A5047516625- Neural Networks and Applications
- Pharmacological Effects of Natural Compounds
- Phytochemistry and Biological Activities
- Phytochemicals and Antioxidant Activities
- Medicinal Plants and Neuroprotection
- Medicinal Plants and Bioactive Compounds
- Regulation of Appetite and Obesity
- Cholinesterase and Neurodegenerative Diseases
- Cannabis and Cannabinoid Research
- Biochemical effects in animals
- Advanced Memory and Neural Computing
- Phytoestrogen effects and research
- Traditional Chinese Medicine Analysis
- Pain Management and Opioid Use
- Pregnancy and preeclampsia studies
- Pain Mechanisms and Treatments
- Biochemical Analysis and Sensing Techniques
- Sensor Technology and Measurement Systems
- Pomegranate: compositions and health benefits
- Natural product bioactivities and synthesis
- Gaze Tracking and Assistive Technology
- Curcumin's Biomedical Applications
- Medicinal Plant Extracts Effects
- Ginkgo biloba and Cashew Applications
- Parkinson's Disease Mechanisms and Treatments
Poznan University of Medical Sciences
2016-2025
Shantou University
2018
Poznań University of Technology
2003-2014
University of Life Sciences in Poznań
2014
Celiko (Poland)
2012
Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute wide range pomegranate's health benefits. While lot experimental studies have been devoted Alzheimer disease and hypoxic-ischemic brain injury, our knowledge effects against Parkinson's (PD) very limited. It suggested that its neuroprotective are mediated by ETs-derived metabolites-urolithins. In this study, we examined the capability pomegranate for protection PD in rat model parkinsonism induced rotenone. To...
Melissa officinalis (MO, English: lemon balm, Lamiaceae), one of the oldest and still most popular aromatic medicinal plants, is used in phytomedicine for prevention treatment nervous disturbances. The aim our study was to assess effect subchronic (28-fold) administration a 50% ethanol extract MO leaves (200 mg/kg, p.o.) compared with rosmarinic acid (RA, 10 huperzine A (HU, 0.5 on behavioral cognitive responses scopolamine-induced rats. results were linked acetylcholinesterase (AChE),...
Cancer is a leading cause of death worldwide, and the effectiveness treatment consistently not at satisfactory level. This review thoroughly examines present knowledge perspectives honokiol (HON) in cancer therapeutics. The paper synthesizes critical insights into molecular mechanisms underlying observed anticancer effects, emphasizing both vitro vivo studies. effects HON application, primarily common types cancers, are presented. Because therapeutic potential may be limited by its...
Introduction: Cannabis sativa L. (CSL) extract has pain-relieving potential due to its cannabinoid content, so the effects of two CSL extracts on alleviating neuropathic pain were investigated in vivo. Methods and groups: Male Wistar rats (n = 130) divided into groups received vincristine (0.1 mg/kg) gabapentin (60 induce relieve or (D B). The mRNA protein expression receptors type 1 2 (CB1R, CB2R) evaluated cerebral cortex, hippocampus, lymphocytes. Behavioural tests (Tail-Flick von Frey)...
We present a new programmable neighborhood mechanism for hardware implemented Kohonen self-organizing maps (SOMs) with three different map topologies realized on single chip. The proposed circuit comes as fully parallel and asynchronous architecture. is very fast. In medium sized several hundreds neurons in the complementary metal-oxide semiconductor 0.18 μm technology, all start adapting weights after no more than 11 ns. adaptation then carried out parallel. This an evident advantage...
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Łukasz Mikołajczak P, Kędzia B, Ożarowski M, et al. Evaluation of anti-inflammatory and analgesic activities extracts from herb Chelidonium majus L. Central European Journal Immunology. 2015;40(4):400-410. doi:10.5114/ceji.2015.54607. APA Mikołajczak, P., Kędzia, B., Ożarowski, M., Kujawski, R., Bogacz, A., & Bartkowiak-Wieczorek, J. (2015). Immunology, 40(4), 400-410. https://doi.org/10.5114/ceji.2015.54607...
The aim of the study was to investigate combined effects flavonoids (apigenin, baicalein, chrysin, quercetin, and scutellarin) methyldopa on expression selected proinflammatory vascular factors in vitro for prediction their action pregnancy-induced hypertension. research conducted a trophoblast-derived human choriocarcinoma cell line primary umbilical vein endothelial line. Cytotoxicity compounds concentrations (20, 40, 100 µmol) measured using MTT test concentration 40 µmol further...
Pomegranate juice (PJ) is a rich source of ellagitannins (ETs), precursors colonic metabolite urolithin A, which are believed to contribute pomegranate’s neuroprotective effect. While many experimental studies involving PJ’s role in Alzheimer’s disease and hypoxic-ischemic brain injury have been conducted, our knowledge effects against Parkinson’s (PD) very limited. Previously, we reported that PJ treatment improved postural stability, correlated well with enhancement neuronal survival,...
