A5040621121- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Schizophrenia research and treatment
- Nerve injury and regeneration
- Psychosomatic Disorders and Their Treatments
- Personality Disorders and Psychopathology
- Autism Spectrum Disorder Research
- Suicide and Self-Harm Studies
- Pharmacological Effects of Natural Compounds
- Mental Health and Psychiatry
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Medicinal Plants and Bioactive Compounds
- Obsessive-Compulsive Spectrum Disorders
- Plant tissue culture and regeneration
- Psychological Treatments and Assessments
- Venomous Animal Envenomation and Studies
- Myofascial pain diagnosis and treatment
- Neuroscience and Neuropharmacology Research
- Ziziphus Jujuba Studies and Applications
- Pain Management and Treatment
- Cannabis and Cannabinoid Research
- Medicinal Plant Extracts Effects
- CRISPR and Genetic Engineering
University of Zielona Góra
2020-2025
Poznan University of Medical Sciences
2015-2024
University of Life Sciences in Poznań
2024
Center for Children
2021
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2019
Background/Objectives: The incidence of mood disorders in adolescents is increasing. Bipolar disorder often misdiagnosed the early stages disease due to prevalence depressive symptoms, while manic episodes occur later. Identifying predictors diagnosis conversion could facilitate timely and appropriate treatment. Our study aimed find correlations selected peripheral protein levels with temperament character traits diagnosed major bipolar disorder. Methods: A group young adults (MDD, n = 50)...
Formal Thought Disorder (FTD) is a significant clinical feature of early-onset psychosis, often associated with poorer outcomes. Current diagnostic methods rely on assessment, which can be subjective and time-consuming. This study aimed to investigate the potential neuropsychological tests machine learning differentiate individuals without FTD. A cohort 27 young people psychosis was included. Participants underwent assessment using Iowa Gambling Task (IGT) Simple Reaction Time (SRT) tasks....
Abstract Aim Schizophrenia onset in the developmental age has a strong neurodevelopmental burden and is associated with poorer prognosis. The approach to diagnosis still based on symptomatic description without objective validation. In this study, we aimed compare peripheral blood levels of hypothesized biomarker proteins: brain‐derived neurotrophic factor (BDNF), proBDNF, p75 neurotrophin receptor (p75 NTR ) S100B between early‐onset schizophrenia‐spectrum adolescents ( n = 45) healthy...
The accurate assessment of suicide risk in psychiatric, especially affective disorder diagnosed patients, remains a crucial clinical need. In this study, we applied temperament and character inventory (TCI), Barratt impulsiveness scale 11 (BIS-11), PEBL simple reaction time (SRT) test, continuous performance task (CPT), Iowa gambling (IGT) to seek for variables linked with attempted bipolar group ( n = 60; attempters 17). main findings were: strong correlations between self-report tool...
Lithium has been the most important mood stabilizer used for treatment of bipolar disorder and prophylaxis manic depressive episodes. Despite long use in clinical practice, exact molecular mechanisms lithium are still not well identified. Previous experimental studies produced inconsistent results due to different duration using animals without manic-like or depressive-like symptoms. Therefore, we aimed analyze gene expression profile three brain regions (amygdala, frontal cortex...
In mood disorders chronic stress contributes to decreased glucocorticoid receptor signalling in the brain and resistance periphery. We hypothesised that aberrant function may result from genetic predisposition GR correlates with expression of genes regulating complex formation.We performed association analysis 698 patients: 490 patients bipolar disorder 208 major depressive 564 control subjects. genotyped 11 variants using TaqMan assays. Gene tissue was done male Wistar rats after mild...
Due to current depression prevalence, it is crucial make the correct diagnosis as soon possible. The study aimed identify commonly available, easy apply, and quick interpret tools allowing for a differential between unipolar bipolar disorder. group includes women with long duration of (UP, N = 34) (BP, 43) affective was established according DSM criteria using SCID questionnaire. Additional questionnaires were used differentiate UP BP. BP patients had an earlier age onset, hospitalized more...
