A5101976939- Plant biochemistry and biosynthesis
- Plant Disease Resistance and Genetics
- Wheat and Barley Genetics and Pathology
- Fungal and yeast genetics research
- Plant Stress Responses and Tolerance
- Viral Infectious Diseases and Gene Expression in Insects
- Malaria Research and Control
- Evolution and Genetic Dynamics
- Muscle Physiology and Disorders
- Angiogenesis and VEGF in Cancer
- Biological and pharmacological studies of plants
- Plant pathogens and resistance mechanisms
- Microbial Natural Products and Biosynthesis
- Plant Genetic and Mutation Studies
- Pharmacological Effects of Natural Compounds
- Virology and Viral Diseases
- RNA Interference and Gene Delivery
- Peroxisome Proliferator-Activated Receptors
- vaccines and immunoinformatics approaches
- Inflammatory mediators and NSAID effects
- S100 Proteins and Annexins
- Plant and fungal interactions
- Plant Molecular Biology Research
- Leptospirosis research and findings
- Parasites and Host Interactions
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2023
Guangdong Provincial Hospital of Traditional Chinese Medicine
2022
Guangzhou University of Chinese Medicine
2022
Chengdu University of Traditional Chinese Medicine
2022
China Academy of Chinese Medical Sciences
2022
Guangxi Normal University
2022
Shandong University of Traditional Chinese Medicine
2022
Dali University
2022
Shandong Academy of Forestry
2014-2018
University of South China
2012-2016
Abstract Background We previously identified brain type fatty acid-binding protein (FABP7) as a prognostic marker for patients with glioblastoma (GBM). Increased expression of FABP7 is associated reduced survival. To investigate possible molecular mechanisms underlying this association, we compared the and subcellular localization in non-tumor tissues different types glioma, examined epidermal growth factor receptor (EGFR) GBM tumors. Methods Expression glioma specimens was using...
Soil alkalinity shows significant constraints to crop productivity; however, much less attention has been paid analyze the effect of soil on plant growth and development. Shanrong No. 4 (SR4) is an tolerant bread wheat cultivar selected from asymmetric somatic hybridization between Jinan 177 (JN177) tall wheatgrass (Thinopyrum ponticum), which a suitable material for studying associate genes. The SR4 seedlings was inhibited than that JN177 when exposed stress conditions. root cytosolic...
Soil salinity and/or alkalinity impose a major constraint over crop yield and quality. An understanding of the molecular basis plant response to these stresses could inform breeding more tolerant varieties. The bread wheat cultivar SR3 exhibits an enhanced level tolerance, while SR4 is distinguished by its superior tolerance alkalinity.The small RNA degradome sequencing was used explore miRNAs corresponding targets associated with stress SR lines. examination content two closely related...
Lipoxygenase (LOX) is a ubiquitous oxygenase found in animals and plants plays pivotal role diverse biological processes, including defense development. Artemisinin, which can only be obtained from Artemisia annua L., the most effective therapeutic drug for malaria without serious side effects. This study identified analyzed LOX gene family members A. genome at chromosomal level. Twenty genes with various molecular weights, isoelectric points, amino acid numbers were named AaLOX, located...
Abstract Background Amorpha-4,11-diene synthase (ADS) is a key enzyme in the artemisinin biosynthetic pathway. ADS promotes first step of synthesis by cyclizing faresyl pyrophosphate to synthesize sesquiterpene product amorpha-4,11-diene. Thanks continuous improvement genomic information, its evolutionary trace can be analyzed genome view. Methods Phylogenetic analysis was used identify -like genes other Asteraceae. Gene structure and motif analyze structural similarity these identified...
Gene therapy has emerged as a promising approach for the lethal disorder of Duchenne muscular dystrophy (DMD). Using novel non-viral delivery system, human ribosomal DNA (hrDNA) targeting vector, we targeted minidystrophin-GFP fusion gene into hrDNA locus HT1080 cells with high site-specific integrated efficiency 10(-5), in which transgene could express efficiently and continuously. The protein was easily found to localize on plasma membrane cells, indicating its possible physiologic...
Brassica napus is an important agricultural species, improving stress resistance was one of the main breeding goals at present. Non-specific lipid transfer proteins (nsLTPs) are small, basic which involved in some biotic or abiotic responses. B. susceptible to a variety fungal diseases, so identify BnLTPs and their expression disease responses very important. The common reference genome does not contain all genes because gene presence/absence variations between individuals. Therefore, it...
The aim of this study is to determine whether regulation the expression level fms-like tyrosine kinase-4 (Flt-4) related osteoclast differentiation.Osteoclast formation and differentiation mouse bone marrow cells RAW264.7 were performed. To induce differentiation, RANKL (50 ng/ml) with or without vascular endothelial growth factor-C (VEGF-C) factor-D (VEGF-D) was added cells. Then examined under a microscope. TRAP-positive 3 nuclei more considered as osteoclasts counted. Flt-4 gene knocked...
Schistosoma japonicum (S. japonicum) is an extremely harmful pathogen, which infects humans and causes severe public health problems. To date, no effective therapeutic drugs for this pathogen are available. In study, we designed constructed three hammerhead ribozymes targeting the eggshell protein gene of S. (SjESG). The cleavage activities these were determined using experiments. in vitro results showed that among synthesized (Rz1, Rz2 Rz3), Rz1 Rz3 cleaved their target RNAs effectively....
Abstract Artemisia annua produces a mass of artemisinin, an effective drug widely used in malaria treatment. The AP2 transcription factors family which is one the largest families higher plants plays significant roles growth and development regulating plant secondary metabolites tolerances to environmental stresses. However, available data on contributions gene whole genome annu limited. In this study, 195 genes were identified compared with from Arabidopsis thaliana . These A. classified...