A5021513311- Computational Drug Discovery Methods
- Medicinal Plants and Neuroprotection
- Click Chemistry and Applications
- Natural Antidiabetic Agents Studies
- Phytochemistry and Biological Activities
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Heavy Metal Exposure and Toxicity
- Protein Tyrosine Phosphatases
- Diet, Metabolism, and Disease
- Chemical Synthesis and Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural product bioactivities and synthesis
- Advances in Cucurbitaceae Research
- Diverse Scientific Research Studies
- Advanced biosensing and bioanalysis techniques
- Garlic and Onion Studies
- Medicinal Plant Extracts Effects
- Neurological Disorders and Treatments
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Ginkgo biloba and Cashew Applications
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
Babcock University
2023-2024
University of Ilorin
2018-2024
University of Cambridge
2023
Afe Babalola University
2023
Multiple sclerosis is a demyelinating condition of the central nervous system which commonly affects young adults. Kolaviron, biflavonoid isolate Garcinia kola, has been used in experimental studies explored its anti-oxidative, anti-inflammatory and anti-genotoxic properties. This work was aimed at unraveling possible ameliorative effect kolaviron on cuprizone-induced demyelination prefrontal cortices Wistar rats. A total 28 adult male rats were divided into four groups A-D. Group received...
Spondias mombin is a prominent botanical resource and has garnered recognition within folkloric therapy. Parkinson's disease (PD), characterized by dopaminergic neuron attrition in the substantia nigra, manifests as motor anomalies like tremors, rigidity, bradykinesia. This study capitalizes on S. mombin's reservoir of 100 phytocompounds employs computational methodologies to interrogate their potential with 35 PD-associated target proteins. Employing multifaceted approach, we engaged...
Diabetes mellitus is a group of cardiometabolic disorders defined by elevated blood sugar levels. The majority people affected this disease reside in rural areas low- and middle-income countries. PTP1B inhibitory enzyme involved the control leptin insulin signaling. Cucumis sativus plant, which includes several phytochemical constituents, has been shown to have antidiabetic properties. This study examines silico potential bioactive compounds obtained from against potentially diabetogenic...
<title>Abstract</title> Clinical depression, a prevalent mental disorder, poses significant challenges worldwide, coupled with the adverse effects of its current pharmacotherapies. This study explores antidepressant potential <italic>Anacardium occidentale</italic>, plant known for pharmacological properties, aiming to offer safer, more effective alternative treating clinical depression. We conducted qualitative phytochemical screening <italic>A. occidentale</italic> leaves and assessed...
The phenotypic manifestation of lead toxicity includes cognitive, learning, and memory decline which is associated with neuronal injuries death been a major challenge in public health especially developing countries. Thus, we explore the prophylactic potentials luteolin prefrontal Pb intoxication. Thirty-six (36) male Wistar Rats were used for this research di-vided into six (6) groups animals each treated orally as follows: Group 1-Normal saline (0.5ml daily 14 days); 2- PbCl3 (50mg/kg 3-...
Abstract Background : Parkinson's Disease (PD) is a complex neurodegenerative disorder with elusive pathophysiological mechanisms. Recent studies have highlighted the role of genetic variations and metabolic changes in PD progression. Aim This study aims to investigate disparities PD, particularly focusing on LRRK2 mutations, analyze associated pathway alterations. Methodology The utilized R programming MetaIntegrator for meta-analysis ggplot2 visualization. Datasets underwent preprocessing,...
Abstract Background SARS-CoV-2, commonly known as the novel coronavirus or COVID-19, represents a highly contagious virus responsible for global pandemic. Its suspected origin in bats led to its first identification Wuhan, China, late 2019. Primarily transmitted through respiratory droplets from infected individuals coughing sneezing, manifests symptoms such fever, cough, and shortness of breath. Severe cases may escalate pneumonia failure. With death toll surpassing 6,937,771, urgent quest...
Abstract Introduction : Neuroinflammation plays a pivotal role in the development and progression of neurodegenerative diseases, with complex interplay between immune responses brain activity. Understanding this interaction is crucial for identifying therapeutic targets developing effective treatments. Aim: This study aimed to explore neuroprotective properties flavonoid compounds from Spondias mombin against neuroinflammation using comprehensive in-silico approach, including network...
Introduction: This study aimed at assessing the protective mechanisms of Kolaviron (KV) on cerebellum in a rat model demyelination. Methods: Twenty-eight male Wistar rats were used present study. They randomly divided into 4 groups 7 rats. Group A (control) received corn oil (0.5 mL/kg/d); group B 0.2% Cuprizone (CPZ); C was treated with 200 mg/kg/d KV, and D CPZ KV for 6 weeks. powder mixed regular diet while dissolved administered orally. behavioral test conducted termination experiment....
Abstract Spondias mombin ( S. ), a prominent botanical resource, has garnered recognition within folkloric therapy. Parkinson's disease (PD), characterized by dopaminergic neuron attrition in the substantia nigra, manifests as motor anomalies like tremors, rigidity, and bradykinesia. This study capitalizes on 's reservoir of 100 phytocompounds employs computational methodologies to interrogate their potential 35 PD-associated target proteins. Employing multifaceted approach, we engaged...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
In response to cancer research challenges, both in drug effectiveness and cost, discovery strategies have focused on novel compounds repurposing existing ones. This study seeks repurpose the affordable anabolic steroid nandrolone (ND) as a potential anticancer agent. Leveraging computer-aided design, assessed ND's binding scores (kcal/mol) inhibitory effects (IC50 µ/mol) against critical proteins (TOP2A, Cyclin D1, CDK4/6) cell lines (HEPG2, MHHNB11, SW1573, SNU245) using PyRx, Pymol,...
Objective: Tramadol and 3,4-methylenedioxy-methamphetamine (MDMA) use over an extended period is linked to deficits in memory encoding retrieval. We aimed determine the neurotoxic effects of co-administration MDMA tramadol (TRAM) on hippocampal function investigate potential FMRFamide attenuating resulting alterations Wistar rat model. Methods: Thirty adult male rats were grouped into six (n=5): Control, FMRFamide, TRAM, MDMA, TRAM+MDMA, TRAM + groups. The opiates administered orally at...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)