Summary Introduction: Rhodiola rosea (RR) and kirilowii (RK) are well known for their influence on central nervous system, however impact the development of alcohol tolerance has not yet been proven. Objective: The aim this study was to determine ability RR RK roots extracts inhibit in vivo , both, peripheral (metabolic) ones. Methods: Male Wistar rats were treated with ( p.o. ) ethanol i.p. ten consecutive days. On first, third, fifth eighth days hypothermic action measured, while ninth day...
(1) Background: Schizophrenia is a chronic and progressive neuropsychiatric illness. Apart from positive negative symptoms, 98% of the population diagnosed with schizophrenia have impaired cognitive functioning, which significantly influences quality life. The correlation between lipids functioning has been well established. Our study aimed to investigate correlations functions, severity lipid profiles. (2) Methods: Fifty-two women participated in this study. Cognitive was measured using...
Introduction Impulsivity is the tendency to take quick and rash actions without ability assess their consequences, resulting in an increased frequency of risky behaviors. In recent years, it has been indicated that impulsivity a multidimensional construct with different ways expression various mental illnesses. Moreover, personality traits might predispose do psychiatric diagnoses impact its course. Objectives Because differences manifestation can be observed at several levels (e.g.,...
Introduction Introduction: Affective patients, especially depressive, have an increased risk of suicidal behavior. Identifying individuals at remains a challenge. Among the correlates that may be crucial, impact personality is emphasized. Attention paid to impulsivity, measured by subjective or objective tests. Objectives Objectives: Comparative analyses were carried out capture differences and relationship between dimensions, decision-making style coping with stress strategies in suicide...
Background: Impulsivity assessment may serve as a valuable clinical tool in the stratification of suicide risk. Acting without forethought is crucial feature psychopathology many psychiatric disturbances and corresponds with suicidal ideations, behaviors, attempts. Methods: We present data on biological psychological correlates impulsivity among young adults (n = 47). Psychological analysis included both self-description questionnaire—Barratt Impulsiveness Scale (BIS-11)—and...
The growing awareness and need to protect public health, including food safety, require a thorough study of the mechanism action veterinary drugs in consumers reduce their negative impact on humans. Inappropriate use animal husbandry, such as tiamulin, leads appearance residues edible tissues. natural substances plant origin, extracted from hemp (Cannabis sativa L.), cannabidiol (CBD), is one solutions minimize effects tiamulin. This aimed determine effect CBD cytotoxicity tiamulin cytotoxic...
The aim of this study was to examine the ability extracts from root Rhodiola rosea (RR) and kirilowii (RK) inhibit development acute ethanol tolerance. ethanol-water (1:1) were standardized on phenylpropanoids (rosavin, rosin, rosarin) phenylethanoids (salidroside, p-tyrosol) contents. experiments performed …
A recent view on schizophrenia phenomenology underlines the impaired relations between mind and body. An aberrant feeling of ipseity may be real source suffering patients from psychosis impacts general symptomatology. The disturbed connection thinking processes environmental stimuli lead to language disembodiment. In study, we aimed experimentally test presence disembodied investigate its association with symptoms in adolescents diagnosed early-onset spectrum disorders. Assessment embodiment...
Lithium is a mood stabilizer widely used in the pharmacotherapy of bipolar disorder and treatment‑resistant depression. Taking into account dysregulated inflammatory activity depression immunomodulatory role lithium, we hypothesized that genes associated with responses may be potential biomarkers lithium action. We aimed to compare gene expression changes between brain periphery after chronic administration an animal model Depressive behavior was induced by mild stress protocol for 4 weeks....
Current development of neurosciences seems to leave psychopathology out the way. In comparison with other branches medicine, psychiatry still discusses point terms, coined describe mental phenomenology in past. Such situation resembles status quo medieval scholastics, where dialectic methods aiming explain nature were insufficient. this brief report, author would like present currently used psychiatric vocabulary from Baconian view. Using examples different idols, aimed semantic and...
Alcoholism is a severe social and medical problem. Inadequate ethanol (EtOH) consumption results in acute chronic conditions, which lead to many hospitalizations generate considerable costs healthcare. undoubtedly needs be thoroughly described, especially relation the molecular mechanism of addiction. The current opinion about pathogenesis EtOH abuse mainly based on dopaminergic theory addiction, connected with impaired function transmission brain’s reward system. Moreover, recent evidence...