A5023356170- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Pluripotent Stem Cells Research
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Amino Acid Enzymes and Metabolism
- Photoreceptor and optogenetics research
- Tryptophan and brain disorders
- Cardiac pacing and defibrillation studies
- Diet and metabolism studies
- CAR-T cell therapy research
- Traditional Chinese Medicine Studies
- Neurogenesis and neuroplasticity mechanisms
- Folate and B Vitamins Research
- Cancer, Hypoxia, and Metabolism
- 3D Printing in Biomedical Research
- Metabolomics and Mass Spectrometry Studies
- Epigenetics and DNA Methylation
University of Milano-Bicocca
2018-2023
Healthy aging is an ambitious aspiration for humans, but neurodegenerative disorders, such as Alzheimer's disease (AD), strongly affect quality of life. Using integrated omics approach, we investigate alterations in the molecular composition postmortem hippocampus samples healthy persons and individuals with AD. Profound differences are apparent between control AD male female cohorts terms up- downregulated metabolic pathways. A decrease insulin response evident when comparing group. The...
NOS1AP single-nucleotide polymorphisms (SNPs) correlate with QT prolongation and cardiac sudden death in patients affected by long syndrome type 1 (LQT1). targets NOS1 to intracellular effectors. We hypothesize that SNPs cause dysfunction this may converge prolonged action-potential duration (APD) facilitate arrhythmias. Here we test (i) the effects of inhibition their interaction APD a guinea pig cardiomyocyte (GP-CMs) LQT1 model; (ii) whether pluripotent stem cell-derived cardiomyocytes...
Phospholamban (PLN) is the natural inhibitor of sarco/endoplasmic reticulum Ca
Liver cancer is one of the most common worldwide with a high mortality. Methionine an essential amino acid required for normal development and cell growth, mainly metabolized in liver, its role as anti-cancer supplement still controversial. Here, we evaluate effects methionine supplementation liver cells. An integrative proteomic metabolomic analysis indicates rewiring central carbon metabolism, upregulation tricarboxylic (TCA) cycle mitochondrial adenosine triphosphate (ATP) production...
Astrocytes are essential players in development and functions, being particularly relevant as regulators of brain energy metabolism, ionic homeostasis synaptic transmission. They also the major source l ‐serine brain, which is synthesized from glycolytic intermediate 3‐phosphoglycerate through phosphorylated pathway. ‐Serine precursor two main co‐agonists N ‐methyl‐ d ‐aspartate receptor, glycine ‐serine. Strikingly, dysfunctions both ‐ metabolism associated with neurological psychiatric...
Increases in action potential duration (APD), genetic or acquired, and arrhythmias are often associated; nonetheless, the relationship between two phenomena is inconstant, suggesting coexisting factors. -adrenergic activation increases sarcoplasmic reticulum (SR) Ca2+-content; angiotensin II (ATII) may increase cytosolic Ca2+ ROS production, all actions stimulating RyRs opening. Here we test how APD interacts with β-adrenergic AT-receptor stimulation facilitating spontaneous release events...
Phospholamban (PLN) is the natural inhibitor of sarco/endoplasmic reticulum Ca2+ ATPase (SERCA2a). Heterozygous PLN-R14del mutation associated with an arrhythmogenic dilated cardiomyopathy (DCM), whose pathogenesis has been attributed to SERCA2a "superinhibition." The aim project test in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) harvested from a carrier whether (1) dynamics and protein localization were compatible superinhibition (2) functional abnormalities could...