A5082401237- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Metal complexes synthesis and properties
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- High Altitude and Hypoxia
- Cancer-related Molecular Pathways
- Hippo pathway signaling and YAP/TAZ
- Cell Adhesion Molecules Research
- RNA Research and Splicing
- Cancer Research and Treatments
- Cellular Mechanics and Interactions
- HER2/EGFR in Cancer Research
- Microtubule and mitosis dynamics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Crystal structures of chemical compounds
- Spectroscopy and Chemometric Analyses
- Neuroblastoma Research and Treatments
- Adsorption and biosorption for pollutant removal
- Histone Deacetylase Inhibitors Research
- Cancer-related gene regulation
- Organometallic Compounds Synthesis and Characterization
- Ectopic Pregnancy Diagnosis and Management
First Affiliated Hospital of Fujian Medical University
2022-2024
Fujian Medical University
2022-2024
Jiangsu University
2023-2024
Suzhou Municipal Hospital
2024
Nanjing Medical University
2024
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2013-2024
Central South University
2022-2024
Third Affiliated Hospital of Sun Yat-sen University
2022-2024
Xiangya Hospital Central South University
2024
MicroRNAs (miRNAs) are involved in a plethora of important biological processes, from embryonic development to homeostasis adult tissues. Recently, miRNAs have emerged as class epigenetic regulators metabolism and energy homeostasis. We investigated the role regulation adipogenic differentiation. In this article, we demonstrate that miR-27 gene family is downregulated during Overexpression specifically inhibited adipocyte formation, without affecting myogenic also found expression resulted...
Background Accumulating evidence shows that dysregulation of intestinal flora is associated with inflammatory skin diseases, specifically atopic dermatitis (AD), psoriasis (PSO), and rosacea (ROS). However, the causality still unclear. Objectives To study underlying between gut microbiota (GM) AD, PSO, ROS, a bi-directional two-sample Mendelian randomization (2SMR) analysis was conducted. Methods Summary statistics microbiota, ROS were extracted from large-scale genome-wide association...
The transcription factor HIF-1α activity is increased in adipose tissue to contribute chronic inflammation obesity. However, its upstream and downstream events remain be characterized We addressed this issue by investigating adipocyte response obesity-associated factors, such as adipogenesis, insulin, hypoxia. In tissue, both mRNA protein were underlying mechanism was investigated 3T3-L1 adipocytes. augmented differentiation. differentiated adipocytes, insulin further enhanced levels....
The stem cell niche is a unique tissue microenvironment that regulates the self-renewal and differentiation of cells. Although several stromal cells molecular pathways have been identified, remains largely unclear. Recent evidence suggests are localized in areas with low oxygen. We hypothesized hypoxia maintains undifferentiated phenotype stem/precursor In this report, we demonstrate reversibly arrests preadipocytes an state. Consistent observation, expression pref-1, key gene negatively...
Cediranib directly suppresses homology-directed DNA repair in tumor cells and confers synthetic lethal vulnerability to PARP inhibitors.
The hypoxia-inducible transcription factors (HIF) 1α and HIF-2α play a critical role in cellular response to hypoxia. Elevated HIF-α expression correlates with poor patient survival large number of cancers. Recent evidence suggests that appears be preferentially expressed neuronal tumor cells exhibit cancer stem cell characteristics. These observations suggest HIF-1α is differentially regulated the hypoxic microenvironment. However, underlying mechanisms remain fully investigated. In this...
Tumor hypoxia is an independent prognostic factor associated with poor patient survival. Emerging evidence suggests that can potentially maintain or enhance the stem cell phenotype of both normal cells and cancer cells. However, it remains to be determined whether fate regulated in vivo by hypoxic tumor microenvironment (TME). We established a hypoxia-sensing xenograft model identify primarily using human breast lines MDA-MB-231 MCF7. Hypoxic were identified situ fluorescence green protein....
Previous studies have indicated that myoblasts can differentiate and repair muscle injury after an ischemic insult. However, it is unclear how hypoxia or glucose deprivation in the microenvironment affects myoblast differentiation. We found myogenesis adapt to hypoxic conditions. This adaptive mechanism accompanied by initial inhibition of myoD, E2A, myogenin genes followed resumption their expression oxygen-dependent manner. The regulation myoD transcription correlated with transient...
Reduced oxygenation, or hypoxia, inhibits differentiation and facilitates stem cell maintenance. Hypoxia commonly occurs in solid tumors promotes malignant progression. Hypoxic are aggressive exhibit cell-like characteristics. It remains unclear, however, whether how hypoxia regulates cancer maintains stemness. Here, we show that increases the expression of gene DLK1, delta-like 1 homologue (Drosophila), neuronal tumor cells. Inhibition DLK1 enhances spontaneous differentiation, decreases...
The regulation of cadherin-mediated adhesion at the cell surface underlies several morphogenetic processes. To investigate role cadherin in morphogenesis and to begin analyze molecular mechanisms regulation, we have screened for monoclonal antibodies (mAbs) that allow us manipulate adhesive state molecule. Xenopus C-cadherin is regulated during convergent extension movements gastrulation. Treatment animal pole tissue explants (animal caps) with mesoderm-inducing factor activin induces...
Our previous study showed that circulating microvesicles (cMVs) of diabetic mice have negative effects on the function endothelial progenitor cells (EPCs). Whether this is true in patients deserves further study. In study, cMVs and EPC-derived MVs (EPC-MVs) EPC migration, apoptosis, reactive oxygen species (ROS) production healthy controls, well-controlled, uncontrolled were investigated. The levels miR-126 vascular growth factor receptor 2 (VEGFR2) cMVs, EPC-MVs, and/or EPCs analyzed....
Abstract Adipocyte dysfunction correlates with the development of diabetes. Here we show that mice a adipocyte-specific deletion SUMO-specific protease SENP1 gene develop symptoms type-1 diabetes mellitus (T1DM), including hyperglycaemia and glucose intolerance mild insulin resistance. Peri-pancreatic adipocytes from SENP1-deficient exhibit heightened NF-κB activity production proinflammatory cytokines, which induce CCL5 expression in adjacent pancreatic islets direct cytotoxic effects on...
Laminar specificity is one of the most striking features neocortical circuitry. To explore molecular basis this specificity, particularly in relation to thalamocortical connectivity, we searched for genes expressed upper cortical layers by constructing a subtraction cDNA library that was enriched layer 4 perinatal rat somatosensory cortex. Differential screening, sequence analysis and situ hybridization demonstrated new unc5 family member (unc5h4), deltex-like gene, stem cell factor (SCF)...
Obesity can cause structural and functional abnormalities of the heart via complex but largely undefined mechanisms. Emerging evidence has shown that obesity results in reduced oxygen concentrations, or hypoxia, adipose tissue. We hypothesized adipocyte hypoxia-signaling pathway plays an essential role development obesity-associated cardiomyopathy.Using a mouse model which hypoxia-inducible factor (HIF) is activated by deletion von Hippel-Lindau gene specifically adipocytes, we found mice...