A5032571040- Heart Failure Treatment and Management
- Cancer Immunotherapy and Biomarkers
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Cardiovascular and exercise physiology
- Cardiac Arrhythmias and Treatments
- Nanoplatforms for cancer theranostics
- Cancer, Stress, Anesthesia, and Immune Response
- Radiomics and Machine Learning in Medical Imaging
- Cardiac electrophysiology and arrhythmias
- Fuel Cells and Related Materials
- Conducting polymers and applications
- Potassium and Related Disorders
- Cardiovascular Effects of Exercise
- 3D Printing in Biomedical Research
- HER2/EGFR in Cancer Research
- Ultrasound in Clinical Applications
- Chemokine receptors and signaling
- Biosimilars and Bioanalytical Methods
- Hemodynamic Monitoring and Therapy
- Medical Imaging Techniques and Applications
- Cytokine Signaling Pathways and Interactions
Swansea Bay University Health Board
2021-2024
Texas A&M University
2023-2024
Morriston Hospital
2021-2024
Georgia Institute of Technology
2022-2023
National Center on Addiction and Substance Abuse at Columbia University
2023
Hull York Medical School
2016-2022
University of Hull
2017-2022
Nirma University
2022
Reading Hospital
2022
Castle Hill Hospital
2016-2021
Abstract Aims Plasma concentrations of high-sensitivity C-reactive protein (hsCRP) are often raised in chronic heart failure (CHF) and might indicate inflammatory processes that could be a therapeutic target. We aimed to study the associations between hsCRP, mode cause death patients with CHF. Methods results enrolled 4423 referred clinic serving local population. CHF was defined as relevant symptoms or signs either reduced left ventricular ejection fraction <40% plasma amino-terminal...
Background Sacubitril/valsartan is an effective treatment for heart failure with reduced ejection fraction (HFrEF) based on clinical trial data. However, little known about its use or impact in real-world practice. The aim of this study was to describe our routine experience switching otherwise optimally treated patients HFrEF sacubitril/valsartan respect patient outcomes such as quality life (QoL) and echocardiographic variables. Methods results From June 2017 May 2019, 80 consecutive...
This study explores the effect of salt on diffusivity polyelectrolytes varied molecular architecture in layer-by-layer (LbL) films directions parallel and perpendicular to substrate using fluorescence recovery after photobleaching (FRAP) neutron reflectivity (NR) techniques, respectively. A family linear, 4-arm, 6-arm, 8-arm poly(methacrylic acids) (
Abstract Background Cachexia is common in patients with chronic heart failure and associated poor prognosis. How best to measure body composition not clear. Methods results We characterized 120 failure: mean (SD) age 70 (10) years, left ventricular ejection fraction 44 %, median (Q1–Q3) N‐terminal pro B‐type natriuretic peptide 845 (355–1368) ng/L. measured using dual‐energy X‐ray absorptiometry (DEXA) a multi‐frequency bioelectrical impedance analysis (BIA) device (Tanita BIA MC‐180MA)....
Despite the potential use of polyelectrolyte multilayers for biomedical, separation, and energy applications, their dynamic properties are not sufficiently understood. In this work, center-of-mass diffusion a weak polyacid-poly(methacrylic acid) (PMAA) linear 8-arm architecture (L-PMAA 8-PMAA, respectively) matched molecular weight-was studied in layer-by-layer (LbL) assemblies with poly(diallyldimethylammonium) chloride (PDADMAC) varied weight. The film deposition at low-salt, acidic...
Patients with chronic conditions, such as heart failure, swim regularly and most rehabilitation exercises are conducted in warm hydrotherapy pools. However, little is known about the acute effects of water immersion (WWI) on cardiac haemodynamics patients failure (CHF). Seventeen CHF (NYHA I II; mean age 67 years, 88% male, left ventricular ejection fraction 33%) 10 age-matched normal subjects were immersed up to neck a pool (33–35 °C). Cardiac measured non-invasively, echocardiography was...
Temporary cardiac pacing, conventionally achieved using a passive transvenous pacing wire, can be life-saving for unstable arrhythmias. However, they run the risk of complications, longer remain in-situ. Externalized prolonged temporary (EPTP), active-fixation lead and an externalized pulse generator; may alternative transient indications, concurrent illness or sepsis that precludes permanent pacing.Sixty-seven patients (mean age 69 ± 14 years; 82% male) underwent EPTP between November 2011...
We report associations between different formulae for estimating plasma volume status (PVS) and clinical ultrasound markers of congestion in patients with chronic heart failure (CHF) enrolled the Hull Lifelab registry.Cohort 1 comprised data on signs symptoms at initial evaluation (n = 3505). Cohort 2 included assessment [lung B-line count, inferior vena cava (IVC) diameter, jugular vein distensibility (JVD) ratio] (N 341). Two PVS were used: (a) Hakim (HPVS) (b) Duarte (DPVS). Results...
<h3>Introduction</h3> Despite optimal medical therapy (OMT), patients with HFrEF may remain symptomatic leading to increased hospitalisation or death. The European Society of Cardiology guidelines for heart failure recommend cardiac resynchronisation (CRT) and/or implantable defibrillators (ICD) in persisting left ventricular function impairment are despite therapy. We hypothesise that during complex device implant, right catheterization is feasible and could identify at higher risk...
The anion conductive ionomer in the oxygen-producing anode is a critical part of three-dimensional electrode exchange membrane alkaline electrolysis. In this study, self-adhesive ionomers were designed to chemical bond catalyst particles porous transport layer and ionomer. It was found that high ion capacity not needed for effective polarization because fed with electrolyte through flow channel. hydrophobic nature intimate contact by bonding key improving anodic cell durability. contents...
Abstract Introduction Digoxin is used in patients with chronic heart failure (CHF) who remain symptomatic despite optimal medical treatment. Impaired renal function commonly associated CHF. We investigated the relation between digoxin use and change over time Methods One thousand two hundred forty-one symptoms signs of CHF (average age 72 years (64% male), median NTproBNP 1426 ng/l (interquartile range 632–2897) were divided into four groups: never on ( N = 394); throughout 449); started at...
Revision to cardiac resynchronisation therapy (CRT) in patients with existing pacemakers worsening heart failure (HF) can improve symptoms and function. We identify factors that predict improvement left ventricular ejection fraction (LVEF) within a year of CRT revision.We performed retrospective study 146 consecutive (16% female, mean age 73 ± 11 years, LVEF 27 8%) undergoing revision (January 2012 May 2018) single tertiary centre. was measured pre-revision 3, 6 12 months post-upgrade.At...