screening immortalized cell lines low-throughput animal models. Here, we integrate human primary airway epithelial cells into custom-engineered 96-device platform...
Abstract Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level on antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug resistance. Unraveling the mechanisms behind NSV would broaden our understanding persistence. Here we analyzed plasma virus sequences in eight ART-treated individuals with (88% male) and show that they are composed large clones viral evolution over time those longitudinal samples. We proviruses match RNA ‘producer...
Abstract The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus 2019 (COVID-19). We quantified from participants with a diverse range COVID-19 severity, including those requiring hospitalization, outpatients mild disease, individuals resolved infection. plasma RNA was detected 27% hospitalized 13% diagnosed COVID-19. Amongst the COVID-19, higher prevalence detectable associated worse respiratory lower absolute lymphocyte...
Early initiation of antiretroviral therapy (ART) alters viral rebound kinetics after analytic treatment interruption (ATI) and may play a role in promoting HIV-1 remission. Autologous neutralizing antibodies (aNAbs) represent key adaptive immune response people living with HIV-1. We aimed to investigate the aNAbs shaping post-ATI variants. performed single-genome amplification env from pre-ART plasma samples 12 individuals who initiated ART early infection. aNAb activity was quantified using...
<h3>INTRODUCTION</h3> An association between polymorphism of the HLA linked LMP2 locus and development acute anterior uveitis (AAU) has previously been described in B27 positive white subjects with ankylosing spondylitis (AS). This study evaluated alleles two HLA-B27 Mexican populations patients spondyloarthropathy known to have a different clinical spectrum disease from people. <h3>PATIENTS AND METHODS</h3> The consisted 90 AS Guadalajara predominantly adult onset 80 Mexico City juvenile...
ABSTRACT The relationship between SARS-CoV-2 viral load and risk of disease progression remains largely undefined in coronavirus 2019 (COVID-19). We quantified from participants with a diverse range COVID-19 severity, including those requiring hospitalization, outpatients mild disease, individuals resolved infection. plasma RNA was detected 27% hospitalized 13% diagnosed COVID-19. Amongst the COVID-19, higher prevalence detectable associated worse respiratory lower absolute lymphocyte...
Non-suppressible HIV-1 viremia (NSV) can occur in persons with HIV despite adherence to combination antiretroviral therapy (ART) and the absence of significant drug resistance. Here, we show that plasma NSV sequences are comprised primarily large clones without evidence viral evolution over time. We defined proviruses contribute as "producer", those did not "non-producer". Compared ART-suppressed individuals, participants had a significantly larger producer reservoir. Producer were enriched...