A5102923315- Trauma and Emergency Care Studies
- Biochemical and Structural Characterization
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Machine Learning in Materials Science
- Sepsis Diagnosis and Treatment
- Probiotics and Fermented Foods
- Nutrition and Health Studies
- Antimicrobial Peptides and Activities
- Emergency and Acute Care Studies
- Metabolism and Genetic Disorders
- Radiomics and Machine Learning in Medical Imaging
- Enzyme Structure and Function
- Microbial Natural Products and Biosynthesis
- Global Health Care Issues
- Amino Acid Enzymes and Metabolism
- Adolescent and Pediatric Healthcare
- Health, Medicine and Society
- Computational Drug Discovery Methods
University of Groningen
2024
AGH University of Krakow
2019
Wrocław University of Science and Technology
2019
King's College Hospital
2016
Sandwell & West Birmingham Hospitals NHS Trust
2011
ASCT2 is an obligate exchanger of neutral amino acids, contributing to cellular acid homeostasis. belongs the same family (SLC1) as Excitatory Amino Acid Transporters (EAATs) that concentrate glutamate in cytosol. The mechanism makes rather than a concentrator remains enigmatic. Here, we employ cryo-electron microscopy and molecular dynamics simulations elucidate structural basis exchange ASCT2. We establish binds three Na+ ions per transported substrate visits state likely acts checkpoint...
Faced with the worldwide spread of multidrug-resistant (MDR) bacterial strains, together a lack any appropriate treatment, urgent steps to combat infectious diseases should be taken. Usually, components are studied understand, by analogy, functioning human proteins. However, molecular data from bacteria gathered over past decades provide sound basis for search novel approaches in medical care. With this current work, we want direct attention inhibition vSGLT glucose transporter Vibrio...
Objectives and Backgrounds In most Emergency Departments (EDs) around the country proformas are in use for management of patients with specific complaints. Proformas improve documentation, handover seen to reduce clinical risk by giving visible guidance physicians. SWBH encompasses two large EDs seeing over 190 000 per year. Head injury, alcohol intoxication headache were introduced November 2009, following an analysis serious untoward incidents (SUIs), decrease these patient safety. This...