Inflammation is the critical component of neuropathic pain; therefore, this study aimed to assess potential anti-inflammatory effects Cannabis sativa L. extracts in a vincristine-induced model pain. The different doses (5.0–40.0 mg/kg) two (B and D) on COX-1, COX-2, TNF-α, NF-κB mRNA protein levels were examined rat hippocampus, cerebral cortex, blood lymphocytes. There statistically significant differences TNF-α expression hippocampus with COX-2 Extract D dose-dependently increased COX-1...
There is a hypothesis that ghrelin could take part in the central effects of alcohol as well function peripheral indicator changes which occur during long-term consumption. The aim this study was to determine correlation between concentration and acylated total form after single administration (intraperitoneal, i.p.) (experiment 1) prolonged ethanol consumption 2). performed using Wistar preferring (PR) non-preferring (NP) rats from inbred line (Warsaw High Preferring, WHP; Warsaw Low WLP)....
The conjugate 8 was obtained as a result of condensation 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect OAO-ASA (8) for the range doses 0.3 – 300.0 mg/kg (p.o.) performed mice using hot plate test. Anti-inflammatory activity assessed on carrageenan-induced paw edema rats same doses. did not significantly change locomotor mice, therefore sedative properties compound should be excluded. proved simple, proportional, dose-dependent analgesic action expressed...
Rich in polyphenols, cranberry juice (CJ) with high antioxidant activity is believed to contribute various health benefits. However, our knowledge of the neuroprotective potential cranberries limited. Previously, we have demonstrated that CJ treatment controls oxidative stress several organs, most evident effect brain. In this study, examined capability for protection against Parkinson's disease (PD) a rotenone (ROT) rat model. Wistar rats were administered dose 500 mg/kg b.w./day (i.g.) and...
Eryngium planum L. (EP) is as a rare medicinal plant with lot of potentials pharmaceutical crops. The aim our study was to assess the effect subchronic (28-fold) administration 70% ethanol extract EP roots (200 mg/kg, p.o.) on behavioral and cognitive responses in Wistar rats linked acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), beta-secretase (BACE-1) mRNA levels AChE BuChE activities hippocampus frontal cortex. On last day experiment, 30 min after dose or Huperzine A (HU),...
ABSTRACT The objective of the study was to investigate stability polyphenols and ascorbic acid in osmo-dried fruits: apples, sour cherries blackcurrants, stored for 12 months. After 1 year storage, content total anthocyanins convectively dried blackcurrants decreased by 45% 90%, respectively. Flavonols remained highly stable. Convectively contained particularly labile substances, including cyanidin derivatives, which 98% after 6 Polyphenols freeze-dried materials were more their at 60–80%...
Morphine is co-administered with adjuvant drugs to treat pain, nausea, vomiting, dyspnoea and delirium in cancer patients.To investigate analgesic effects of morphine when drugs.Two-month-old male Wistar rats received single doses alone (0.45 0.9 mg/kg) or midazolam (0.3 mg/kg), haloperidol (0.15 0.45 levomepromazine (0.35 metoclopramide (1.0 hyoscine butylbromide (1.7 as subcutaneous injections. Analgesia was measured by the tail-flick test after 15, 30, 45, 60, 90 min drug administration....
The aim of this study was to assess the activity extracts from Platycodon grandiflorum A. DC (PG) in a model chronic bronchitis rats. research carried out on three water extracts: E1 – roots field cultivated PG; E2 biotransformed E3 callus PG. differed saponins and inulin levels—the highest measured lowest E1. Identification secondary metabolites performed using two complementary LC-MS systems. Chronic induced by sodium metabisulfite (a source SO2). Animals were treated with for weeks (100...
The study aimed to explore in vivo the influence of cannabidiol (CBD) on development alcohol tolerance rats. Rats were treated with ethanol (3.0 g/kg, i.p.) and CBD (20 mg/kg, p.o.) for nine successive days, rectal body temperature, sedation (sleeping time), blood concentration (BAC) measured. In prefrontal cortex, hippocampus, striatum, cannabinoid (CB1R CB2R) dopaminergic (DRD1, DRD2, DRD4, DRD5) receptors’ mRNA level changes analyzed using quantitative RT-PCR method. inhibited hypothermic...
A series of novel compounds were synthesized in reactions N(3) -substituted amidrazones with cis-1,2-cyclohexanedicarboxylic anhydride: linear, isoindole, and triazole derivatives. All new structures confirmed by H(1) NMR IR spectrometry as well elemental analysis. Potential biological effects predicted the Prediction Activity Spectra for Substances (PASS) program. Antiviral, antibacterial, analgesic, anti-inflammatory activities experimentally verified.
Abstract 10-Alkylthiocolchicines have been obtained and characterized by spectroscopic methods their biological activities as: cytotoxic, anti-inflammatory analgesic tested. Cytotoxic activity against SKOV-3 ovarian cell line for 10-alkylthiocolchicine analogues was reported tested compounds showed to be more active than commonly used doxorubicin. Some of C-10 alkylthiolated colchicines found exhibit cytotoxicity at levels comparable that the natural product—colchicine....