A5101567947- Neurological Disease Mechanisms and Treatments
- Stroke Rehabilitation and Recovery
- Microbial infections and disease research
- Mosquito-borne diseases and control
- Cardiac Arrhythmias and Treatments
- Animal Virus Infections Studies
- Traditional Chinese Medicine Studies
- Atrial Fibrillation Management and Outcomes
- Neuroinflammation and Neurodegeneration Mechanisms
- Fungal Biology and Applications
- Cardiac electrophysiology and arrhythmias
- Alzheimer's disease research and treatments
- Aquaculture disease management and microbiota
- Organ Donation and Transplantation
- Intracerebral and Subarachnoid Hemorrhage Research
- Viral Infections and Vectors
- Acute Ischemic Stroke Management
- Organ Transplantation Techniques and Outcomes
- Traditional Chinese Medicine Analysis
- Advanced Glycation End Products research
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Aldose Reductase and Taurine
- Animal Disease Management and Epidemiology
- Heme Oxygenase-1 and Carbon Monoxide
Ministry of Agriculture and Rural Affairs
2023-2025
Sichuan Agricultural University
2009-2025
Southern Medical University
2015-2025
Nanfang Hospital
2016-2025
Science and Technology Department of Sichuan Province
2025
University of Electronic Science and Technology of China
2017-2022
Capital Medical University
2008-2022
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
2022
Sixth Affiliated Hospital of Sun Yat-sen University
2022
Sun Yat-sen University
2022
Ginsenoside 20(S)-Rh2 has been shown to induce apoptosis and differentiation of acute myeloid leukemia (AML) cells. However, the underlying molecular mechanisms are not fully understood. In our study, induced expression orphan nuclear receptor Nur77 death proteins Fas, FasL, DR5, TRAIL, as well cleavage caspase 8 3 in HL-60 Importantly, shNur77 attenuated 20(S)-Rh2-induced Fas DR5 expression. Meanwhile, promoted translocation from nucleus mitochondria enhanced interaction between Bcl-2,...
Pasteurella multocida, a zoonotic pathogen that produces 146-kDa modular toxin (PMT), causes progressive atrophic rhinitis with severe turbinate bone degradation in pigs. However, its mechanism of cytotoxicity remains unclear. In this study, we expressed PMT, purified it prokaryotic expression system, and found killed PK15 cells. The host factor CXCL8 was significantly upregulated among the differentially genes transcriptome sequencing analysis qPCR verification. We constructed...
After being discovered for the first time in China 2017, porcine reproductive and respiratory syndrome virus (PRRSV) NADC34-like strains have become prevalent strain of PRRSV certain regions China. Our previous study showed that reduced Ingelvac PRRS MLV vaccination dosages against NADC30-like CF had a better protection effect than normal dosage. However, protective is unclear. Therefore, this compared effectiveness 0.1 1 infection using commercial vaccines, MLV, which been widely utilized...
Moderate-to-severe asthma has a substantial impact on the health-related quality of life (HR-QOL) patients. Cordyceps sinensis is traditional Chinese medicine that evaluated clinically for treatment many diseases, such as chronic allograft nephropathy, diabetic kidney disease, and lung fibrosis. In order to investigate effects patients with moderate-to-severe persistent asthma, 120 subjects were randomized receive Corbin capsule containing 3 months (treatment group, n = 60), whereas control...
BACKGROUND: Tenuigenin (TEN), a major active component of the Chinese herb Polygala tenuifolia root, has been used to improve memory and cognitive function in Traditional Medicine for centuries. PURPOSE: The present study was designed explore possible neuroprotective effect TEN on streptozotocin (STZ)-induced rat model sporadic Alzheimer's disease (sAD). METHODS: STZ injected twice intracerebroventrically (3 mg/kg, ICV) alternate days (day 1 day 3) Rats. Daily treatment with (2, 4, 8 mg/kg)...
