A5077943745- CAR-T cell therapy research
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Kawasaki Disease and Coronary Complications
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
- Alcoholism and Thiamine Deficiency
- Airway Management and Intubation Techniques
- Infectious Encephalopathies and Encephalitis
- Case Reports on Hematomas
- Cancer Immunotherapy and Biomarkers
- Muscle and Compartmental Disorders
- Lymphoma Diagnosis and Treatment
- Infant Development and Preterm Care
- Immunotherapy and Immune Responses
- Neonatal Respiratory Health Research
- Biomedical and Engineering Education
- Viral-associated cancers and disorders
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Polyomavirus and related diseases
- Neurological and metabolic disorders
George Washington University
2023-2025
Children's National
2021-2024
University of Southern California
2024
Kapiolani Medical Center for Women and Children
2018
University of Hawaii System
2018
University College Cork
2017
Immunocompromised patients, including those with inborn errors of immunity (IEI), may be at increased risk for severe or prolonged infections SARS-CoV-2 (Zhu et al. N Engl J Med. 382:727–33, 2020; Guan Minotti Infect. 81:e61–6, 2020). While antibody and T cell responses to structural proteins are well described in healthy convalescent donors, adaptive humoral cellular has not yet been characterized patients deficiency (Grifoni Cell. 181:1489–1501 e1415, Burbelo Long Nat 26:845–8, Braun...
Patients with hematologic malignancies relapsing after allogeneic blood or marrow transplantation (BMT) have limited response to conventional salvage therapies, an expected 1-year overall survival (OS) of <20%. We evaluated the safety and clinical outcomes following administration a novel T-cell therapeutic targeting 3 tumor-associated antigens (TAA-T) in patients acute leukemia who relapsed were at high risk relapse BMT. Lymphocytes obtained from BMT donor manufactured target TAAs WT1,...
Abstract Posttransplant lymphoproliferative disease (PTLD) in pediatric solid organ transplant (SOT) recipients is characterized by uncontrolled proliferation of Epstein-Barr virus–infected (EBV+) B cells due to decreased immune function. This study evaluated the feasibility, safety, clinical and immunobiological outcomes SOT with PTLD treated rituximab third-party latent membrane protein–specific T (LMP-TCs). Newly diagnosed (ND) patients without complete response all relapsed/refractory...
Background Despite similar rates of infection, adults and children have markedly different morbidity mortality related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Compared adults, infrequent manifestations infection but are uniquely at risk for the rare often Multisystem Inflammatory Syndrome in Children (MIS-C) following infection. We hypothesized that these differences presentation magnitude and/or antigen specificity SARS-CoV-2-specific T cell (CST) responses between...
Placement of endotracheal tubes (ETTs) and umbilical catheters (UCs) is essential in very preterm infant care. The aim this study was to assess the effect an educational initiative optimize correct placement ETTs UCs infants. A pre-post design, evaluating optimal radiological position first 72 h life infants <32 weeks gestational age (GA) performed. Baseline data obtained from a preceding 34-month period. intervention consisted information pre-intervention audit, surface anatomy images...
Hematopoietic stem cell transplantation (HSCT) is being increasingly used as a curative approach for sickle disease (SCD). With the risk of graft-versus-host (GVHD), especially in human leukocyte antigen-mismatched donors, intense immunosuppression required leading to an increased viral infection. Post-HSCT, adoptive transfer virus-specific T-cell (VST) therapies have not been well-studied patients with SCD. Here, we report outcomes SCD at single-center who received VSTs after transplant...
Central pontine myelinolysis (CPM) is rarely reported in pediatric patients with diabetic ketoacidosis (DKA). We report this case of a 16-year-old female new onset diabetes presenting DKA, who received aggressive fluid resuscitation and sodium bicarbonate the emergency department. Later she developed altered mental status concerning for cerebral edema hyperosmolar therapy only transient improvement. Soon became apneic requiring emergent endotracheal intubation. MRI brain showed edema, CPM,...
Kinoshita, Hannah1; Ching, Stefanie1; Vita, Jan1; Purohit, Prashant1 Author Information
Johnson, Scarlett1; Kinoshita, Hannah2; Wu, Brian1; Kyono, Wade2; Fong, Edward1; Reddy, Venu2; Purohit, Prashant2 Author Information
Kinoshita, Hannah1; Johnson, Scarlett1; Glaser, Darryl1; Ingraham, Susan1; Purohit, Prashant1 Author Information
Graziani, Stephanie1; Kinoshita, Hannah1; Johnson, Scarlett2; Glaser, Darryl1; Melish, Marian1; Purohit, Prashant1 Author Information
Background: Despite similar rates of infection, adults and children have markedly different morbidity mortality related to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Compared adults, infrequent manifestations infection but are uniquely at risk for the rare often Multisystem Inflammatory Syndrome in Children (MIS-C) following infection. The cause these differences presentation may relate host response between children. We thus set out measure SARS-CoV-2-specific T cell...