A5032158706- Diabetes, Cardiovascular Risks, and Lipoproteins
- Nutritional Studies and Diet
- Lipid metabolism and disorders
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Obesity, Physical Activity, Diet
- Metabolomics and Mass Spectrometry Studies
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Long-Term Effects of COVID-19
- Cardiovascular Health and Risk Factors
- Vitamin C and Antioxidants Research
- Cancer-related molecular mechanisms research
- Lipoproteins and Cardiovascular Health
- Diet, Metabolism, and Disease
- Suicide and Self-Harm Studies
- Tryptophan and brain disorders
- Renal function and acid-base balance
- COVID-19 and Mental Health
- Health Systems, Economic Evaluations, Quality of Life
- Antioxidant Activity and Oxidative Stress
- Health and Well-being Studies
- Clinical Laboratory Practices and Quality Control
- Regulation of Appetite and Obesity
- Health, Environment, Cognitive Aging
Mashhad University of Medical Sciences
2019-2025
Islamic Azad University, Shahrood
2021
Abstract Introduction Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein (LDL-C), triglycerides (TG), or a decreased high-density (HDL-C) concentration. is an established risk factor for cardiovascular disease (CVD). We aimed to investigate the association dyslipidemia and CVD events among population sample from Mashhad, in northeastern Iran. Material methods This prospective cohort study comprised 8698 men women aged 35–65 years who were...
Following up with recovered coronavirus disease 2019 (COVID-19) patients is necessary. Given the importance of psychological function accompanied by significant effects food quality, we want to examine association between quality score (FQS) and mental disorders among COVID-19 patients. This case-control study was performed on 246 eligible adults. A validated frequency questionnaire (FFQ) used evaluate dietary intake. We using Depression Anxiety Stress Scales, Insomnia Severity Index,...
Abstract Background Systemic inflammation is emerging as an important factor in the etiology of psychiatric disorders such depression and anxiety. Therefore, inflammatory potential diet may also be etiological for these conditions, this estimated by calculating dietary index (DII ® ) score. We aimed to investigate association between DII score incidence anxiety among a representative sample northeastern Iran. Methods This cross-sectional study undertook sub-sample 7083 adults aged 35 65...
Abstract In this study, we aimed to investigate the relationship between genetic variant of rs696217‐ghrelin and fasted lipid profile, indices obesity, environmental parameters. Amplification refractory mutation system‐polymerase chain reaction (ARMs‐PCR) was used for genotyping 1118 individuals recruited as part Mashhad Stroke Heart Atherosclerotic Disorder (MASHAD) cohort study. The interaction presence nutritional intake other major determinants obesity profile examined in MASHAD study...
Abstract Age‐ and sex‐specific reference intervals (RIs) for some biochemical tests may be useful their interpretation, due to the variations in lifestyle genetic, or ethnic factors. The aim of this study was obtain RIs routine markers including a serum lipid profile, fasting blood glucose (FBG), aspartate alanine aminotransferase (AST ALT), uric acid, body mass index (BMI) subjects who attended primary healthcare centers. large database centers uses report results children, adolescents,...
Abstract Background Recent investigations have evaluated the effect of inflammatory potential diet in several populations by calculating Dietary Inflammatory Index (DII) score. We aimed to evaluate association DII with Healthy Eating (HEI), Alternative (AHEI), and dietary pattern (DP) among healthy Iranian adults. Methods A cross‐sectional study was conducted 4365 middle‐aged Major DPs score were identified using a validated semi‐quantitative food frequency questionnaire (FFQ). Poisson...
Abstract Background Follow-up of patients after recovery from coronavirus disease 2019 (COVID-19) and identifying the adverse effects in other organs is necessary. Psychiatric symptoms can persist recover infection. Aim We aimed to examine adherence dietary approach stop hypertension (DASH) diet relation psychological function individuals who have recovered COVID-19. Method This case–control study was conducted on 246 eligible adults (123 cases 123 controls). A valid reliable food frequency...
Abstract Background Cardiovascular disease (CVD) is a significant cause of morbidity and mortality globally. Obesity an important CVD risk factor increasing in prevalence. Methods In this study, 3829 men 5720 women (35‐65 years) were enrolled as part the MASHAD cohort study. Four categories identified according to body mass index waist circumference that was defined by World Health Organization. Logistic regression analysis used determine adjusted odds ratio (OR) for occurrence CVD, Cox...
The Angiopoietin-like 3 (ANGPTL3) gene has been reported to be associated with cardiovascular risk. This study is designed compare the genetic variant (rs1748195) of ANGPTL3 and presence a coronary artery occlusion >50% in Iranian nation.