Beta-asarone (β-Asarone), the major component of Acorus tatarinowii Rhizoma, has been proved to be muti-pharmacological activities including anti-inflammation, and which is effective in protecting central nervous system. However, effect β-Asarone on myocardial ischemia–reperfusion (I/R) injury not yet clear. This study used a rat model with 45 min occlusion 24 h releasing proximal segment left anterior descending coronary artery. The effects cardiac histopathology, infarction size, levels...
Pulmonary vein isolation (PVI) using conventional power (30–35 W) radiofrequency ablation (RFA) has been an effective treatment strategy for paroxysmal atrial fibrillation (PAF), but its longer duration may cause collateral damage to peripheral tissue including esophageal and phrenic nerve. High-power (HP) RFA, due better transmural performance shorter duration, reduce the adjacent is expected be a safe efficient strategy. In this retrospective cohort study, we included 259 patients with PAF...
Left ventricular (LV) dysfunction is closely associated with LV hypertrophy or diabetes, as well insufficient autophagic flux. Acute chronic hyperglycemia a prognostic factor for patients myocardial infarction. However, the effect of acute on hypertrophic heart and mechanisms involved are still unclear. This study aimed to confirm our hypothesis that either suppresses diastolic function The transverse aortic constriction (TAC) model streptozocin-induced type 1 diabetic mellitus mice were...
Japanese encephalitis virus (JEV) is a mosquito-borne, zoonotic flavivirus causing viral in humans and reproductive disorder swine. JEV prevalent throughout China human; however, spatiotemporal analysis of Chinese swine herds has not been reported previously. Herein, we present serological molecular epidemiological results estimates prevalence infections among various regions China. The suggest that are widespread genotype I III strains co-exist the same regions. Therefore, there an urgent...
Abstract Glaesserella parasuis is usually a benign swine commensal in the upper respiratory tract, but virulent strains can cause systemic infection characterized by pneumonia, meningitis, and fibrinous polyserositis. The intensive pulmonary inflammatory response following G. main of lung injury death pigs. Vaccination has failed to control disease due lack extended cross-protection. Accumulating evidence indicates that heme-binding protein A (HbpA) potential virulence determinant promising...
Although the Japanese encephalitis virus (JEV) infects various cell types, its receptor molecules are still not clearly understood. In our laboratory’s prior research, Rab4b was identified as a potential host factor that facilitates JEV infection in PK15 cells, utilizing genome-wide CRISPR/Cas9 knockout library (PK-15-GeCKO). To further explore effect of on replication, we used line using technology and overexpressing line, with IFA, RT–qPCR, Western blot to study viral replication whole...
Glaesserella parasuis cytolethal distending toxin (GpCDT) can induce cell cycle arrest and apoptosis. Our laboratory’s previous work demonstrated that GTPase 4b (Rab4b) is a key host protein implicated in GpCDT-induced cytotoxicity. This study investigated the probable involvement of Rab4b process. used CRISPR/Cas9 technology to create Rab4b-knockout line. The results showed greater resistance In contrast, forced overexpression increased Further immunoprecipitation reveals GpCDT may bind...
Background: Swallowing apraxia is characterized by impaired volitional swallowing but relatively preserved reflexive swallowing. Few studies are available on the effectiveness of behavioral therapy and management condition.Objective: This study aimed to investigate effect transcranial direct current stimulation (tDCS) cortical activation in stroke patients.Methods: The included three inpatients (age 48–70 years; 1 male, 2 females; duration stroke, 35–55 d) with post-stroke six age-matched...
Background: Learning and memory impairments are important indexes in assessing Alzheimer's disease (AD). Lonicera japonica (L. japonica), a traditional Chinese herbal medicine, inhibits inflammation, but its role neuroprotection is unclear. Polysaccharide the main active ingredient L. japonica. Here, we aimed to validate effects of polysaccharide (LJP) on lipopolysaccharide (LPS)-induced cognitive impairment underlying mechanism. Methods: The medicine system pharmacology database analysis...