Jiahao Chen

ORCID: 0000-0003-4110-2049
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About
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Research Areas
  • Acute Ischemic Stroke Management
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Parkinson's Disease Mechanisms and Treatments
  • Bone Metabolism and Diseases
  • Bone health and treatments
  • Bone health and osteoporosis research
  • Cardiovascular and Diving-Related Complications
  • Neuroscience and Neuropharmacology Research
  • Barrier Structure and Function Studies
  • Blood properties and coagulation
  • Biochemical Analysis and Sensing Techniques
  • Ginkgo biloba and Cashew Applications
  • Sleep and related disorders
  • Cerebral Venous Sinus Thrombosis
  • Connexins and lens biology
  • Cerebrovascular and Carotid Artery Diseases
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Vestibular and auditory disorders
  • Neurological Disease Mechanisms and Treatments
  • Circadian rhythm and melatonin
  • Trauma, Hemostasis, Coagulopathy, Resuscitation
  • Restless Legs Syndrome Research
  • High Altitude and Hypoxia

Zhejiang Chinese Medical University
2025

Capital Medical University
2022-2025

First Affiliated Hospital of Wenzhou Medical University
2024

Wenzhou Medical University
2024

Normobaric hyperoxia (NBO) has neuroprotective effects in acute ischemic stroke. Thus, we aimed to identify the optimal NBO treatment duration combined with endovascular treatment.

10.1161/strokeaha.123.046106 article EN Stroke 2024-05-15

This study aimed to analyse the relationship of blood lipid profile and interleukin-6 (IL-6) with osteoporosis osteopenia explore predictive value combined application these biomarkers in osteopenia. Data from 276 patients treated orthopaedics department were retrospectively analysed. Their general information was collected, relationships among profile, IL-6 bone turnover markers, mineral density (BMD) Patients categorized based on their T scores for intergroup comparisons. Finally,...

10.1186/s12944-025-02456-2 article EN cc-by-nc-nd Lipids in Health and Disease 2025-02-05

Our research aims to explore the effect of salmon calcitonin (sCT) combined with three calcium antagonists (CCA), verapamil, nifedipine and diltiazem, on phosphorus ion metabolism in blood osteoporotic female rats following ovarian removal. To a method combination medication suitable for postmenopausal women osteoporosis. We first carried out drug experiment rats, then osteoporosis rats. Blood samples were collected at 1, 2, 4, 8 12 h post-administration, we measured concentration ions...

10.1186/s40001-025-02384-y article EN cc-by-nc-nd European journal of medical research 2025-02-18

Hemorrhagic transformation (HT) is a serious complication that can occur spontaneously after an acute ischemic stroke (AIS) or thrombolytic/mechanical thrombectomy. Our study aims to explore the potential correlations between fibrinogen levels and occurrence of spontaneous HT (sHT) mechanical thrombectomy (tHT).

10.3389/fneur.2024.1364875 article EN cc-by Frontiers in Neurology 2024-07-25

Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in substantia nigra (SN) pars compacta. Dopamine (DA) replacement therapy one most effective drug treatments for PD; however, long-term levodopa treatment can lead to various side effects that negatively impact quality life patients. Therefore, finding safe and alternative drugs treat PD clinical importance. The Bushen-Jianpi decoction (BSJPD) was derived from classic...

10.1155/2022/9191284 article EN Evidence-based Complementary and Alternative Medicine 2022-11-18

BACKGROUND Recent advancements in animal studies have demonstrated the potential of normobaric hyperoxia (NBO) as a promising intervention for preserving integrity blood–brain barrier (BBB). However, there is still limited understanding effects NBO on BBB function patients with clinical stroke. Therefore, objective this study was to investigate efficacy therapy attenuating damage and reducing brain injury individuals undergoing endovascular treatment (EVT) acute METHODS AND RESULTS This...

10.1161/jaha.124.036474 article EN cc-by-nc-nd Journal of the American Heart Association 2024-10-18

This study explored the association between insomnia and clinical outcome of large vessel occlusion Acute Ischemic Stroke (AIS) attempted to explore its potential mechanisms from perspectives inflammation oxidative stress.AIS patients who underwent endovascular treatment for at Binzhou Central Hospital 2018 2022 (n = 508) were included. Patients divided into an group a non-insomnia group. Insomnia was judged by self-reported Athens Scale score. Regression analysis used compare differences in...

10.1016/j.clinsp.2023.100297 article EN cc-by Clinics 2023-01-01

Abstract BACKGROUND Normobaric hyperoxia (NBO) has neuroprotective effects in acute ischemic stroke (AIS). Thus, we aimed to identify the optimal NBO treatment duration combined with endovascular (EVT). METHODS Patients who had an indication for EVT at Tianjin Huanhu Hospital were included and randomly assigned four groups (1:1 ratio) based on therapy duration: 1) Sham-NBO group (oxygen 1 L/min continuously 4 h); 2) NBO-2h (10 2 3) NBO-4h 4) NBO-6h 6 h). The primary outcome was cerebral...

10.1101/2023.12.05.23299563 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-12-07
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