Abstract Background Reference values of biochemical markers are influenced by various parameters including age, sex, region, and lifestyle. Hence, we aimed to determine age‐ BMI‐specific reference intervals (RIs) for important clinical biomarkers in a healthy adult male population from northeastern Iran. This is also the first study investigate pro‐oxidant‐antioxidant balance (PAB). Methods Seven hundred twenty (720) men, aged 20‐60 years, were recruited Sarakhs northeast region lipid...
Background: The association between the presence of dyslipidemia and major dietary patterns was examined in an adult Iranian population. Study design: A cross-sectional study. Methods: This study conducted among 4672 adults aged 35-65 yr old based on data from Mashhad Stroke And Heart Atherosclerotic Disorder (MASHAD) initiated 2010. Anthropometric blood laboratory measurements were collected for all participants. Dietary intake assessed using a validated 65-item food frequency questionnaire...
Reference intervals (RIs) are important tools for improving medical decision-making. Hematology reference values can be influenced by covariates such as genetic and environmental factors, rendering it essential to define RIs specific populations. Therefore, we aimed establish accurate robust hematological markers in a healthy adult male Iranian population. This cross-sectional study was conducted population of 723 males aged 20-60 years old. Hematological parameters were routinely measured...
Metabolic Syndrome (MetS) is defined by a clustering of metabolic abnormalities associated with an increased risk cardiovascular disease and type 2 diabetes mellitus. There has been increasing interest in the associations genetic variant involved obesity FABP1 pathway. The relationship between rs2241883 polymorphism MetS remains unclear.We aimed to examine association this presence its constituent factors.A total 942 participants were recruited as part Mashhad Stroke Heart Atherosclerosis...
The aim of this study was to establish RIs for clinically important markers including superoxide dismutase (SOD), serum copper, zinc, calcium, magnesium, and phosphate in a cohort healthy Iranian adults.A subsample from MASHAD used assess SOD, magnesium phosphate. Serum SOD measured according its inhibitory potential pyrogallol oxidation. Micro- macro-minerals were using flame atomic absorption spectrometry BT3000 autoanalyzer, respectively. Sex- age-specific then calculated based on CLSI...
Background : The association between the presence of dyslipidemia and major dietary patterns was examined in an adult Iranian population. Study design: A cross-sectional study. Methods: This study conducted among 4672 adults aged 35-65 yr old based on data from Mashhad Stroke And Heart Atherosclerotic Disorder (MASHAD) initiated 2010. Anthropometric blood laboratory measurements were collected for all participants. Dietary intake assessed using a validated 65-item food frequency...
Abstract Background and Aims The fatty acid‐binding proteins (FABPs) gene polymorphisms are related to several metabolic properties. We investigated the association of SNPs rs2241883 FABP 1 with obesity evaluate role FABP1 in pathogenesis population MASHAD study cohort. Methods In this cross‐sectional study, 2731 individuals (1883 Obese 848 nonobese) aged 35 65 years old, were enrolled from Mashhad Stroke Heart Atherosclerotic Disorder (MASHAD) DNA Quantitation was determined using...
Abstract Introduction: Cardiovascular disease (CVD) is the leading cause of mortality and one main challenges for health systems worldwide. In this study, we aimed to evaluate role socio-demographic, lifestyle, psychological factors, anthropometric measurements, presence underlying diseases in CVD progression among a subpopulation Iranian adults. Methods A total 235 patients were enrolled. The control group also included healthy non-symptomatic individuals (n = 8405). Health lifestyle...
Suicide has grown in global prevalence as a public health problem. We aimed to evaluate the association of socioeconomic factors, biochemical and hematologic tests, suicide ideation.In this cross-sectional study, 8267 Iranian adults aged 35 - 65 years old were enrolled. The assessment ideation was made by completion Beck's depression inventory (BDI) questionnaire; according one specific item on questionnaire: "have you ever decided past week?"According our results, 6.9 % subjects had...
We aimed to define specific reference intervals (RIs) for 11 biomarkers including inflammatory and oxidative stress biomarkers, liver, renal function tests in a healthy Iranian adult population the first time.CLSI Ep28-A3 guidelines were then used calculate accurate age- sex- as well body mass index (BMI)-specific RIs.RIs studied showed no significant age sex-specific differences, except uric acid, which had higher concentrations men when compared women. Additionally, after partitioning...
Abstract Background Angiopoietin-like 3 (ANGPTL3)-deficiency due to loss-of-function variants are being reported have a link with triglyceride (TG) level, and high-density lipoprotein cholesterol (HDL-C), thereby affecting the risk of cardiovascular disease (CVD). Objective In present study, we examined association rs10789117 in ANGPTL gene locus CVD group people who were part Mashhad-Stroke Heart-Atherosclerotic-Disorders (MASHAD) cohort. Method 1002 cases with/without following 10 years...