A5007417132- Bacterial Genetics and Biotechnology
- DNA Repair Mechanisms
- Enzyme Structure and Function
- Mosquito-borne diseases and control
- interferon and immune responses
- Endoplasmic Reticulum Stress and Disease
- Advanced Computing and Algorithms
- Viral Infections and Vectors
- Bacteriophages and microbial interactions
- Phytochemical compounds biological activities
- Synthesis and biological activity
- RNA modifications and cancer
- Antimicrobial Peptides and Activities
- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Photosynthetic Processes and Mechanisms
- Ubiquitin and proteasome pathways
- Genomics and Phylogenetic Studies
- Silymarin and Mushroom Poisoning
- Protist diversity and phylogeny
- Synthesis and Biological Evaluation
Centre National de la Recherche Scientifique
2013-2024
Université de Bretagne Occidentale
2013-2024
Ifremer
2013-2024
University of St Andrews
2022-2023
Institut de Biologie Structurale
2022
CEA Grenoble
2022
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2022
Université Grenoble Alpes
2022
Biology of Extremophiles Laboratory
2015
In Archaea, the proteins involved in genetic information processing pathways, including DNA replication, transcription, and translation, share strong similarities with those of eukaryotes. Characterizations components eukaryotic-type replication machinery complex provided many interesting insights into both domains. contrast, repair processes hyperthermophilic archaea are less well understood very little is known about intertwining between synthesis, recombination pathways. The development...
The mechanisms underpinning the replication of genomic DNA have recently been challenged in
Among the three domains of life, process homologous recombination (HR) plays a central role in repair double-strand DNA breaks and restart stalled replication forks. Curiously, main protein actors involved HR appear to be essential for hyperthermophilic Archaea raising interesting questions about strategies those living extreme conditions. One key actor this is recombinase RadA, which allows strand search provides substrate required following synthesis restoring genetic information....
Several archaeal species prevalent in extreme environments are particularly exposed to factors likely cause DNA damages. These include hyperthermophilic archaea (HA), living at temperatures >70°C, which arguably have efficient strategies and robust genome guardians repair damage threatening their integrity. In contrast Eukarya other archaea, homologous recombination appears be a vital pathway HA, the Mre11–Rad50 complex exerts broad influence on initiation of this response process. previous...
ABSTRACT Cyclic nucleotide signalling is a key component of anti-viral defence in all domains life, from bacteria to humans. Viral detection activates cyclase generate second messenger, resulting activation effector proteins. This exemplified by the metazoan cGAS-STING innate immunity pathway 1 , which originated 2 . These systems require sensor domain such as STING or SAVED bind cyclic nucleotide, coupled with an that causes cell death when activated destroying essential biomolecules 3 One...
The proteasome system allows the elimination of functional or structurally impaired proteins. This includes degradation nascent peptides. In Archaea, how complex interacts with translational machinery remains to be described. Here, we characterized a small orphan protein, Q9UZY3 (UniProt ID), conserved in Thermococcales. protein was identified native pull-down experiments using regulatory (proteasome-activating nucleotidase [PAN]) as bait. X-ray crystallography and small-angle scattering...